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BAKER BROS. ADVISORS LP

AUM: $21.98 B
13-F Portfolio Value: $7.83 B
Last 13-F Filed: Q2 2024
Concentration in top 10: 76.25%
Filter by:
Stock Company % Portfolio Shares Held Market Value Change in Shares % Change Quarter End Price Source
INCYIncyte Corporation23.40%30,738,524$1,863,369,325-5,441,141-15.04%$60.6213F
BGNEBeiGene, Ltd.18.94%10,568,897$1,507,864,535No Change$142.6713F
ACADACADIA Pharmaceuticals Inc.8.75%42,877,916$696,766,13513,3040.03%$16.2513F
MDGLMadrigal Pharmaceuticals, Inc.6.95%1,974,590$553,201,1344,7920.24%$280.1613F
RVMDRevolution Medicines, Inc.3.69%7,569,090$293,756,38319,8410.26%$38.8113F
KYMRKymera Therapeutics, Inc.3.66%6,001,262$291,361,2705,3340.09%13D
RYTMRhythm Pharmaceuticals, Inc.3.30%6,398,365$262,716,867No Change$41.0613F
INSMInsmed Incorporated3.01%3,576,038$239,594,5463,233,038942.58%$6713F
BCYCBicycle Therapeutics plc2.39%9,399,960$190,255,1904,457,13790.17%$20.2413F
SMMTSummit Therapeutics Inc.2.28%23,222,222$181,133,33223,222,222New$7.813F
EWTXEdgewise Therapeutics, Inc.1.32%5,840,059$105,179,463No Change$18.0113F
ALKSAlkermes plc1.27%4,181,751$100,780,1994,181,751New$24.113F
INSMInsmed Incorporated (PRN)1.14%42,850,000$90,413,50042,850,000New$2.1113F
REPLReplimune Group, Inc.1.14%10,045,336$90,408,024500,0005.24%$913F
DNLIDenali Therapeutics Inc.1.09%3,731,695$86,649,958No Change$23.2213F
ABCLAbCellera Biologics Inc.1.02%27,525,640$81,475,894No Change$2.9613F
NRIXNurix Therapeutics, Inc.1.02%3,882,125$81,019,949No Change$20.8713F
KNSAKiniksa Pharmaceuticals International, plc0.98%3,151,029$77,137,190332,70611.81%13D
IMTXImmatics N.V.0.94%6,443,398$74,872,285No Change$11.6213F
TRDAEntrada Therapeutics, Inc.0.87%4,865,819$69,337,921No Change$14.2513F
RAREUltragenyx Pharmaceutical Inc.0.76%1,466,547$60,275,082No Change$41.113F
STOKStoke Therapeutics, Inc.0.74%4,368,443$59,017,6651,000,00029.69%$13.5113F
INSMInsmed Incorporated (PRN)0.71%32,887,000$56,192,30732,887,000New$1.7113F
IMCRImmunocore Holdings plc0.64%1,515,318$51,354,127No Change$33.8913F
ARGXargenx SE0.60%111,904$48,123,196-39,311-26%$430.0413F
KODKodiak Sciences Inc.0.51%17,310,490$40,679,652No Change$2.3513F
XENEXenon Pharmaceuticals Inc.0.49%993,679$38,743,544No Change$38.9913F
PRLDPrelude Therapeutics Inc.0.48%10,123,824$38,571,769No Change$3.8113F
IDYAIDEAYA Biosciences, Inc.0.47%1,062,123$37,291,139No Change$35.1113F
CERSCerus Corporation0.43%19,477,339$34,280,117No Change$1.7613F
SERASera Prognostics, Inc.0.40%5,434,399$32,171,642No Change$5.9213F
CELCCelcuity Inc.0.39%1,874,978$30,712,140322,50020.77%$16.3813F
KRYSKrystal Biotech, Inc.0.39%169,934$31,206,680No Change$183.6413F
ROIVRoivant Sciences Ltd.0.37%2,798,716$29,582,428-4,615,118-62.25%$10.5713F
CERECerevel Therapeutics Holdings, Inc.0.35%683,588$27,951,913-916,412-57.28%$40.8913F
IGMSIGM Biosciences, Inc.0.35%4,090,316$28,100,4711,9940.05%$6.8713F
AKROAkero Therapeutics, Inc.0.32%1,097,082$25,737,544-1,616,123-59.57%$23.4613F
DYNDyne Therapeutics, Inc.0.30%672,096$23,718,268387,096135.82%$35.2913F
ALMSAlumis Inc.0.26%1,562,500$20,781,2501,562,500New$13.313F
GLUEMonte Rosa Therapeutics, Inc.0.23%4,916,095$18,386,195No Change$3.7413F
MRUSMerus N.V.0.22%300,000$17,751,000300,000New$59.1713F
NGNENeurogene Inc.0.21%456,015$16,594,386No Change$36.3913F
TCRXTScan Therapeutics, Inc.0.20%2,784,792$16,291,033No Change$5.8513F
SANASana Biotechnology, Inc.0.16%2,380,949$12,999,982No Change$5.4613F
IMVTImmunovant, Inc.0.15%464,718$12,268,55539,7099.34%$26.413F
NMRANeumora Therapeutics, Inc.0.13%1,034,600$10,170,118400,74963.22%$9.8313F
XNCRXencor, Inc.0.13%545,431$10,325,009No Change$18.9313F
