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| Stock | Company | % Portfolio | Shares Held | Market Value | Change in Shares | % Change | Quarter End Price | Source |
|---|---|---|---|---|---|---|---|---|
| SGEN | Seagen Inc. | 49.82% | 44,554,162 | $8,574,894,019 | -2,359,607 | -5.03% | $192.46 | 13F |
| INCY | Incyte Corporation | 13.08% | 36,178,056 | $2,252,083,986 | 2,656 | 0.00734% | $62.25 | 13F |
| BGNE | BeiGene, Ltd. | 12.09% | 11,668,897 | $2,080,564,335 | No Change | $178.3 | 13F | |
| ACAD | ACADIA Pharmaceuticals Inc. | 5.96% | 42,864,612 | $1,026,607,457 | 926,126 | 2.21% | $23.95 | 13F |
| BMRN | BioMarin Pharmaceutical Inc. | 1.92% | 3,810,248 | $330,272,297 | No Change | $86.68 | 13F | |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | 1.61% | 1,545,113 | $277,332,332 | No Change | 13D | ||
| IMCR | Immunocore Holdings plc | 0.88% | 2,520,731 | $151,143,031 | No Change | $59.96 | 13F | |
| NVTA | Invitae Corporation (PRN) | 0.78% | 300,000,000 | $135,000,000 | 300,000,000 | New | $0.45 | 13F |
| KOD | Kodiak Sciences Inc. | 0.69% | 17,310,490 | $119,442,381 | No Change | $6.9 | 13F | |
| AKRO | Akero Therapeutics, Inc. | 0.64% | 2,368,378 | $110,579,569 | No Change | $46.69 | 13F | |
| ARGX | argenx SE | 0.63% | 280,159 | $109,186,367 | No Change | $389.73 | 13F | |
| ABCL | AbCellera Biologics Inc. | 0.62% | 16,450,180 | $106,268,163 | 6,000,000 | 57.42% | $6.46 | 13F |
| REPL | Replimune Group, Inc. | 0.62% | 4,578,280 | $106,307,662 | No Change | $23.22 | 13F | |
| RYTM | Rhythm Pharmaceuticals, Inc. | 0.62% | 6,498,267 | $107,156,423 | No Change | $16.49 | 13F | |
| KYMR | Kymera Therapeutics, Inc. | 0.58% | 4,375,340 | $100,589,067 | 1,495,515 | 51.93% | $22.99 | 13F |
| ROIV | Roivant Sciences Ltd. | 0.55% | 9,428,592 | $95,040,207 | 4,651,162 | 97.36% | $10.08 | 13F |
| BCRX | BioCryst Pharmaceuticals, Inc. | 0.52% | 12,710,818 | $89,484,159 | No Change | $7.04 | 13F | |
| SWTX | SpringWorks Therapeutics, Inc. | 0.46% | 2,999,846 | $78,655,962 | 246,344 | 8.95% | $26.22 | 13F |
| TRDA | Entrada Therapeutics, Inc. | 0.43% | 4,865,819 | $73,668,500 | No Change | $15.14 | 13F | |
| RVMD | Revolution Medicines, Inc. | 0.42% | 2,691,493 | $71,997,438 | No Change | $26.75 | 13F | |
| IMTX | Immatics N.V. | 0.38% | 5,640,816 | $65,095,017 | 453,735 | 8.75% | $11.54 | 13F |
| KDNY | Chinook Therapeutics, Inc. | 0.32% | 1,455,202 | $55,908,861 | No Change | $38.42 | 13F | |
| MRTX | Mirati Therapeutics, Inc. | 0.30% | 1,409,784 | $50,935,496 | No Change | $36.13 | 13F | |
| DICE | DICE Therapeutics, Inc. | 0.28% | 1,035,786 | $48,122,618 | No Change | $46.46 | 13F | |
| BMEA | Biomea Fusion, Inc. | 0.27% | 2,108,949 | $46,291,431 | No Change | $21.95 | 13F | |
| PRLD | Prelude Therapeutics Inc. | 0.26% | 10,123,824 | $45,557,208 | No Change | $4.5 | 13F | |
