| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| BCRX | Director | Nov 24, 2021 | Buy | $12.19 | 7,500 | 91,425 | 17,500 | Nov 24, 2021, 06:35 PM |
| IDRA | President & CEO | Jan 12, 2021 | Sale | $4.20 | 3,210 | 13,474 | 208,611 | Jan 12, 2021, 07:00 PM |
| IDRA | President & CEO | Jan 05, 2021 | Sale | $3.91 | 2,740 | 10,700 | 211,821 | Jan 11, 2021, 08:09 PM |
| IDRA | President & CEO | Dec 22, 2020 | Sale | $4.32 | 37,169 | 160,525 | 214,561 | Dec 22, 2020, 06:45 PM |
| IDRA | President & CEO | Jan 07, 2020 | Sale | $1.78 | 3,006 | 5,352 | 86,560 | Jan 14, 2020, 06:05 PM |
| IDRA | President & CEO | Jan 07, 2020 | Sale | $1.78 | 3,006 | 5,352 | 86,560 | Jan 10, 2020, 08:14 AM |
| ONCE | Director | Dec 17, 2019 | Option Exercise | $114.50 | 3,000 | 343,500 | 0 | Dec 17, 2019, 04:49 PM |
| IDRA | President & CEO | Dec 24, 2018 | Buy | $2.93 | 15,000 | 43,923 | 55,816 | Dec 26, 2018, 09:21 AM |
| IDRA | President & CEO | Aug 07, 2018 | Buy | $5.51 | 10,000 | 55,100 | 40,816 | Aug 08, 2018, 07:35 PM |
| IDRA | President & CEO | Mar 15, 2016 | Buy | $1.97 | 40,000 | 78,800 | 246,527 | Mar 17, 2016, 08:23 PM |
| IDRA | President and CEO | Dec 12, 2014 | Buy | $4.00 | 200,000 | 799,100 | 200,000 | Dec 15, 2014, 05:01 PM |
| VPHM | President and CEO | Jan 24, 2014 | Option Exercise | $50.00 | 482,281 | 24,114,050 | 0 | Jan 28, 2014, 08:29 PM |
| VPHM | President and CEO | Jan 17, 2014 | Option Exercise | $8.67 | 79,126 | 686,213 | 482,281 | Jan 21, 2014, 11:41 AM |
| VPHM | President and CEO | Jan 06, 2014 | Option Exercise | $3.55 | 40,309 | 143,097 | 403,155 | Jan 07, 2014, 04:08 PM |
| VPHM | President and CEO | Dec 18, 2013 | Option Exercise | $49.74 | 337,810 | 16,802,670 | 362,846 | Dec 20, 2013, 04:08 PM |
| VPHM | President and CEO | Dec 18, 2013 | Option Exercise | $10.78 | 586,310 | 6,317,885 | 416,541 | Dec 20, 2013, 04:08 PM |
| VPHM | President and CEO | Nov 28, 2012 | Option Exercise | $3.55 | 18,000 | 63,900 | 112,416 | Nov 30, 2012, 04:17 PM |
| VPHM | President and CEO | Nov 08, 2012 | Option Exercise | $4.53 | 83,418 | 378,273 | 136,416 | Nov 13, 2012, 04:06 PM |
| VPHM | President and CEO | Nov 08, 2012 | Sale | $24.54 | 83,418 | 2,047,328 | 94,416 | Nov 13, 2012, 04:06 PM |
| VPHM | President and CEO | Jan 04, 2012 | Option Exercise | $27.91 | 7,224 | 201,622 | 94,384 | Jan 06, 2012, 04:10 PM |
| VPHM | President and CEO | Jan 04, 2012 | Option Exercise | $27.91 | 10,000 | 279,100 | 101,608 | Jan 06, 2012, 04:10 PM |
| VPHM | President and CEO | Dec 05, 2011 | Option Exercise | $2.09 | 15,005 | 31,367 | 91,213 | Dec 06, 2011, 04:13 PM |
| VPHM | President and CEO | Nov 21, 2011 | Option Exercise | $3.36 | 76,687 | 257,937 | 117,899 | Nov 23, 2011, 04:03 PM |
| VPHM | President and CEO | Nov 21, 2011 | Sale | $22.53 | 76,687 | 1,727,444 | 76,208 | Nov 23, 2011, 04:03 PM |
| VPHM | President and CEO | Dec 13, 2010 | Option Exercise | $16.89 | 6,272 | 105,934 | 64,390 | Dec 15, 2010, 04:56 PM |
| VPHM | President and CEO | Dec 13, 2010 | Option Exercise | $14.13 | 10,000 | 141,250 | 74,390 | Dec 15, 2010, 04:56 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| BCRX | Director | Nov 24, 2021 | Buy | 91,425 |
| IDRA | President & CEO | Jan 12, 2021 | Sale | 13,474 |
| IDRA | President & CEO | Jan 05, 2021 | Sale | 10,700 |
| IDRA | President & CEO | Dec 22, 2020 | Sale | 160,525 |
| IDRA | President & CEO | Jan 07, 2020 | Sale | 5,352 |
| IDRA | President & CEO | Jan 07, 2020 | Sale | 5,352 |
| ONCE | Director | Dec 17, 2019 | Option Exercise | 343,500 |
| IDRA | President & CEO | Dec 24, 2018 | Buy | 43,923 |
| IDRA | President & CEO | Aug 07, 2018 | Buy | 55,100 |
| IDRA | President & CEO | Mar 15, 2016 | Buy | 78,800 |
| IDRA | President and CEO | Dec 12, 2014 | Buy | 799,100 |
| VPHM | President and CEO | Jan 24, 2014 | Option Exercise | 24,114,050 |
| VPHM | President and CEO | Jan 17, 2014 | Option Exercise | 686,213 |
| VPHM | President and CEO | Jan 06, 2014 | Option Exercise | 143,097 |
| VPHM | President and CEO | Dec 18, 2013 | Option Exercise | 16,802,670 |
| VPHM | President and CEO | Dec 18, 2013 | Option Exercise | 6,317,885 |
| VPHM | President and CEO | Nov 28, 2012 | Option Exercise | 63,900 |
| VPHM | President and CEO | Nov 08, 2012 | Option Exercise | 378,273 |
| VPHM | President and CEO | Nov 08, 2012 | Sale | 2,047,328 |
| VPHM | President and CEO | Jan 04, 2012 | Option Exercise | 201,622 |
| VPHM | President and CEO | Jan 04, 2012 | Option Exercise | 279,100 |
| VPHM | President and CEO | Dec 05, 2011 | Option Exercise | 31,367 |
| VPHM | President and CEO | Nov 21, 2011 | Option Exercise | 257,937 |
| VPHM | President and CEO | Nov 21, 2011 | Sale | 1,727,444 |
| VPHM | President and CEO | Dec 13, 2010 | Option Exercise | 105,934 |
| VPHM | President and CEO | Dec 13, 2010 | Option Exercise | 141,250 |