| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AKUS | Former 10% Owner | Jun 30, 2020 | Buy | $17.00 | 125,000 | 2,125,000 | 1,181,258 | Jul 02, 2020, 04:16 PM |
| GRTX | Former 10% Owner | Jun 19, 2020 | Sale | $8.25 | 1,001,312 | 8,260,824 | 2,467,961 | Jun 22, 2020, 04:52 PM |
| GRTX | Former 10% Owner | Jun 18, 2020 | Sale | $9.04 | 900 | 8,136 | 3,469,273 | Jun 22, 2020, 04:52 PM |
| GRTX | 10% Owner | Jun 17, 2020 | Sale | $9.27 | 4,622 | 42,846 | 3,470,173 | Jun 17, 2020, 05:47 PM |
| GRTX | 10% Owner | Jun 16, 2020 | Sale | $9.30 | 8,600 | 79,980 | 3,474,795 | Jun 17, 2020, 05:47 PM |
| GRTX | 10% Owner | Jun 15, 2020 | Sale | $9.05 | 6,164 | 55,784 | 3,483,395 | Jun 17, 2020, 05:47 PM |
| GRTX | 10% Owner | Jun 10, 2020 | Sale | $9.46 | 8,532 | 80,713 | 3,498,259 | Jun 12, 2020, 06:33 PM |
| GRTX | 10% Owner | Jun 12, 2020 | Sale | $9.19 | 1,500 | 13,785 | 3,489,559 | Jun 12, 2020, 06:33 PM |
| GRTX | 10% Owner | Jun 11, 2020 | Sale | $9.21 | 7,200 | 66,312 | 3,491,059 | Jun 12, 2020, 06:33 PM |
| GRTX | 10% Owner | Jun 09, 2020 | Sale | $9.38 | 7,000 | 65,660 | 3,506,791 | Jun 09, 2020, 08:02 PM |
| GRTX | 10% Owner | Jun 08, 2020 | Sale | $9.66 | 5,659 | 54,666 | 3,513,791 | Jun 09, 2020, 08:02 PM |
| GRTX | 10% Owner | Jun 05, 2020 | Sale | $9.66 | 8,652 | 83,578 | 3,519,450 | Jun 09, 2020, 08:02 PM |
| GRTX | 10% Owner | Jun 02, 2020 | Sale | $9.68 | 5,669 | 54,876 | 3,537,398 | Jun 04, 2020, 05:36 PM |
| GRTX | 10% Owner | Jun 04, 2020 | Sale | $9.55 | 4,088 | 39,040 | 3,528,102 | Jun 04, 2020, 05:36 PM |
| GRTX | 10% Owner | Jun 03, 2020 | Sale | $9.78 | 5,208 | 50,934 | 3,532,190 | Jun 04, 2020, 05:36 PM |
| GRTX | 10% Owner | Nov 12, 2019 | Buy | $12.00 | 250,000 | 3,000,000 | 3,543,067 | Nov 12, 2019, 04:15 PM |
| BCYC | 10% Owner | May 28, 2019 | Buy | $14.00 | 168,630 | 2,360,820 | 1,769,641 | May 30, 2019, 09:27 PM |
| ARPO | 10% Owner | Apr 26, 2019 | Sale | $1.03 | 138,704 | 142,865 | 4,049,804 | Apr 29, 2019, 05:23 PM |
| ARPO | 10% Owner | Apr 25, 2019 | Sale | $1.03 | 563,096 | 579,989 | 4,188,508 | Apr 29, 2019, 05:23 PM |
| ARPO | 10% Owner | Apr 24, 2019 | Sale | $1.03 | 16,403 | 16,895 | 4,751,604 | Apr 24, 2019, 07:03 PM |
| ARPO | 10% Owner | Apr 23, 2019 | Sale | $1.03 | 27,554 | 28,381 | 4,768,007 | Apr 24, 2019, 07:03 PM |
