| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| BBIO | Director | May 16, 2022 | Option Exercise | $6.74 | 1,541 | 10,386 | 1,206,982 | May 18, 2022, 04:05 PM |
| BBIO | Director | Mar 01, 2021 | Option Exercise | $71.91 | 524 | 37,681 | 1,204,764 | Mar 03, 2021, 04:05 PM |
| BBIO | Chairman of Pharmaceuticals | Oct 16, 2020 | Option Exercise | $17.00 | 10,256 | 174,352 | 1,214,023 | Oct 19, 2020, 09:14 PM |
| BBIO | Chairman of Pharmaceuticals | Oct 16, 2020 | Sale | $41.00 | 10,256 | 420,496 | 1,203,767 | Oct 19, 2020, 09:14 PM |
| BBIO | Chairman of Pharmaceuticals | Sep 30, 2020 | Option Exercise | $17.00 | 10,000 | 170,000 | 1,213,767 | Oct 01, 2020, 04:05 PM |
| BBIO | Chairman of Pharmaceuticals | Sep 30, 2020 | Sale | $38.00 | 10,000 | 380,000 | 1,203,767 | Oct 01, 2020, 04:05 PM |
| BBIO | Chairman of Pharmaceuticals | Sep 29, 2020 | Sale | $37.50 | 18,200 | 682,500 | 1,203,767 | Sep 29, 2020, 07:02 PM |
| BBIO | Chairman of Pharmaceuticals | Sep 25, 2020 | Sale | $36.83 | 81,057 | 2,985,455 | 1,237,363 | Sep 29, 2020, 07:02 PM |
| BBIO | Chairman of Pharmaceuticals | Feb 10, 2020 | Sale | $36.00 | 20,000 | 720,000 | 1,342,291 | Feb 12, 2020, 07:03 PM |
| BBIO | Chairman of Pharmaceuticals | Jan 14, 2020 | Option Exercise | $17.00 | 10,000 | 170,000 | 1,372,291 | Jan 16, 2020, 07:17 PM |
| BBIO | Chairman of Pharmaceuticals | Jan 14, 2020 | Sale | $35.00 | 10,000 | 350,000 | 1,362,291 | Jan 16, 2020, 07:17 PM |
| PTLA | Director | Jan 02, 2019 | Option Exercise | $5.10 | 45,923 | 234,207 | 165,403 | Jan 04, 2019, 05:46 PM |
| PTLA | Director | Dec 19, 2018 | Option Exercise | $4.10 | 25,782 | 105,706 | 119,480 | Dec 19, 2018, 07:07 PM |
| PTLA | Director | Dec 17, 2018 | Option Exercise | $4.10 | 64,218 | 263,294 | 176,689 | Dec 19, 2018, 07:07 PM |
| PTLA | Director | Dec 17, 2018 | Sale | $18.61 | 64,218 | 1,195,002 | 113,171 | Dec 19, 2018, 07:07 PM |
| PTLA | Director | Nov 14, 2018 | Option Exercise | $4.10 | 93,698 | 384,162 | 93,698 | Nov 16, 2018, 05:24 PM |
| GBT | Director | Oct 26, 2017 | Sale | $33.93 | 54,400 | 1,845,781 | 83,328 | Oct 27, 2017, 05:15 PM |
| GBT | Director | Oct 27, 2017 | Sale | $34.09 | 15,600 | 531,770 | 67,728 | Oct 27, 2017, 05:15 PM |
| PTLA | Director | Jun 23, 2017 | Option Exercise | $5.00 | 120,803 | 604,015 | 120,803 | Jun 27, 2017, 04:51 PM |
| PTLA | Director | Jun 23, 2017 | Sale | $53.06 | 120,803 | 6,409,807 | 0 | Jun 27, 2017, 04:51 PM |
| GBT | Director | Jun 02, 2017 | Sale | $27.20 | 81,701 | 2,222,124 | 169,470 | Jun 22, 2017, 09:38 PM |
| GBT | Director | Jun 01, 2017 | Sale | $26.58 | 18,299 | 486,345 | 219,429 | Jun 22, 2017, 09:38 PM |
| PTLA | Director | Mar 15, 2017 | Option Exercise | $5.00 | 50,000 | 250,000 | 50,000 | Mar 16, 2017, 06:18 PM |
| PTLA | Director | Mar 15, 2017 | Sale | $40.06 | 50,000 | 2,003,000 | 0 | Mar 16, 2017, 06:18 PM |
| PTLA | Director | Mar 01, 2017 | Option Exercise | $5.00 | 25,000 | 125,000 | 25,000 | Mar 03, 2017, 05:02 PM |
| PTLA | Director | Mar 01, 2017 | Sale | $37.50 | 25,000 | 937,500 | 0 | Mar 03, 2017, 05:02 PM |
| PTLA | Director | Sep 18, 2015 | Option Exercise | $4.15 | 40,067 | 166,221 | 20,067 | Sep 18, 2015, 05:15 PM |
| PTLA | Director | Sep 18, 2015 | Sale | $56.25 | 40,067 | 2,253,685 | 0 | Sep 18, 2015, 05:15 PM |
| PTLA | Director | Jul 13, 2015 | Option Exercise | $3.30 | 50,000 | 165,000 | 50,000 | Jul 14, 2015, 06:59 PM |
| PTLA | Director | Jul 13, 2015 | Sale | $48.00 | 50,000 | 2,400,000 | 0 | Jul 14, 2015, 06:59 PM |
| PTLA | Director | Jun 29, 2015 | Option Exercise | $3.30 | 100,000 | 330,000 | 100,000 | Jun 29, 2015, 05:53 PM |
| PTLA | Director | Jun 29, 2015 | Sale | $43.78 | 100,000 | 4,378,448 | 28,076 | Jun 29, 2015, 05:53 PM |