| DNLI | Denali Therapeutics Inc. | 0.25% | 1,455,322 | $42,946,552 | 366,584 | 33.67% | $29.51 | 13F |
| CERS | Cerus Corporation | 0.23% | 16,067,558 | $39,526,193 | No Change | $2.46 | 13F | |
| NRIX | Nurix Therapeutics, Inc. | 0.23% | 3,882,125 | $38,782,429 | No Change | $9.99 | 13F | |
| KNSA | Kiniksa Pharmaceuticals, Ltd. | 0.23% | 2,809,577 | $39,558,844 | 10,000 | 0.36% | $14.08 | 13F |
| RARE | Ultragenyx Pharmaceutical Inc. | 0.21% | 783,059 | $36,122,512 | 312,085 | 66.26% | $46.13 | 13F |
| AVTE | Aerovate Therapeutics, Inc. | 0.20% | 1,963,479 | $33,673,665 | No Change | $17.15 | 13F | |
| IGMS | IGM Biosciences, Inc. | 0.17% | 3,157,210 | $29,141,048 | 554 | 0.02% | $9.23 | 13F |
| IMGN | ImmunoGen, Inc. | 0.17% | 1,520,097 | $28,684,230 | 1,520,097 | New | $18.87 | 13F |
| XENE | Xenon Pharmaceuticals Inc. | 0.17% | 751,639 | $28,938,102 | No Change | $38.5 | 13F | |
| DBVT | DBV Technologies S.A. | 0.16% | 14,614,264 | $27,767,102 | No Change | $1.9 | 13F | |
| IDYA | IDEAYA Biosciences, Inc. | 0.15% | 1,062,123 | $24,959,891 | 229,354 | 27.54% | $23.5 | 13F |
| TSVT | 2seventy bio, Inc. | 0.15% | 2,497,526 | $25,274,963 | No Change | $10.12 | 13F | |
| VERV | Verve Therapeutics, Inc. | 0.15% | 1,416,530 | $26,559,938 | No Change | $18.75 | 13F | |
| BCYC | Bicycle Therapeutics plc | 0.13% | 843,814 | $21,534,133 | No Change | $25.52 | 13F | |
| STOK | Stoke Therapeutics, Inc. | 0.13% | 2,130,238 | $22,644,430 | 14,822 | 0.7% | $10.63 | 13F |
| CABA | Cabaletta Bio, Inc. | 0.12% | 1,594,000 | $20,578,540 | 250,000 | 18.6% | $12.91 | 13F |
| KRYS | Krystal Biotech, Inc. | 0.12% | 169,934 | $19,950,252 | -132,782 | -43.86% | $117.4 | 13F |
| GLUE | Monte Rosa Therapeutics, Inc. | 0.12% | 3,023,951 | $20,714,064 | 2,648,856 | 706.18% | $6.85 | 13F |
| MREO | Mereo Biopharma Group plc | 0.11% | 14,604,391 | $19,423,840 | 11,049,412 | 310.82% | 13G | |
| ANAB | AnaptysBio, Inc. | 0.09% | 775,924 | $15,782,294 | No Change | $20.34 | 13F | |
| PACB | Pacific Biosciences of California, Inc. | 0.09% | 1,127,782 | $14,999,501 | No Change | $13.3 | 13F | |
| PRME | Prime Medicine, Inc. | 0.09% | 1,028,466 | $15,067,027 | No Change | $14.65 | 13F | |
| SMMT | Summit Therapeutics Inc. | 0.09% | 6,304,705 | $15,824,810 | No Change | $2.51 | 13F | |
| RLAY | Relay Therapeutics, Inc. | 0.08% | 1,160,117 | $14,571,070 | 876,117 | 308.49% | $12.56 | 13F |
| SPRY | ARS Pharmaceuticals, Inc. | 0.08% | 2,006,451 | $13,443,222 | No Change | $6.7 | 13F | |
| COGT | Cogent Biosciences, Inc. | 0.07% | 979,600 | $11,598,464 | 979,600 | New | $11.84 | 13F |
| DAWN | Day One Biopharmaceuticals, Inc. | 0.07% | 1,000,000 | $11,940,000 | 1,000,000 | New | $11.94 | 13F |
| SANA | Sana Biotechnology, Inc. | 0.07% | 2,000,000 | $11,920,000 | No Change | $5.96 | 13F | |