| ARPO | 10% Owner | Apr 22, 2019 | Sale | $0.97 | 7,100 | 6,887 | 4,795,561 | Apr 24, 2019, 07:03 PM |
| ARPO | 10% Owner | Apr 11, 2019 | Sale | $1.08 | 57,438 | 62,033 | 4,862,363 | Apr 15, 2019, 09:26 PM |
| ARPO | 10% Owner | Apr 15, 2019 | Sale | $0.99 | 28,794 | 28,506 | 4,802,661 | Apr 15, 2019, 09:26 PM |
| ARPO | 10% Owner | Apr 12, 2019 | Sale | $1.04 | 30,908 | 32,144 | 4,831,455 | Apr 15, 2019, 09:26 PM |
| ARPO | 10% Owner | Apr 10, 2019 | Sale | $1.09 | 140,230 | 152,851 | 4,919,801 | Apr 10, 2019, 06:26 PM |
| ARPO | 10% Owner | Apr 09, 2019 | Sale | $1.01 | 32,991 | 33,321 | 5,060,031 | Apr 10, 2019, 06:26 PM |
| ARPO | 10% Owner | Apr 08, 2019 | Sale | $1.02 | 27,525 | 28,075 | 5,093,022 | Apr 10, 2019, 06:26 PM |
| ARPO | 10% Owner | Apr 03, 2019 | Sale | $0.96 | 58,033 | 55,712 | 5,193,108 | Apr 05, 2019, 05:14 PM |
| ARPO | 10% Owner | Apr 05, 2019 | Sale | $1.02 | 24,661 | 25,154 | 5,120,547 | Apr 05, 2019, 05:14 PM |
| ARPO | 10% Owner | Apr 04, 2019 | Sale | $1.01 | 47,900 | 48,379 | 5,145,208 | Apr 05, 2019, 05:14 PM |
| ALRN | 10% Owner | Apr 01, 2019 | Sale | $1.90 | 20,610 | 39,159 | 2,079,394 | Apr 02, 2019, 08:23 PM |
| ALRN | 10% Owner | Mar 29, 2019 | Sale | $1.85 | 106,540 | 197,099 | 2,100,004 | Apr 02, 2019, 08:23 PM |
| ARPO | 10% Owner | Mar 29, 2019 | Sale | $0.91 | 63,100 | 57,421 | 5,419,804 | Apr 02, 2019, 08:09 PM |
| ARPO | 10% Owner | Apr 02, 2019 | Sale | $0.97 | 51,754 | 50,201 | 5,251,141 | Apr 02, 2019, 08:09 PM |
| ARPO | 10% Owner | Apr 01, 2019 | Sale | $0.95 | 116,909 | 111,064 | 5,302,895 | Apr 02, 2019, 08:09 PM |
| ARPO | 10% Owner | Mar 28, 2019 | Sale | $0.94 | 88,835 | 83,505 | 5,482,904 | Mar 28, 2019, 05:16 PM |
| ARPO | 10% Owner | Mar 27, 2019 | Sale | $0.99 | 50,749 | 50,242 | 5,571,739 | Mar 28, 2019, 05:16 PM |
| ARPO | 10% Owner | Mar 26, 2019 | Sale | $1.01 | 177,762 | 179,540 | 5,622,488 | Mar 28, 2019, 05:16 PM |
| ALRN | 10% Owner | Mar 14, 2019 | Sale | $1.88 | 13,800 | 25,944 | 2,250,344 | Mar 15, 2019, 05:25 PM |
| ALRN | 10% Owner | Mar 13, 2019 | Sale | $2.12 | 132,738 | 281,405 | 2,264,144 | Mar 15, 2019, 05:25 PM |
| ALRN | 10% Owner | Mar 15, 2019 | Sale | $1.92 | 43,800 | 84,096 | 2,206,544 | Mar 15, 2019, 05:25 PM |
| ALRN | 10% Owner | Aug 20, 2018 | Sale | $2.30 | 20,388 | 46,892 | 2,396,882 | Aug 22, 2018, 04:34 PM |
