| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| AVXS | SrVP/Chief Reg&Quality Officer | Apr 02, 2018 | Option Exercise | $18.17 | 5,000 | 90,850 | 8,800 | Apr 04, 2018, 04:56 PM |
| AVXS | SrVP/Chief Reg&Quality Officer | Apr 02, 2018 | Sale | $119.44 | 5,000 | 597,213 | 7,630 | Apr 04, 2018, 04:56 PM |
| AVXS | SrVP/Chief Reg&Quality Officer | Jan 16, 2018 | Option Exercise | $18.17 | 5,000 | 90,850 | 5,000 | Jan 18, 2018, 04:01 PM |
| AVXS | SrVP/Chief Reg&Quality Officer | Jan 16, 2018 | Sale | $106.52 | 5,000 | 532,619 | 4,504 | Jan 18, 2018, 04:01 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| AVXS | SrVP/Chief Reg&Quality Officer | Apr 02, 2018 | Option Exercise | 90,850 |
| AVXS | SrVP/Chief Reg&Quality Officer | Apr 02, 2018 | Sale | 597,213 |
| AVXS | SrVP/Chief Reg&Quality Officer | Jan 16, 2018 | Option Exercise | 90,850 |
| AVXS | SrVP/Chief Reg&Quality Officer | Jan 16, 2018 | Sale | 532,619 |