| ADAP | Adaptimmune Therapeutics plc | 0.06% | 10,969,282 | $10,146,586 | 1,138,405 | 11.58% | $0.93 | 13F |
| GERN | Geron Corporation | 0.06% | 3,061,224 | $9,826,529 | No Change | $3.21 | 13F | |
| NVTA | Invitae Corporation | 0.06% | 8,881,104 | $10,035,648 | No Change | $1.13 | 13F | |
| PNT | POINT Biopharma Global Inc. | 0.06% | 1,169,103 | $10,592,073 | No Change | $9.06 | 13F | |
| ALLO | Allogene Therapeutics, Inc. | 0.05% | 1,576,901 | $7,837,198 | No Change | $4.97 | 13F | |
| ATHA | Athira Pharma, Inc. | 0.05% | 3,153,807 | $9,303,731 | 803,452 | 34.18% | $2.95 | 13F |
| RNA | Avidity Biosciences, Inc. | 0.05% | 799,451 | $8,865,912 | -204,600 | -20.38% | $11.09 | 13F |
| BLUE | bluebird bio, Inc. | 0.05% | 2,499,715 | $8,224,062 | No Change | $3.29 | 13F | |
| FATE | Fate Therapeutics, Inc. | 0.05% | 1,671,717 | $7,957,373 | No Change | $4.76 | 13F | |
| HRTX | Heron Therapeutics, Inc. | 0.05% | 8,131,678 | $9,432,746 | No Change | $1.16 | 13F | |
| NLTX | Neoleukin Therapeutics, Inc. | 0.05% | 12,152,509 | $8,385,231 | 8,330,769 | 217.98% | Form 4 | |
| AADI | Aadi Bioscience, Inc. | 0.04% | 989,928 | $6,771,108 | No Change | $6.84 | 13F | |
| INSM | Insmed Incorporated | 0.04% | 343,000 | $7,237,300 | No Change | $21.1 | 13F | |
| OPT | Opthea Limited | 0.04% | 2,691,391 | $7,535,895 | No Change | $2.8 | 13F | |
| TCRX | TScan Therapeutics, Inc. | 0.04% | 2,784,792 | $6,961,980 | No Change | $2.5 | 13F | |
| ALEC | Alector, Inc. | 0.03% | 964,851 | $5,798,755 | No Change | $6.01 | 13F | |
| CMPX | Compass Therapeutics, Inc. | 0.03% | 1,557,630 | $4,953,263 | No Change | $3.18 | 13F | |
| MGNX | MacroGenics, Inc. | 0.03% | 892,579 | $4,775,298 | No Change | $5.35 | 13F | |
| NTRA | Natera, Inc. | 0.03% | 100,000 | $4,866,000 | No Change | $48.66 | 13F | |
| SERA | Sera Prognostics, Inc. | 0.03% | 1,777,435 | $5,856,648 | -11,565 | -0.65% | $3.29 | 13F |
| ARAV | Aravive, Inc. | 0.02% | 3,261,224 | $4,109,142 | No Change | $1.26 | 13F | |
| BCEL | Atreca, Inc. | 0.02% | 3,532,760 | $3,462,105 | No Change | $0.98 | 13F | |
| IPSC | Century Therapeutics, Inc. | 0.02% | 1,149,340 | $3,631,914 | No Change | $3.16 | 13F | |
| DSGN | Design Therapeutics, Inc. | 0.02% | 500,000 | $3,150,000 | -126,884 | -20.24% | $6.3 | 13F |
| EWTX | Edgewise Therapeutics, Inc. | 0.02% | 500,000 | $3,875,000 | No Change | $7.75 | 13F | |
| GRCL | Gracell Biotechnologies Inc. | 0.02% | 1,000,000 | $3,810,000 | 1,000,000 | New | $3.81 | 13F |
| HOOK | HOOKIPA Pharma Inc. | 0.02% | 4,425,535 | $3,894,471 | 950,000 | 27.33% | $0.88 | 13F |
| TIL | Instil Bio, Inc. | 0.02% | 5,273,789 | $2,905,858 | No Change | $0.55 | 13F | |
| LPTX | Leap Therapeutics, Inc. | 0.02% | 1,172,175 | $3,668,908 | 1,172,175 | New | $3.13 | 13F |
| MRSN | Mersana Therapeutics, Inc. | 0.02% | 1,086,115 | $3,573,318 | -800,000 | -42.42% | $3.29 | 13F |