| ARPO | 10% Owner | Aug 20, 2018 | Sale | $3.90 | 5,300 | 20,670 | 5,800,250 | Aug 22, 2018, 04:07 PM |
| ALRN | 10% Owner | Aug 17, 2018 | Sale | $2.10 | 8,700 | 18,270 | 2,417,270 | Aug 20, 2018, 05:12 PM |
| ALRN | 10% Owner | Aug 16, 2018 | Sale | $2.10 | 8,808 | 18,497 | 2,425,970 | Aug 20, 2018, 05:12 PM |
| ALRN | 10% Owner | Aug 15, 2018 | Sale | $2.15 | 2,635 | 5,665 | 2,434,778 | Aug 16, 2018, 04:18 PM |
| ALRN | 10% Owner | Aug 14, 2018 | Sale | $2.26 | 3,300 | 7,458 | 2,437,413 | Aug 16, 2018, 04:18 PM |
| ALRN | 10% Owner | Aug 13, 2018 | Sale | $2.36 | 1,600 | 3,776 | 2,440,713 | Aug 14, 2018, 05:05 PM |
| ALRN | 10% Owner | Aug 10, 2018 | Sale | $2.44 | 5,615 | 13,701 | 2,442,313 | Aug 14, 2018, 05:05 PM |
| ALRN | 10% Owner | Aug 08, 2018 | Sale | $2.78 | 1,000 | 2,780 | 2,448,163 | Aug 10, 2018, 04:29 PM |
| ALRN | 10% Owner | Aug 09, 2018 | Sale | $2.48 | 235 | 583 | 2,447,928 | Aug 10, 2018, 04:29 PM |
| ALRN | 10% Owner | Aug 07, 2018 | Sale | $2.97 | 1,739 | 5,165 | 2,449,163 | Aug 08, 2018, 04:21 PM |
| ALRN | 10% Owner | Aug 06, 2018 | Sale | $3.02 | 2,942 | 8,885 | 2,450,902 | Aug 08, 2018, 04:21 PM |
| ALRN | 10% Owner | Aug 02, 2018 | Sale | $3.33 | 4,702 | 15,658 | 2,453,844 | Aug 06, 2018, 04:22 PM |
| ALRN | 10% Owner | Jul 31, 2018 | Sale | $3.07 | 4,500 | 13,815 | 2,466,727 | Aug 02, 2018, 04:33 PM |
| ALRN | 10% Owner | Aug 01, 2018 | Sale | $3.22 | 8,181 | 26,343 | 2,458,546 | Aug 02, 2018, 04:33 PM |
| ALRN | 10% Owner | Jul 30, 2018 | Sale | $3.27 | 2,000 | 6,540 | 2,471,227 | Jul 31, 2018, 04:16 PM |
| ALRN | 10% Owner | Jul 27, 2018 | Sale | $3.38 | 6,458 | 21,828 | 2,473,227 | Jul 31, 2018, 04:16 PM |
| ALRN | 10% Owner | Jul 26, 2018 | Sale | $3.63 | 7,937 | 28,811 | 2,479,685 | Jul 27, 2018, 04:21 PM |
| ALRN | 10% Owner | Jul 25, 2018 | Sale | $3.84 | 12,460 | 47,846 | 2,487,622 | Jul 27, 2018, 04:21 PM |
| ALRN | 10% Owner | Jul 23, 2018 | Sale | $4.25 | 30,600 | 130,050 | 2,500,782 | Jul 25, 2018, 04:35 PM |
| ALRN | 10% Owner | Jul 24, 2018 | Sale | $4.11 | 700 | 2,877 | 2,500,082 | Jul 25, 2018, 04:35 PM |
| ALRN | 10% Owner | Jul 17, 2018 | Sale | $4.71 | 12,500 | 58,875 | 2,531,382 | Jul 18, 2018, 04:17 PM |
| ALRN | 10% Owner | Jul 16, 2018 | Sale | $5.15 | 300 | 1,545 | 2,543,882 | Jul 18, 2018, 04:17 PM |
| AGLE | 10% Owner | May 11, 2018 | Sale | $10.06 | 19,550 | 196,673 | 2,175,314 | May 14, 2018, 04:01 PM |
