| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| XENT | EVP & Chief Financial Officer | May 13, 2022 | Option Exercise | $28.25 | 163,596 | 4,621,587 | 106,366 | May 16, 2022, 06:43 PM |
| BMRN | Director | May 02, 2022 | Option Exercise | $37.46 | 8,500 | 318,410 | 107,892 | May 04, 2022, 12:21 PM |
| BMRN | Director | May 02, 2022 | Sale | $82.09 | 3,878 | 318,345 | 104,032 | May 04, 2022, 12:21 PM |
| XENT | EVP & Chief Financial Officer | Feb 02, 2022 | Option Exercise | $27.31 | 2,329 | 63,597 | 163,596 | Feb 04, 2022, 09:06 PM |
| XENT | EVP & Chief Financial Officer | Nov 29, 2021 | Option Exercise | $26.94 | 6,346 | 170,954 | 129,187 | Dec 01, 2021, 06:07 PM |
| BMRN | Director | May 06, 2021 | Option Exercise | $26.49 | 15,000 | 397,350 | 99,340 | May 07, 2021, 07:48 PM |
| BMRN | Director | May 06, 2021 | Sale | $78.38 | 5,068 | 397,245 | 94,272 | May 07, 2021, 07:48 PM |
| XENT | EVP & Chief Financial Officer | Nov 27, 2020 | Option Exercise | $20.00 | 6,349 | 127,003 | 118,122 | Dec 01, 2020, 05:23 PM |
| XENT | EVP & Chief Financial Officer | Mar 17, 2020 | Buy | $7.80 | 5,000 | 38,997 | 124,471 | Mar 17, 2020, 08:37 PM |
| XENT | EVP & Chief Financial Officer | Mar 16, 2020 | Buy | $12.55 | 10,000 | 125,463 | 119,471 | Mar 17, 2020, 06:02 AM |
| BMRN | Director | Sep 13, 2018 | Option Exercise | $21.51 | 15,000 | 322,650 | 84,610 | Sep 17, 2018, 07:22 PM |
| BMRN | Director | Sep 13, 2018 | Sale | $99.24 | 3,000 | 297,722 | 81,810 | Sep 17, 2018, 07:22 PM |
| BMRN | Director | Aug 27, 2018 | Option Exercise | $14.39 | 15,000 | 215,850 | 71,610 | Aug 29, 2018, 03:51 PM |
| BMRN | Director | Aug 27, 2018 | Sale | $100.12 | 2,000 | 200,236 | 69,610 | Aug 29, 2018, 03:51 PM |
| BMRN | Director | May 17, 2018 | Option Exercise | $38.59 | 15,000 | 578,850 | 51,310 | May 18, 2018, 06:33 PM |
| BMRN | Director | May 05, 2017 | Option Exercise | $17.33 | 7,500 | 129,975 | 34,260 | May 09, 2017, 01:24 PM |
| OMI | EVP, Chief Financial Officer | Feb 06, 2017 | Option Exercise | $36.00 | 3,823 | 137,628 | 84,356 | Feb 13, 2017, 12:43 PM |
| OMI | EVP, Chief Financial Officer | Feb 06, 2017 | Option Exercise | $36.00 | 3,823 | 137,628 | 89,297 | Feb 07, 2017, 02:19 PM |
| OMI | EVP, Chief Financial Officer | Jun 01, 2016 | Option Exercise | $37.29 | 4,941 | 184,250 | 88,179 | Jun 02, 2016, 10:57 AM |
| STAA | Director | May 20, 2016 | Sale | $5.31 | 8,849 | 47,028 | 18,300 | May 23, 2016, 10:37 AM |
| STAA | Director | May 19, 2016 | Sale | $5.38 | 16,151 | 86,821 | 27,149 | May 23, 2016, 10:37 AM |
| OMI | EVP, Chief Financial Officer | Mar 01, 2016 | Option Exercise | $39.41 | 3,262 | 128,555 | 93,120 | Mar 02, 2016, 12:14 PM |
| OMI | EVP, Chief Financial Officer | May 07, 2014 | Buy | $32.50 | 2,500 | 81,250 | 40,566 | May 08, 2014, 11:11 AM |
| OMI | EVP, Chief Financial Officer | Feb 28, 2014 | Buy | $34.85 | 2,500 | 87,125 | 38,066 | Mar 03, 2014, 10:18 AM |
| BMRN | Director | Feb 19, 2013 | Option Exercise | $16.92 | 5,000 | 84,600 | 23,650 | Feb 21, 2013, 02:14 PM |
| BMRN | Director | Feb 19, 2013 | Sale | $57.50 | 5,000 | 287,500 | 18,650 | Feb 21, 2013, 02:14 PM |