BMEABiomea Fusion, Inc.0.12%2,108,949$9,490,271No Change$4.513F
CLDXCelldex Therapeutics, Inc.0.12%247,644$9,165,304No Change$37.0113F
FATEFate Therapeutics, Inc.0.12%2,997,772$9,832,6921,179,59164.88%$3.2813F
TSVT2seventy bio, Inc.0.12%2,497,526$9,615,475No Change$3.8513F
TSHATaysha Gene Therapies, Inc.0.11%4,004,756$8,970,653No Change$2.2413F
ATHAAthira Pharma, Inc.0.10%3,153,807$8,357,589No Change$2.6513F
RLAYRelay Therapeutics, Inc.0.10%1,160,117$7,563,963No Change$6.5213F
VERVVerve Therapeutics, Inc.0.10%1,691,530$8,254,666No Change$4.8813F
KALAKALA BIO, Inc.0.08%891,335$6,319,565624,722234.32%$7.0913F
MIRMMirum Pharmaceuticals, Inc.0.08%190,476$6,512,374No Change$34.1913F
TNGXTango Therapeutics, Inc.0.08%750,000$6,435,000No Change$8.5813F
CTNMContineum Therapeutics, Inc.0.07%312,500$5,503,125312,500New$17.6113F
DBVTDBV Technologies S.A.0.07%7,307,131$5,853,0127,307,131New$0.813F
DSGNDesign Therapeutics, Inc.0.07%1,695,294$5,679,23533,1742%$3.3513F
PRAXPraxis Precision Medicines, Inc.0.07%131,533$5,440,205No Change$41.3613F
PRMEPrime Medicine, Inc.0.07%1,028,466$5,286,315No Change$5.1413F
CRSPCRISPR Therapeutics AG0.07%100,000$5,401,000100,000New$54.0113F
CNTACentessa Pharmaceuticals plc0.06%549,212$4,959,384549,212New$9.0313F
CRNXCrinetics Pharmaceuticals, Inc.0.06%103,927$4,654,890103,927New$44.7913F
HOOKHOOKIPA Pharma Inc.0.06%8,128,151$4,810,2408,128,151New$0.5913F
SGMTSagimet Biosciences Inc.0.06%1,381,898$4,726,091No Change$3.4213F
TLISTalis Biomedical Corp0.06%2,506,716$4,311,5521,998,393393.13%13D
ALECAlector, Inc.0.05%927,264$4,209,779927,264New$4.5413F
ARCTArcturus Therapeutics Holdings Inc.0.05%151,329$3,684,861151,329New$24.3513F
OPTOpthea Limited0.05%2,173,622$4,195,090-4,204-0.19%$1.9313F
SKYESkye Bioscience, Inc.0.05%500,000$4,005,000500,000New$8.0113F
PCVXVaxcyte, Inc.0.05%48,885$3,691,306No Change$75.5113F
GBIOGeneration Bio Co.0.04%1,206,957$3,403,619835,738225.13%$2.8213F
ADAPAdaptimmune Therapeutics plc0.03%2,343,695$2,284,868-8,443,327-78.27%$0.9713F
IPSCCentury Therapeutics, Inc.0.03%797,460$2,033,523No Change$2.5513F
ELVNEnliven Therapeutics, Inc.0.03%114,833$2,683,647No Change$23.3713F
LPTXLeap Therapeutics, Inc.0.03%1,172,175$2,297,463No Change$1.9613F
MRSNMersana Therapeutics, Inc.0.03%1,086,115$2,183,091No Change$2.0113F
CMPXCompass Therapeutics, Inc.0.02%1,557,630$1,557,630No Change$113F
SAGESage Therapeutics, Inc.0.02%171,026$1,857,342-236,191-58%$10.8613F
VTVTvTv Therapeutics, Inc.0.02%97,314$1,718,565No Change$17.6613F
NAMSNewAmsterdam Pharma Company N.V.0.02%96,827$1,860,047No Change$19.2113F
ACHLAchilles Therapeutics plc0.01%1,108,767$903,645-100,008-8.27%$0.8113F
AVTEAerovate Therapeutics, Inc.0.01%628,939$1,044,039-1,051,578-62.57%$1.6613F
PFEPfizer Inc.0.01%35,000$979,300No Change$27.9813F
TARAProtara Therapeutics, Inc.0.01%536,832$1,116,611337,161168.86%$2.0813F
ALGSAligos Therapeutics, Inc.0.00913%2,076,400$726,740No Change$0.3513F
PMVPPMV Pharmaceuticals, Inc.0.00655%322,024$521,679No Change$1.6213F
BCRXBioCryst Pharmaceuticals, Inc.0.00588%75,778$468,308-10,050,398-99.25%$6.1813F
ACRVAcrivon Therapeutics, Inc.0.00385%52,885$306,733No Change$5.813F
FHTXFoghorn Therapeutics Inc.0.00325%45,027$258,905No Change$5.7513F
TYRATyra Biosciences, Inc.0.00213%10,607$169,606No Change$15.9913F
SRZNWSurrozen, Inc.0.00017%833,333$13,833No Change$0.0213F
ALPNAlpine Immune Sciences, Inc.-81,578Exited13F
CABACabaletta Bio, Inc.-13,331Exited13F
DBVTDBV Technologies S.A.-14,614,264Exited13F
FDMT4D Molecular Therapeutics, Inc.-100,000Exited13F
HOOKHOOKIPA Pharma Inc.-8,128,151Exited13F
CATXPerspective Therapeutics, Inc.-149,787Exited13F
KNSAKiniksa Pharmaceuticals, Ltd.-2,809,577Exited13F
MURAMural Oncology plc-222,503Exited13F