| AGLE | 10% Owner | May 09, 2018 | Sale | $10.11 | 51,230 | 517,935 | 2,217,589 | May 11, 2018, 04:28 PM |
| AGLE | 10% Owner | May 10, 2018 | Sale | $10.13 | 22,725 | 230,204 | 2,194,864 | May 11, 2018, 04:28 PM |
| AGLE | 10% Owner | May 08, 2018 | Sale | $10.03 | 26,557 | 266,367 | 2,268,819 | May 09, 2018, 04:01 PM |
| AGLE | 10% Owner | May 07, 2018 | Sale | $10.11 | 15,548 | 157,190 | 2,295,376 | May 09, 2018, 04:01 PM |
| ALRN | 10% Owner | Jul 05, 2017 | Buy | $15.00 | 266,667 | 4,000,005 | 2,544,182 | Jul 05, 2017, 06:05 PM |
| RARX | 10% Owner | Jun 16, 2017 | Sale | $21.24 | 53,200 | 1,130,207 | 2,254,677 | Jun 20, 2017, 04:41 PM |
| RARX | 10% Owner | Jun 19, 2017 | Sale | $22.02 | 3,220 | 70,899 | 2,251,457 | Jun 20, 2017, 04:41 PM |
| RARX | 10% Owner | Jun 08, 2017 | Sale | $22.00 | 700 | 15,400 | 2,307,877 | Jun 12, 2017, 04:12 PM |
| RARX | 10% Owner | Jun 07, 2017 | Sale | $22.11 | 4,840 | 106,999 | 2,308,577 | Jun 08, 2017, 04:33 PM |
| RARX | 10% Owner | Jun 06, 2017 | Sale | $22.98 | 7,274 | 167,161 | 2,313,417 | Jun 08, 2017, 04:33 PM |
| RARX | 10% Owner | Jun 05, 2017 | Sale | $23.11 | 4,780 | 110,488 | 2,320,691 | Jun 06, 2017, 04:27 PM |
| RARX | 10% Owner | Jun 02, 2017 | Sale | $23.47 | 14,867 | 348,949 | 2,325,471 | Jun 06, 2017, 04:27 PM |
| RARX | 10% Owner | Jun 01, 2017 | Sale | $23.89 | 10,722 | 256,176 | 2,340,338 | Jun 02, 2017, 04:25 PM |
| RARX | 10% Owner | May 31, 2017 | Sale | $23.94 | 35,539 | 850,896 | 2,351,060 | Jun 02, 2017, 04:25 PM |
| RARX | 10% Owner | May 26, 2017 | Sale | $25.14 | 5,300 | 133,267 | 2,386,599 | May 30, 2017, 04:29 PM |
| RARX | 10% Owner | May 25, 2017 | Sale | $25.00 | 53 | 1,325 | 2,391,899 | May 30, 2017, 04:29 PM |
| RARX | 10% Owner | May 24, 2017 | Sale | $25.01 | 17,451 | 436,364 | 2,391,952 | May 25, 2017, 04:57 PM |
| RARX | 10% Owner | May 18, 2017 | Sale | $25.50 | 9,019 | 229,964 | 2,409,403 | May 22, 2017, 06:50 PM |
| RARX | 10% Owner | May 17, 2017 | Sale | $25.51 | 22,534 | 574,901 | 2,418,422 | May 18, 2017, 04:36 PM |
| RARX | 10% Owner | May 16, 2017 | Sale | $26.33 | 20,081 | 528,725 | 2,440,956 | May 18, 2017, 04:36 PM |
