| Symbol | Relationship | Date | Transaction | Cost | # Shares | Value($) | Total Shares | Form 4 |
| VORB | FORMER DIRECTOR | Dec 29, 2021 | Option Exercise | $10.00 | 125,000 | 1,250,000 | 125,000 | Jan 03, 2022, 07:41 PM |
| ALRN | Director | Jun 08, 2020 | Buy | $1.10 | 227,272 | 249,999 | 445,460 | Jun 09, 2020, 08:23 PM |
| ALRN | Director | Sep 13, 2019 | Buy | $0.97 | 25,000 | 24,255 | 218,188 | Sep 16, 2019, 04:55 PM |
| ALRN | Director | Sep 12, 2019 | Buy | $0.98 | 88,145 | 86,250 | 193,188 | Sep 16, 2019, 04:55 PM |
| ALRN | Director | Sep 04, 2019 | Buy | $0.71 | 23,225 | 16,583 | 105,043 | Sep 05, 2019, 04:09 PM |
| ALRN | Director | Sep 03, 2019 | Buy | $0.70 | 13,466 | 9,428 | 81,818 | Sep 04, 2019, 04:14 PM |
| ALRN | Director | Aug 30, 2019 | Buy | $0.73 | 15,000 | 10,968 | 68,352 | Sep 04, 2019, 04:14 PM |
| ALRN | Director | Aug 29, 2019 | Buy | $0.77 | 3,600 | 2,771 | 53,352 | Sep 03, 2019, 05:17 PM |
| PRXL | Chairman & CEO | Sep 14, 2017 | Option Exercise | $87.93 | 4,642 | 408,171 | 503,329 | Sep 18, 2017, 12:07 PM |
| PRXL | Chairman & CEO | Sep 11, 2017 | Option Exercise | $87.77 | 15,402 | 1,351,833 | 507,971 | Sep 12, 2017, 01:15 PM |
| PRXL | Chairman & CEO | Sep 12, 2016 | Option Exercise | $66.54 | 14,743 | 980,999 | 506,753 | Sep 14, 2016, 09:35 AM |
| PRXL | Chairman & CEO | Sep 21, 2015 | Option Exercise | $72.10 | 26,884 | 1,938,336 | 521,130 | Sep 23, 2015, 12:09 PM |
| PRXL | Chairman & CEO | Feb 13, 2015 | Option Exercise | $63.09 | 117,098 | 7,387,713 | 607,283 | Feb 17, 2015, 11:58 AM |
| PRXL | Chairman & CEO | Feb 13, 2015 | Option Exercise | $26.35 | 172,575 | 4,547,621 | 724,381 | Feb 17, 2015, 11:58 AM |
| PRXL | Chairman & CEO | Feb 13, 2015 | Sale | $62.53 | 65,100 | 4,070,641 | 546,283 | Feb 17, 2015, 11:58 AM |
| PRXL | Chairman & CEO | Sep 22, 2014 | Option Exercise | $61.38 | 35,587 | 2,184,330 | 551,566 | Sep 23, 2014, 12:52 PM |
| PRXL | Chairman & CEO | Feb 10, 2014 | Sale | $49.76 | 50,000 | 2,488,000 | 562,641 | Feb 12, 2014, 07:54 AM |
| PRXL | Chairman & CEO | Feb 07, 2014 | Sale | $49.70 | 50,000 | 2,485,000 | 612,641 | Feb 10, 2014, 02:16 PM |
| PRXL | Chairman & CEO | Feb 06, 2014 | Option Exercise | $49.78 | 55,868 | 2,781,109 | 662,641 | Feb 07, 2014, 02:28 PM |
| PRXL | Chairman & CEO | Feb 06, 2014 | Option Exercise | $26.69 | 77,850 | 2,077,548 | 718,509 | Feb 07, 2014, 02:28 PM |
| PRXL | Chairman & CEO | Sep 23, 2013 | Option Exercise | $49.71 | 124,524 | 6,190,088 | 640,388 | Sep 24, 2013, 09:51 AM |
