| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| IMPL | COB, CEO and President | Aug 18, 2021 | Buy | $13.99 | 20,000 | 279,790 | 20,000 | Aug 19, 2021, 05:23 PM |
| ACRX | Director | Jun 15, 2020 | Buy | $1.29 | 100,000 | 128,900 | 178,750 | Jun 15, 2020, 06:39 PM |
| ACRX | Director | Jun 15, 2020 | Buy | $1.29 | 100,000 | 128,900 | 178,750 | Jun 15, 2020, 06:01 PM |
| AKBA | Director | Nov 20, 2019 | Buy | $3.41 | 50,000 | 170,500 | 63,700 | Nov 21, 2019, 06:31 AM |
| ARLZ | Chief Executive Officer | Mar 15, 2017 | Buy | $2.46 | 500,000 | 1,230,950 | 3,569,230 | Mar 17, 2017, 04:16 PM |
| POZN | Chief Executive Officer | Nov 12, 2015 | Buy | $6.68 | 448,529 | 2,995,815 | 2,944,888 | Nov 12, 2015, 09:38 PM |
| POZN | Chief Executive Officer | Nov 11, 2015 | Buy | $6.45 | 551,471 | 3,556,712 | 2,496,359 | Nov 12, 2015, 09:38 PM |
| AUXL | CEO and President | Jan 29, 2015 | Option Exercise | $36.53 | 120,134 | 4,388,495 | 0 | Jan 30, 2015, 09:33 AM |
| AUXL | CEO and President | Dec 05, 2014 | Option Exercise | $17.40 | 40,000 | 696,000 | 257,778 | Dec 08, 2014, 04:16 PM |
| AUXL | CEO and President | Dec 05, 2014 | Sale | $33.97 | 40,000 | 1,358,704 | 217,778 | Dec 08, 2014, 04:16 PM |
| ACRX | Director | May 28, 2013 | Buy | $8.39 | 50,000 | 419,500 | 75,000 | May 29, 2013, 12:19 PM |
| ACRX | Director | May 24, 2013 | Buy | $7.78 | 25,000 | 194,500 | 25,000 | May 29, 2013, 12:19 PM |
| AMLN | Director | Aug 08, 2012 | Option Exercise | $31.00 | 21,000 | 651,000 | 10,200 | Aug 10, 2012, 06:36 PM |
| AMLN | Director | Aug 15, 2011 | Option Exercise | $10.74 | 15,000 | 161,095 | 18,000 | Aug 17, 2011, 04:32 PM |
| ISPH | President and CEO | May 13, 2011 | Option Exercise | $5.00 | 446,875 | 2,234,375 | 0 | May 16, 2011, 06:24 PM |
| ISPH | President and CEO | May 13, 2011 | Option Exercise | $5.00 | 203,125 | 1,015,625 | 446,875 | May 16, 2011, 06:24 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| IMPL | COB, CEO and President | Aug 18, 2021 | Buy | 279,790 |
| ACRX | Director | Jun 15, 2020 | Buy | 128,900 |
| ACRX | Director | Jun 15, 2020 | Buy | 128,900 |
| AKBA | Director | Nov 20, 2019 | Buy | 170,500 |
| ARLZ | Chief Executive Officer | Mar 15, 2017 | Buy | 1,230,950 |
| POZN | Chief Executive Officer | Nov 12, 2015 | Buy | 2,995,815 |
| POZN | Chief Executive Officer | Nov 11, 2015 | Buy | 3,556,712 |
| AUXL | CEO and President | Jan 29, 2015 | Option Exercise | 4,388,495 |
| AUXL | CEO and President | Dec 05, 2014 | Option Exercise | 696,000 |
| AUXL | CEO and President | Dec 05, 2014 | Sale | 1,358,704 |
| ACRX | Director | May 28, 2013 | Buy | 419,500 |
| ACRX | Director | May 24, 2013 | Buy | 194,500 |
| AMLN | Director | Aug 08, 2012 | Option Exercise | 651,000 |
| AMLN | Director | Aug 15, 2011 | Option Exercise | 161,095 |
| ISPH | President and CEO | May 13, 2011 | Option Exercise | 2,234,375 |
| ISPH | President and CEO | May 13, 2011 | Option Exercise | 1,015,625 |