| RARX | 10% Owner | Feb 27, 2017 | Sale | $20.96 | 57,844 | 1,212,306 | 2,476,662 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Feb 24, 2017 | Sale | $20.93 | 5,398 | 113,000 | 2,534,506 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Feb 23, 2017 | Sale | $21.04 | 4,999 | 105,160 | 2,539,904 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Feb 22, 2017 | Sale | $21.86 | 749 | 16,370 | 2,544,903 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Mar 01, 2017 | Sale | $20.91 | 7,778 | 162,658 | 2,461,037 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Feb 28, 2017 | Sale | $20.86 | 7,847 | 163,670 | 2,468,815 | May 02, 2017, 05:22 PM |
| RARX | 10% Owner | Oct 31, 2016 | Buy | $13.00 | 84,615 | 1,099,995 | 2,545,652 | Oct 31, 2016, 04:50 PM |
| RARX | 10% Owner | Oct 31, 2016 | Sale | $13.00 | 339 | 4,407 | 62,575 | Oct 31, 2016, 04:50 PM |
| RARX | 10% Owner | Oct 31, 2016 | Option Exercise | $0.07 | 62,914 | 4,404 | 62,914 | Oct 31, 2016, 04:50 PM |
| AGLE | 10% Owner | Apr 12, 2016 | Buy | $10.00 | 300,000 | 3,000,000 | 2,310,924 | Apr 12, 2016, 05:09 PM |
| PTI | 10% Owner | Feb 17, 2016 | Buy | $8.00 | 375,000 | 3,000,000 | 1,873,791 | Feb 17, 2016, 06:47 PM |
| TKAI | 10% Owner | Jul 15, 2015 | Sale | $14.26 | 3,566 | 50,844 | 4,493,458 | Jul 17, 2015, 04:05 PM |
| TKAI | 10% Owner | Jul 14, 2015 | Sale | $14.41 | 27,861 | 401,477 | 4,497,024 | Jul 15, 2015, 04:18 PM |
| TKAI | 10% Owner | Jul 13, 2015 | Sale | $14.20 | 20,611 | 292,717 | 4,524,885 | Jul 15, 2015, 04:18 PM |
| TKAI | 10% Owner | Jun 16, 2015 | Sale | $14.27 | 1,120 | 15,982 | 4,545,496 | Jun 18, 2015, 12:54 PM |
| TKAI | 10% Owner | Jun 15, 2014 | Sale | $14.20 | 14,777 | 209,833 | 4,546,616 | Jun 16, 2015, 04:17 PM |
| TKAI | 10% Owner | Jun 12, 2015 | Sale | $14.20 | 5,919 | 84,050 | 4,561,393 | Jun 16, 2015, 04:17 PM |
| TKAI | 10% Owner | Jun 11, 2015 | Sale | $14.20 | 27,875 | 395,825 | 4,567,312 | Jun 12, 2015, 04:05 PM |
| TKAI | 10% Owner | Mar 19, 2015 | Sale | $14.50 | 46,141 | 669,045 | 4,595,187 | Mar 20, 2015, 02:37 PM |
| TKAI | 10% Owner | Mar 18, 2015 | Sale | $14.50 | 3,000 | 43,500 | 4,641,328 | Mar 20, 2015, 02:37 PM |
| TKAI | 10% Owner | Sep 22, 2014 | Buy | $15.00 | 325,000 | 4,875,000 | 4,644,328 | Sep 24, 2014, 05:42 PM |
| AKBA | 10% Owner | Mar 25, 2014 | Buy | $17.00 | 182,590 | 3,104,030 | 182,590 | Mar 27, 2014, 04:02 PM |
| CLDN | 10% Owner | Feb 04, 2014 | Option Exercise | $8.00 | 16,537 | 132,296 | 1,389,335 | Feb 06, 2014, 03:52 PM |