| PTLA | Director | Feb 23, 2015 | Option Exercise | $3.30 | 20,000 | 66,000 | 20,000 | Feb 23, 2015, 04:59 PM |
| PTLA | Director | Feb 23, 2015 | Sale | $40.00 | 20,000 | 800,000 | 0 | Feb 23, 2015, 04:59 PM |
| PTLA | Director | Feb 17, 2015 | Option Exercise | $3.30 | 20,000 | 66,000 | 20,000 | Feb 17, 2015, 04:51 PM |
| PTLA | Director | Feb 17, 2015 | Sale | $36.00 | 20,000 | 720,000 | 0 | Feb 17, 2015, 04:51 PM |
| PTLA | Director | Feb 13, 2015 | Option Exercise | $3.30 | 20,000 | 66,000 | 20,000 | Feb 13, 2015, 05:34 PM |
| PTLA | Director | Feb 13, 2015 | Sale | $34.05 | 20,000 | 680,974 | 0 | Feb 13, 2015, 05:34 PM |
| PTLA | Director | Jan 28, 2015 | Option Exercise | $3.30 | 19,700 | 65,010 | 19,700 | Jan 28, 2015, 05:55 PM |
| PTLA | Director | Jan 28, 2015 | Sale | $30.00 | 19,700 | 591,000 | 0 | Jan 28, 2015, 05:55 PM |
| PTLA | Director | Jan 27, 2015 | Option Exercise | $3.30 | 300 | 990 | 300 | Jan 27, 2015, 08:26 PM |
| PTLA | Director | Jan 27, 2015 | Sale | $30.00 | 300 | 9,000 | 0 | Jan 27, 2015, 08:26 PM |
| PTLA | Director | Oct 22, 2013 | Sale | $23.75 | 95,962 | 2,279,098 | 123,471 | Oct 23, 2013, 08:27 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| BBIO | Director | May 16, 2022 | Option Exercise | 10,386 |
| BBIO | Director | Mar 01, 2021 | Option Exercise | 37,681 |
| BBIO | Chairman of Pharmaceuticals | Oct 16, 2020 | Option Exercise | 174,352 |
| BBIO | Chairman of Pharmaceuticals | Oct 16, 2020 | Sale | 420,496 |
| BBIO | Chairman of Pharmaceuticals | Sep 30, 2020 | Option Exercise | 170,000 |
| BBIO | Chairman of Pharmaceuticals | Sep 30, 2020 | Sale | 380,000 |
| BBIO | Chairman of Pharmaceuticals | Sep 29, 2020 | Sale | 682,500 |
| BBIO | Chairman of Pharmaceuticals | Sep 25, 2020 | Sale | 2,985,455 |
| BBIO | Chairman of Pharmaceuticals | Feb 10, 2020 | Sale | 720,000 |
| BBIO | Chairman of Pharmaceuticals | Jan 14, 2020 | Option Exercise | 170,000 |
| BBIO | Chairman of Pharmaceuticals | Jan 14, 2020 | Sale | 350,000 |
| PTLA | Director | Jan 02, 2019 | Option Exercise | 234,207 |
| PTLA | Director | Dec 19, 2018 | Option Exercise | 105,706 |
| PTLA | Director | Dec 17, 2018 | Option Exercise | 263,294 |
| PTLA | Director | Dec 17, 2018 | Sale | 1,195,002 |
| PTLA | Director | Nov 14, 2018 | Option Exercise | 384,162 |
| GBT | Director | Oct 26, 2017 | Sale | 1,845,781 |
| GBT | Director | Oct 27, 2017 | Sale | 531,770 |
| PTLA | Director | Jun 23, 2017 | Option Exercise | 604,015 |
| PTLA | Director | Jun 23, 2017 | Sale | 6,409,807 |
| GBT | Director | Jun 02, 2017 | Sale | 2,222,124 |
| GBT | Director | Jun 01, 2017 | Sale | 486,345 |
| PTLA | Director | Mar 15, 2017 | Option Exercise | 250,000 |
| PTLA | Director | Mar 15, 2017 | Sale | 2,003,000 |
| PTLA | Director | Mar 01, 2017 | Option Exercise | 125,000 |
| PTLA | Director | Mar 01, 2017 | Sale | 937,500 |
| PTLA | Director | Sep 18, 2015 | Option Exercise | 166,221 |
| PTLA | Director | Sep 18, 2015 | Sale | 2,253,685 |
| PTLA | Director | Jul 13, 2015 | Option Exercise | 165,000 |
| PTLA | Director | Jul 13, 2015 | Sale | 2,400,000 |
| PTLA | Director | Jun 29, 2015 | Option Exercise | 330,000 |
| PTLA | Director | Jun 29, 2015 | Sale | 4,378,448 |
| PTLA | Director | Feb 23, 2015 | Option Exercise | 66,000 |
| PTLA | Director | Feb 23, 2015 | Sale | 800,000 |
| PTLA | Director | Feb 17, 2015 | Option Exercise | 66,000 |
| PTLA | Director | Feb 17, 2015 | Sale | 720,000 |
| PTLA | Director | Feb 13, 2015 | Option Exercise | 66,000 |
| PTLA | Director | Feb 13, 2015 | Sale | 680,974 |
| PTLA | Director | Jan 28, 2015 | Option Exercise | 65,010 |
| PTLA | Director | Jan 28, 2015 | Sale | 591,000 |
| PTLA | Director | Jan 27, 2015 | Option Exercise | 990 |
| PTLA | Director | Jan 27, 2015 | Sale | 9,000 |
| PTLA | Director | Oct 22, 2013 | Sale | 2,279,098 |