| BMRN | Director | Jan 22, 2013 | Option Exercise | $16.92 | 5,000 | 84,600 | 23,650 | Feb 11, 2013, 03:42 PM |
| BMRN | Director | Jan 22, 2013 | Sale | $55.00 | 5,000 | 275,000 | 18,650 | Feb 11, 2013, 03:42 PM |
| BMRN | Director | Jan 02, 2013 | Option Exercise | $16.92 | 10,000 | 169,200 | 28,650 | Jan 04, 2013, 02:38 PM |
| BMRN | Director | Jan 02, 2013 | Sale | $51.25 | 10,000 | 512,500 | 23,650 | Jan 04, 2013, 02:38 PM |
| BMRN | Director | Dec 11, 2012 | Option Exercise | $16.92 | 5,000 | 84,600 | 23,650 | Dec 13, 2012, 07:30 PM |
| BMRN | Director | Dec 11, 2012 | Sale | $49.71 | 5,000 | 248,559 | 18,650 | Dec 13, 2012, 07:30 PM |
| BMRN | Director | Nov 29, 2012 | Option Exercise | $16.92 | 5,000 | 84,600 | 23,650 | Dec 03, 2012, 07:32 PM |
| BMRN | Director | Nov 29, 2012 | Sale | $49.17 | 5,000 | 245,842 | 18,650 | Dec 03, 2012, 07:32 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| XENT | EVP & Chief Financial Officer | May 13, 2022 | Option Exercise | 4,621,587 |
| BMRN | Director | May 02, 2022 | Option Exercise | 318,410 |
| BMRN | Director | May 02, 2022 | Sale | 318,345 |
| XENT | EVP & Chief Financial Officer | Feb 02, 2022 | Option Exercise | 63,597 |
| XENT | EVP & Chief Financial Officer | Nov 29, 2021 | Option Exercise | 170,954 |
| BMRN | Director | May 06, 2021 | Option Exercise | 397,350 |
| BMRN | Director | May 06, 2021 | Sale | 397,245 |
| XENT | EVP & Chief Financial Officer | Nov 27, 2020 | Option Exercise | 127,003 |
| XENT | EVP & Chief Financial Officer | Mar 17, 2020 | Buy | 38,997 |
| XENT | EVP & Chief Financial Officer | Mar 16, 2020 | Buy | 125,463 |
| BMRN | Director | Sep 13, 2018 | Option Exercise | 322,650 |
| BMRN | Director | Sep 13, 2018 | Sale | 297,722 |
| BMRN | Director | Aug 27, 2018 | Option Exercise | 215,850 |
| BMRN | Director | Aug 27, 2018 | Sale | 200,236 |
| BMRN | Director | May 17, 2018 | Option Exercise | 578,850 |
| BMRN | Director | May 05, 2017 | Option Exercise | 129,975 |
| OMI | EVP, Chief Financial Officer | Feb 06, 2017 | Option Exercise | 137,628 |
| OMI | EVP, Chief Financial Officer | Feb 06, 2017 | Option Exercise | 137,628 |
| OMI | EVP, Chief Financial Officer | Jun 01, 2016 | Option Exercise | 184,250 |
| STAA | Director | May 20, 2016 | Sale | 47,028 |
| STAA | Director | May 19, 2016 | Sale | 86,821 |
| OMI | EVP, Chief Financial Officer | Mar 01, 2016 | Option Exercise | 128,555 |
| OMI | EVP, Chief Financial Officer | May 07, 2014 | Buy | 81,250 |
| OMI | EVP, Chief Financial Officer | Feb 28, 2014 | Buy | 87,125 |
| BMRN | Director | Feb 19, 2013 | Option Exercise | 84,600 |
| BMRN | Director | Feb 19, 2013 | Sale | 287,500 |
| BMRN | Director | Jan 22, 2013 | Option Exercise | 84,600 |
| BMRN | Director | Jan 22, 2013 | Sale | 275,000 |
| BMRN | Director | Jan 02, 2013 | Option Exercise | 169,200 |
| BMRN | Director | Jan 02, 2013 | Sale | 512,500 |
| BMRN | Director | Dec 11, 2012 | Option Exercise | 84,600 |
| BMRN | Director | Dec 11, 2012 | Sale | 248,559 |
| BMRN | Director | Nov 29, 2012 | Option Exercise | 84,600 |
| BMRN | Director | Nov 29, 2012 | Sale | 245,842 |