| CLDN | 10% Owner | Feb 04, 2014 | Buy | $8.00 | 162,386 | 1,299,088 | 1,551,721 | Feb 06, 2014, 03:52 PM |
| MRNA | 10% Owner | Jan 26, 2011 | Sale | $1.17 | 74,500 | 87,130 | 2,568,565 | Jan 27, 2011, 04:08 PM |
| MRNA | 10% Owner | Jan 25, 2011 | Sale | $1.12 | 93,005 | 104,567 | 2,660,070 | Jan 27, 2011, 04:08 PM |
| MRNA | 10% Owner | Jan 24, 2011 | Sale | $1.20 | 72,800 | 87,222 | 2,735,070 | Jan 25, 2011, 04:30 PM |
| MRNA | 10% Owner | Jan 21, 2011 | Sale | $1.25 | 69,500 | 87,218 | 2,804,670 | Jan 25, 2011, 04:30 PM |
| MRNA | 10% Owner | Jan 20, 2011 | Sale | $1.47 | 5,700 | 8,364 | 2,810,470 | Jan 21, 2011, 04:43 PM |
| MRNA | 10% Owner | Jan 20, 2011 | Sale | $1.35 | 45,700 | 61,697 | 2,855,270 | Jan 21, 2011, 04:42 PM |
| MRNA | 10% Owner | Jan 19, 2011 | Sale | $1.53 | 42,800 | 65,419 | 2,888,170 | Jan 21, 2011, 04:42 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AKUS | Former 10% Owner | Jun 30, 2020 | Buy | 2,125,000 |
| GRTX | Former 10% Owner | Jun 19, 2020 | Sale | 8,260,824 |
| GRTX | Former 10% Owner | Jun 18, 2020 | Sale | 8,136 |
| GRTX | 10% Owner | Jun 17, 2020 | Sale | 42,846 |
| GRTX | 10% Owner | Jun 16, 2020 | Sale | 79,980 |
| GRTX | 10% Owner | Jun 15, 2020 | Sale | 55,784 |
| GRTX | 10% Owner | Jun 10, 2020 | Sale | 80,713 |
| GRTX | 10% Owner | Jun 12, 2020 | Sale | 13,785 |
| GRTX | 10% Owner | Jun 11, 2020 | Sale | 66,312 |
| GRTX | 10% Owner | Jun 09, 2020 | Sale | 65,660 |
| GRTX | 10% Owner | Jun 08, 2020 | Sale | 54,666 |
| GRTX | 10% Owner | Jun 05, 2020 | Sale | 83,578 |
| GRTX | 10% Owner | Jun 02, 2020 | Sale | 54,876 |
| GRTX | 10% Owner | Jun 04, 2020 | Sale | 39,040 |
| GRTX | 10% Owner | Jun 03, 2020 | Sale | 50,934 |
| GRTX | 10% Owner | Nov 12, 2019 | Buy | 3,000,000 |
| BCYC | 10% Owner | May 28, 2019 | Buy | 2,360,820 |
| ARPO | 10% Owner | Apr 26, 2019 | Sale | 142,865 |
| ARPO | 10% Owner | Apr 25, 2019 | Sale | 579,989 |
| ARPO | 10% Owner | Apr 24, 2019 | Sale | 16,895 |
| ARPO | 10% Owner | Apr 23, 2019 | Sale | 28,381 |
| ARPO | 10% Owner | Apr 22, 2019 | Sale | 6,887 |
| ARPO | 10% Owner | Apr 11, 2019 | Sale | 62,033 |
| ARPO | 10% Owner | Apr 15, 2019 | Sale | 28,506 |
| ARPO | 10% Owner | Apr 12, 2019 | Sale | 32,144 |
| ARPO | 10% Owner | Apr 10, 2019 | Sale | 152,851 |
| ARPO | 10% Owner | Apr 09, 2019 | Sale | 33,321 |
| ARPO | 10% Owner | Apr 08, 2019 | Sale | 28,075 |