| TLIS | Talis Biomedical Corporation | 0.02% | 7,624,835 | $3,659,921 | 7,624,835 | New | $0.48 | 13F |
| XNCR | Xencor, Inc. | 0.02% | 123,127 | $3,074,481 | No Change | $24.97 | 13F | |
| AFMD | Affimed N.V. | 0.02% | 6,596,830 | $3,946,224 | No Change | $0.6 | 13F | |
| ACHL | Achilles Therapeutics plc | 0.01% | 2,557,149 | $2,417,017 | -34,217 | -1.32% | $0.95 | 13F |
| ALGS | Aligos Therapeutics, Inc. | 0.01% | 2,076,400 | $2,016,184 | No Change | $0.97 | 13F | |
| ITOS | iTeos Therapeutics, Inc. | 0.01% | 150,346 | $1,990,581 | No Change | $13.24 | 13F | |
| PMVP | PMV Pharmaceuticals, Inc. | 0.01% | 322,024 | $2,015,870 | No Change | $6.26 | 13F | |
| PRAX | Praxis Precision Medicines, Inc. | 0.01% | 1,879,915 | $2,161,902 | No Change | $1.15 | 13F | |
| TNGX | Tango Therapeutics, Inc. | 0.01% | 750,000 | $2,490,000 | No Change | $3.32 | 13F | |
| PCVX | Vaxcyte, Inc. | 0.01% | 48,885 | $2,441,317 | No Change | $49.94 | 13F | |
| VERA | Vera Therapeutics, Inc. | 0.01% | 146,464 | $2,350,747 | -186,869 | -56.06% | $16.05 | 13F |
| VOR | Vor Biopharma Inc. | 0.01% | 633,848 | $1,958,590 | No Change | $3.09 | 13F | |
| KALA | Kala Pharmaceuticals, Inc. | 0.00985% | 116,213 | $1,695,548 | 39,400 | 51.29% | $14.59 | 13F |
| CATX | Perspective Therapeutics, Inc. | 0.00900% | 2,319,286 | $1,549,283 | 2,319,286 | New | $0.67 | 13F |
| AGLE | Aeglea BioTherapeutics, Inc. | 0.00893% | 3,410,106 | $1,536,253 | No Change | $0.45 | 13F | |
| FGEN | FibroGen, Inc. | 0.00373% | 238,084 | $642,827 | -2,399,300 | -90.97% | $2.7 | 13F |
| NKTX | Nkarta, Inc. | 0.00345% | 271,329 | $594,211 | -128,671 | -32.17% | $2.19 | 13F |
| TARA | Protara Therapeutics, Inc. | 0.00277% | 199,671 | $477,214 | No Change | $2.39 | 13F | |
| GTH | Genetron Holdings Limited | 0.00246% | 455,306 | $423,480 | No Change | $0.93 | 13F | |
| FHTX | Foghorn Therapeutics Inc. | 0.00184% | 45,027 | $316,990 | No Change | $7.04 | 13F | |
| VINC | Vincerx Pharma, Inc. | 0.00170% | 225,579 | $293,253 | -15,800 | -6.55% | $1.3 | 13F |
| SRZNW | Surrozen, Inc. | 0.00027% | 833,333 | $46,000 | No Change | $0.06 | 13F | |
| ATRA | Atara Biotherapeutics, Inc. | -744,186 | Exited | 13F | ||||
| BLCM | Bellicum Pharmaceuticals, Inc. | -249,123 | Exited | 13F | ||||
| BPMC | Blueprint Medicines Corporation | -333,665 | Exited | 13F | ||||
| LPTX | Leap Therapeutics, Inc. | -7,425,570 | Exited | 13F | ||||
| TLIS | Talis Biomedical Corporation | -7,624,835 | Exited | 13F | ||||
| TCRR | TCR2 Therapeutics Inc. | -753,064 | Exited | 13F | ||||
| VSTM | Verastem, Inc. | -25,521,447 | Exited | 13F | ||||
| VSTM | Verastem, Inc. | -1,336,485 | Exited | 13G | ||||
| VERU | Veru Inc. | -1,609,579 | Exited | 13F |
We have created a comprehensive group of tools that allows you to estimate the intrinsic value of investments.