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| Stock | Company | % Portfolio | Shares Held | Market Value | Change in Shares | % Change | Quarter End Price | Source |
|---|---|---|---|---|---|---|---|---|
| SVA | SINOVAC BIOTECH LTD | 6.68% | 2,718,735 | $340,000,000 | No Change | $125.06 | 13F | |
| ELVN | ENLIVEN THERAPEUTICS INC | 3.87% | 8,996,213 | $197,017,065 | 8,996,213 | New | $21.9 | 13F |
| BSX | BOSTON SCIENTIFIC CORP | 3.72% | 3,790,000 | $189,613,700 | -108,200 | -2.78% | $50.03 | 13F |
| HUM | HUMANA INC | 3.32% | 348,700 | $169,279,902 | No Change | $485.46 | 13F | |
| BMY | BRISTOL-MYERS SQUIBB CO | 3.19% | 2,340,000 | $162,185,400 | -244,900 | -9.47% | $69.31 | 13F |
| ISRG | INTUITIVE SURGICAL INC | 3.11% | 620,500 | $158,519,135 | No Change | $255.47 | 13F | |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 3.08% | 1,615,210 | $157,063,020 | No Change | $97.24 | 13F | |
| THRX | THESEUS PHARMACEUTICALS INC | 3.01% | 17,233,668 | $153,034,972 | No Change | $8.88 | 13F | |
| BIIB | BIOGEN INC | 2.76% | 505,000 | $140,405,150 | 246,800 | 95.58% | $278.03 | 13F |
| UNH | UNITEDHEALTH GROUP INC | 2.56% | 276,000 | $130,434,840 | -104,500 | -27.46% | $472.59 | 13F |
| SWTX | SpringWorks Therapeutics, Inc. | 2.49% | 4,178,588 | $128,408,009 | -320,312 | -7.12% | 13D | |
| SRPT | SAREPTA THERAPEUTICS INC | 2.34% | 865,100 | $119,236,733 | -107,200 | -11.03% | $137.83 | 13F |
| SYK | STRYKER CORPORATION | 2.06% | 367,600 | $104,938,772 | -113,400 | -23.58% | $285.47 | 13F |
| EWTX | EDGEWISE THERAPEUTICS INC | 1.91% | 14,567,176 | $97,163,064 | No Change | $6.67 | 13F | |
| EVH | EVOLENT HEALTH INC | 1.85% | 2,895,632 | $93,963,258 | 70,800 | 2.51% | $32.45 | 13F |
| TERN | TERNS PHARMACEUTICALS INC | 1.77% | 7,619,135 | $90,210,558 | No Change | $11.84 | 13F | |
| TMO | THERMO FISHER SCIENTIFIC INC | 1.67% | 147,800 | $85,187,486 | -54,400 | -26.9% | $576.37 | 13F |
| VRNA | Verona Pharma plc | 1.61% | 4,123,091 | $82,791,667 | -137,600 | -3.23% | Form 4 | |
| IONS | IONIS PHARMACEUTICALS INC | 1.49% | 2,124,500 | $75,929,630 | 130,900 | 6.57% | $35.74 | 13F |
| CMPX | COMPASS THERAPEUTICS INC | 1.44% | 22,362,850 | $73,126,520 | No Change | $3.27 | 13F | |
| THC | TENET HEALTHCARE CORP | 1.42% | 1,220,300 | $72,510,226 | No Change | $59.42 | 13F | |
| KROS | KEROS THERAPEUTICS INC | 1.41% | 1,679,417 | $71,711,106 | No Change | $42.7 | 13F | |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1.25% | 3,950,796 | $63,449,784 | 753,920 | 23.58% | $16.06 | 13F |
| LLY | LILLY ELI & CO | 1.25% | 186,000 | $63,876,120 | 186,000 | New | $343.42 | 13F |
| BAX | BAXTER INTL INC | 1.24% | 1,562,000 | $63,354,720 | 1,562,000 | New | $40.56 | 13F |
| PRLD | Prelude Therapeutics Inc | 1.19% | 10,646,056 | $61,214,822 | 606,365 | 6.04% | Form 4 | |
| VECT | VectivBio Holding AG | 1.19% | 5,156,561 | $61,363,076 | No Change | 13D | ||
| APLS | APELLIS PHARMACEUTICALS INC | 1.18% | 910,200 | $60,036,792 | 910,200 | New | $65.96 | 13F |
| SIBN | SI-BONE INC | 1.13% | 2,919,454 | $57,425,660 | -448,546 | -13.32% | $19.67 | 13F |
| SPRY | ARS PHARMACEUTICALS INC | 1.12% | 8,740,887 | $56,903,174 | No Change | $6.51 | 13F | |