| ARPO | 10% Owner | Apr 03, 2019 | Sale | 55,712 |
| ARPO | 10% Owner | Apr 05, 2019 | Sale | 25,154 |
| ARPO | 10% Owner | Apr 04, 2019 | Sale | 48,379 |
| ALRN | 10% Owner | Apr 01, 2019 | Sale | 39,159 |
| ALRN | 10% Owner | Mar 29, 2019 | Sale | 197,099 |
| ARPO | 10% Owner | Mar 29, 2019 | Sale | 57,421 |
| ARPO | 10% Owner | Apr 02, 2019 | Sale | 50,201 |
| ARPO | 10% Owner | Apr 01, 2019 | Sale | 111,064 |
| ARPO | 10% Owner | Mar 28, 2019 | Sale | 83,505 |
| ARPO | 10% Owner | Mar 27, 2019 | Sale | 50,242 |
| ARPO | 10% Owner | Mar 26, 2019 | Sale | 179,540 |
| ALRN | 10% Owner | Mar 14, 2019 | Sale | 25,944 |
| ALRN | 10% Owner | Mar 13, 2019 | Sale | 281,405 |
| ALRN | 10% Owner | Mar 15, 2019 | Sale | 84,096 |
| ALRN | 10% Owner | Aug 20, 2018 | Sale | 46,892 |
| ARPO | 10% Owner | Aug 20, 2018 | Sale | 20,670 |
| ALRN | 10% Owner | Aug 17, 2018 | Sale | 18,270 |
| ALRN | 10% Owner | Aug 16, 2018 | Sale | 18,497 |
| ALRN | 10% Owner | Aug 15, 2018 | Sale | 5,665 |
| ALRN | 10% Owner | Aug 14, 2018 | Sale | 7,458 |
| ALRN | 10% Owner | Aug 13, 2018 | Sale | 3,776 |
| ALRN | 10% Owner | Aug 10, 2018 | Sale | 13,701 |
| ALRN | 10% Owner | Aug 08, 2018 | Sale | 2,780 |
| ALRN | 10% Owner | Aug 09, 2018 | Sale | 583 |
| ALRN | 10% Owner | Aug 07, 2018 | Sale | 5,165 |
| ALRN | 10% Owner | Aug 06, 2018 | Sale | 8,885 |
| ALRN | 10% Owner | Aug 02, 2018 | Sale | 15,658 |
| ALRN | 10% Owner | Jul 31, 2018 | Sale | 13,815 |
| ALRN | 10% Owner | Aug 01, 2018 | Sale | 26,343 |
| ALRN | 10% Owner | Jul 30, 2018 | Sale | 6,540 |
| ALRN | 10% Owner | Jul 27, 2018 | Sale | 21,828 |
| ALRN | 10% Owner | Jul 26, 2018 | Sale | 28,811 |
| ALRN | 10% Owner | Jul 25, 2018 | Sale | 47,846 |
| ALRN | 10% Owner | Jul 23, 2018 | Sale | 130,050 |
| ALRN | 10% Owner | Jul 24, 2018 | Sale | 2,877 |
| ALRN | 10% Owner | Jul 17, 2018 | Sale | 58,875 |
| ALRN | 10% Owner | Jul 16, 2018 | Sale | 1,545 |
| AGLE | 10% Owner | May 11, 2018 | Sale | 196,673 |
| AGLE | 10% Owner | May 09, 2018 | Sale | 517,935 |
| AGLE | 10% Owner | May 10, 2018 | Sale | 230,204 |
| AGLE | 10% Owner | May 08, 2018 | Sale | 266,367 |
| AGLE | 10% Owner | May 07, 2018 | Sale | 157,190 |
| ALRN | 10% Owner | Jul 05, 2017 | Buy | 4,000,005 |
| RARX | 10% Owner | Jun 16, 2017 | Sale | 1,130,207 |
| RARX | 10% Owner | Jun 19, 2017 | Sale | 70,899 |