| PRXL | Chairman & CEO | Sep 23, 2013 | Option Exercise | $19.28 | 184,000 | 3,546,809 | 764,912 | Sep 24, 2013, 09:51 AM |
| PRXL | Chairman & CEO | Sep 16, 2013 | Option Exercise | $49.13 | 29,028 | 1,426,146 | 580,912 | Sep 17, 2013, 04:06 PM |
| PRXL | Chairman & CEO | Jun 04, 2013 | Option Exercise | $46.11 | 68,572 | 3,161,855 | 0 | Jun 06, 2013, 03:28 PM |
| PRXL | Chairman & CEO | May 07, 2013 | Sale | $44.39 | 72,000 | 3,196,080 | 573,651 | May 08, 2013, 01:44 PM |
| PRXL | Chairman & CEO | May 06, 2013 | Sale | $43.88 | 28,000 | 1,228,640 | 645,651 | May 08, 2013, 01:44 PM |
| PRXL | Chairman & CEO | Nov 26, 2012 | Sale | $31.64 | 110,489 | 3,495,872 | 673,325 | Nov 28, 2012, 11:36 AM |
| PRXL | Chairman & CEO | Nov 21, 2012 | Option Exercise | $32.09 | 23,576 | 756,554 | 783,814 | Nov 26, 2012, 02:25 PM |
| PRXL | Chairman & CEO | Nov 21, 2012 | Option Exercise | $12.55 | 36,550 | 458,703 | 807,390 | Nov 26, 2012, 02:25 PM |
| PRXL | Chairman & CEO | Nov 02, 2012 | Option Exercise | $30.44 | 32,869 | 1,000,532 | 770,840 | Nov 06, 2012, 07:43 AM |
| PRXL | Chairman & CEO | Nov 02, 2012 | Option Exercise | $12.55 | 50,000 | 627,500 | 803,709 | Nov 06, 2012, 07:43 AM |
| PRXL | Chairman & CEO | Sep 10, 2012 | Option Exercise | $29.96 | 36,154 | 1,083,174 | 696,609 | Sep 12, 2012, 02:21 PM |
| PRXL | Chairman & CEO | Aug 28, 2012 | Option Exercise | $27.48 | 33,000 | 906,840 | 732,763 | Aug 29, 2012, 12:40 PM |
| PRXL | Chairman & CEO | Aug 28, 2012 | Option Exercise | $11.45 | 50,000 | 572,700 | 765,763 | Aug 29, 2012, 12:40 PM |
| PRXL | Chairman & CEO | Jun 07, 2012 | Option Exercise | $26.83 | 22,670 | 608,236 | 715,763 | Jun 11, 2012, 02:33 PM |
| PRXL | Chairman & CEO | Jun 07, 2012 | Option Exercise | $9.81 | 40,000 | 392,400 | 738,433 | Jun 11, 2012, 02:33 PM |
| PRXL | Chairman & CEO | Feb 17, 2012 | Option Exercise | $25.32 | 11,644 | 294,826 | 697,622 | Feb 21, 2012, 01:53 PM |
| PRXL | Chairman & CEO | Feb 17, 2012 | Option Exercise | $9.81 | 20,000 | 196,200 | 709,266 | Feb 21, 2012, 01:53 PM |
| PRXL | Chairman & CEO | Dec 23, 2011 | Option Exercise | $20.88 | 52,435 | 1,094,843 | 689,266 | Dec 28, 2011, 11:24 AM |
| PRXL | Chairman & CEO | Dec 23, 2011 | Option Exercise | $8.60 | 80,000 | 688,000 | 741,701 | Dec 28, 2011, 11:24 AM |
| PRXL | Chairman & CEO | Sep 11, 2011 | Option Exercise | $20.50 | 14,764 | 302,662 | 585,775 | Sep 13, 2011, 01:42 PM |
| Symbol | Relationship | Date | Transaction | Value($) |
| VORB | FORMER DIRECTOR | Dec 29, 2021 | Option Exercise | 1,250,000 |
| ALRN | Director | Jun 08, 2020 | Buy | 249,999 |
