| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| EIGR | Chief Financial Officer | Jun 20, 2016 | Buy | $19.80 | 2,000 | 39,592 | 2,000 | Jun 22, 2016, 02:55 PM |
| EIGR | Chief Financial Officer | Jun 22, 2016 | Buy | $19.79 | 500 | 9,897 | 2,500 | Jun 22, 2016, 02:55 PM |
| ACRX | Chief Financial Officer | Sep 07, 2011 | Buy | $3.39 | 3,000 | 10,179 | 15,000 | Sep 07, 2011, 07:53 PM |
| ACRX | Chief Financial Officer | Sep 06, 2011 | Buy | $3.32 | 7,000 | 23,238 | 12,000 | Sep 07, 2011, 07:53 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| EIGR | Chief Financial Officer | Jun 20, 2016 | Buy | 39,592 |
| EIGR | Chief Financial Officer | Jun 22, 2016 | Buy | 9,897 |
| ACRX | Chief Financial Officer | Sep 07, 2011 | Buy | 10,179 |
| ACRX | Chief Financial Officer | Sep 06, 2011 | Buy | 23,238 |