| RARX | 10% Owner | Jun 08, 2017 | Sale | 15,400 |
| RARX | 10% Owner | Jun 07, 2017 | Sale | 106,999 |
| RARX | 10% Owner | Jun 06, 2017 | Sale | 167,161 |
| RARX | 10% Owner | Jun 05, 2017 | Sale | 110,488 |
| RARX | 10% Owner | Jun 02, 2017 | Sale | 348,949 |
| RARX | 10% Owner | Jun 01, 2017 | Sale | 256,176 |
| RARX | 10% Owner | May 31, 2017 | Sale | 850,896 |
| RARX | 10% Owner | May 26, 2017 | Sale | 133,267 |
| RARX | 10% Owner | May 25, 2017 | Sale | 1,325 |
| RARX | 10% Owner | May 24, 2017 | Sale | 436,364 |
| RARX | 10% Owner | May 18, 2017 | Sale | 229,964 |
| RARX | 10% Owner | May 17, 2017 | Sale | 574,901 |
| RARX | 10% Owner | May 16, 2017 | Sale | 528,725 |
| RARX | 10% Owner | Feb 27, 2017 | Sale | 1,212,306 |
| RARX | 10% Owner | Feb 24, 2017 | Sale | 113,000 |
| RARX | 10% Owner | Feb 23, 2017 | Sale | 105,160 |
| RARX | 10% Owner | Feb 22, 2017 | Sale | 16,370 |
| RARX | 10% Owner | Mar 01, 2017 | Sale | 162,658 |
| RARX | 10% Owner | Feb 28, 2017 | Sale | 163,670 |
| RARX | 10% Owner | Oct 31, 2016 | Buy | 1,099,995 |
| RARX | 10% Owner | Oct 31, 2016 | Sale | 4,407 |
| RARX | 10% Owner | Oct 31, 2016 | Option Exercise | 4,404 |
| AGLE | 10% Owner | Apr 12, 2016 | Buy | 3,000,000 |
| PTI | 10% Owner | Feb 17, 2016 | Buy | 3,000,000 |
| TKAI | 10% Owner | Jul 15, 2015 | Sale | 50,844 |
| TKAI | 10% Owner | Jul 14, 2015 | Sale | 401,477 |
| TKAI | 10% Owner | Jul 13, 2015 | Sale | 292,717 |
| TKAI | 10% Owner | Jun 16, 2015 | Sale | 15,982 |
| TKAI | 10% Owner | Jun 15, 2014 | Sale | 209,833 |
| TKAI | 10% Owner | Jun 12, 2015 | Sale | 84,050 |
| TKAI | 10% Owner | Jun 11, 2015 | Sale | 395,825 |
| TKAI | 10% Owner | Mar 19, 2015 | Sale | 669,045 |
| TKAI | 10% Owner | Mar 18, 2015 | Sale | 43,500 |
| TKAI | 10% Owner | Sep 22, 2014 | Buy | 4,875,000 |
| AKBA | 10% Owner | Mar 25, 2014 | Buy | 3,104,030 |
| CLDN | 10% Owner | Feb 04, 2014 | Option Exercise | 132,296 |
| CLDN | 10% Owner | Feb 04, 2014 | Buy | 1,299,088 |
| MRNA | 10% Owner | Jan 26, 2011 | Sale | 87,130 |
| MRNA | 10% Owner | Jan 25, 2011 | Sale | 104,567 |
| MRNA | 10% Owner | Jan 24, 2011 | Sale | 87,222 |
| MRNA | 10% Owner | Jan 21, 2011 | Sale | 87,218 |
| MRNA | 10% Owner | Jan 20, 2011 | Sale | 8,364 |
| MRNA | 10% Owner | Jan 20, 2011 | Sale | 61,697 |
| MRNA | 10% Owner | Jan 19, 2011 | Sale | 65,419 |