| ALRN | Director | Sep 13, 2019 | Buy | 24,255 |
| ALRN | Director | Sep 12, 2019 | Buy | 86,250 |
| ALRN | Director | Sep 04, 2019 | Buy | 16,583 |
| ALRN | Director | Sep 03, 2019 | Buy | 9,428 |
| ALRN | Director | Aug 30, 2019 | Buy | 10,968 |
| ALRN | Director | Aug 29, 2019 | Buy | 2,771 |
| PRXL | Chairman & CEO | Sep 14, 2017 | Option Exercise | 408,171 |
| PRXL | Chairman & CEO | Sep 11, 2017 | Option Exercise | 1,351,833 |
| PRXL | Chairman & CEO | Sep 12, 2016 | Option Exercise | 980,999 |
| PRXL | Chairman & CEO | Sep 21, 2015 | Option Exercise | 1,938,336 |
| PRXL | Chairman & CEO | Feb 13, 2015 | Option Exercise | 7,387,713 |
| PRXL | Chairman & CEO | Feb 13, 2015 | Option Exercise | 4,547,621 |
| PRXL | Chairman & CEO | Feb 13, 2015 | Sale | 4,070,641 |
| PRXL | Chairman & CEO | Sep 22, 2014 | Option Exercise | 2,184,330 |
| PRXL | Chairman & CEO | Feb 10, 2014 | Sale | 2,488,000 |
| PRXL | Chairman & CEO | Feb 07, 2014 | Sale | 2,485,000 |
| PRXL | Chairman & CEO | Feb 06, 2014 | Option Exercise | 2,781,109 |
| PRXL | Chairman & CEO | Feb 06, 2014 | Option Exercise | 2,077,548 |
| PRXL | Chairman & CEO | Sep 23, 2013 | Option Exercise | 6,190,088 |
| PRXL | Chairman & CEO | Sep 23, 2013 | Option Exercise | 3,546,809 |
| PRXL | Chairman & CEO | Sep 16, 2013 | Option Exercise | 1,426,146 |
| PRXL | Chairman & CEO | Jun 04, 2013 | Option Exercise | 3,161,855 |
| PRXL | Chairman & CEO | May 07, 2013 | Sale | 3,196,080 |
| PRXL | Chairman & CEO | May 06, 2013 | Sale | 1,228,640 |
| PRXL | Chairman & CEO | Nov 26, 2012 | Sale | 3,495,872 |
| PRXL | Chairman & CEO | Nov 21, 2012 | Option Exercise | 756,554 |
| PRXL | Chairman & CEO | Nov 21, 2012 | Option Exercise | 458,703 |
| PRXL | Chairman & CEO | Nov 02, 2012 | Option Exercise | 1,000,532 |
| PRXL | Chairman & CEO | Nov 02, 2012 | Option Exercise | 627,500 |
| PRXL | Chairman & CEO | Sep 10, 2012 | Option Exercise | 1,083,174 |
| PRXL | Chairman & CEO | Aug 28, 2012 | Option Exercise | 906,840 |
| PRXL | Chairman & CEO | Aug 28, 2012 | Option Exercise | 572,700 |
| PRXL | Chairman & CEO | Jun 07, 2012 | Option Exercise | 608,236 |
| PRXL | Chairman & CEO | Jun 07, 2012 | Option Exercise | 392,400 |
| PRXL | Chairman & CEO | Feb 17, 2012 | Option Exercise | 294,826 |
| PRXL | Chairman & CEO | Feb 17, 2012 | Option Exercise | 196,200 |
| PRXL | Chairman & CEO | Dec 23, 2011 | Option Exercise | 1,094,843 |
| PRXL | Chairman & CEO | Dec 23, 2011 | Option Exercise | 688,000 |
| PRXL | Chairman & CEO | Sep 11, 2011 | Option Exercise | 302,662 |