| VRTX | VERTEX PHARMACEUTICALS INC | 1.10% | 177,600 | $55,956,432 | -93,900 | -34.59% | $315.07 | 13F |
| IKNA | IKENA ONCOLOGY INC | 1.06% | 11,895,652 | $53,820,418 | -252,225 | -2.08% | $4.52 | 13F |
| NTRA | NATERA INC | 1.06% | 973,581 | $54,053,217 | -972,772 | -49.98% | $55.52 | 13F |
| EW | EDWARDS LIFESCIENCES CORP | 1.02% | 630,000 | $52,119,900 | -230,500 | -26.79% | $82.73 | 13F |
| SCPH | SCPHARMACEUTICALS INC | 0.99% | 5,559,528 | $50,424,919 | No Change | $9.07 | 13F | |
| NBIX | NEUROCRINE BIOSCIENCES INC | 0.97% | 489,000 | $49,496,580 | -198,700 | -28.89% | $101.22 | 13F |
| IRON | DISC MEDICINE INC | 0.94% | 2,269,637 | $48,093,608 | 108,696 | 5.03% | $21.19 | 13F |
| KDNY | CHINOOK THERAPEUTICS INC | 0.92% | 2,029,300 | $46,978,295 | No Change | $23.15 | 13F | |
| XTNT | Xtant Medical Holdings, Inc. | 0.88% | 73,114,592 | $45,331,047 | No Change | 13D | ||
| ACET | ADICET BIO INC | 0.84% | 7,447,140 | $42,895,526 | No Change | $5.76 | 13F | |
| QURE | UNIQURE NV | 0.82% | 2,064,455 | $41,578,124 | 316,900 | 18.13% | $20.14 | 13F |
| XENE | XENON PHARMACEUTICALS INC | 0.81% | 1,149,100 | $41,126,289 | No Change | $35.79 | 13F | |
| TVTX | TRAVERE THERAPEUTICS INC | 0.77% | 1,744,300 | $39,229,307 | 491,170 | 39.2% | $22.49 | 13F |
| MRSN | MERSANA THERAPEUTICS INC | 0.73% | 9,011,437 | $37,037,006 | No Change | $4.11 | 13F | |
| BLU | BELLUS HEALTH INC NEW | 0.72% | 5,108,900 | $36,755,893 | 400,000 | 8.49% | $7.19 | 13F |
| SNDX | SYNDAX PHARMACEUTICALS INC | 0.71% | 1,711,675 | $36,150,576 | -294,825 | -14.69% | $21.12 | 13F |
| JANX | JANUX THERAPEUTICS INC | 0.67% | 2,836,386 | $34,320,271 | No Change | $12.1 | 13F | |
| MRTX | MIRATI THERAPEUTICS INC | 0.67% | 913,650 | $33,969,507 | -370,042 | -28.83% | $37.18 | 13F |
| PGNY | PROGYNY INC | 0.65% | 1,037,912 | $33,337,733 | 2,912 | 0.28% | $32.12 | 13F |
| RPTX | REPARE THERAPEUTICS INC | 0.64% | 3,322,488 | $32,693,282 | No Change | $9.84 | 13F | |
| ABCL | ABCELLERA BIOLOGICS INC | 0.62% | 4,180,768 | $31,522,991 | No Change | $7.54 | 13F | |
| ALPN | ALPINE IMMUNE SCIENCES INC | 0.62% | 4,081,592 | $31,509,890 | No Change | $7.72 | 13F | |
| PMVP | PMV PHARMACEUTICALS INC | 0.61% | 6,563,077 | $31,305,877 | No Change | $4.77 | 13F | |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 0.56% | 4,707,458 | $28,762,568 | 2,700,000 | 134.5% | $6.11 | 13F |
| PCVX | VAXCYTE INC | 0.54% | 729,439 | $27,339,374 | -553,687 | -43.15% | $37.48 | 13F |
| RCM | R1 RCM INC | 0.52% | 1,750,000 | $26,250,000 | 1,750,000 | New | $15 | 13F |
| TELA | TELA Bio, Inc. | 0.52% | 2,835,542 | $26,682,450 | -192,000 | -6.34% | Form 4 | |
| TSVT | 2SEVENTY BIO INC | 0.48% | 2,391,628 | $24,394,606 | 1,350,328 | 129.68% | $10.2 | 13F |
| AMLX | AMYLYX PHARMACEUTICALS INC | 0.47% | 813,500 | $23,868,090 | 813,500 | New | $29.34 | 13F |
| THRD | THIRD HARMONIC BIO INC | 0.47% | 5,779,071 | $23,809,773 | No Change | $4.12 | 13F | |
| RAPT | RAPT THERAPEUTICS INC | 0.45% | 1,251,070 | $22,957,135 | No Change | $18.35 | 13F | |
| HZNP | HORIZON THERAPEUTICS PUB L | 0.43% | 200,000 | $21,828,000 | 29,000 | 16.96% | $109.14 | 13F |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 0.41% | 1,914,479 | $21,059,269 | -545,629 | -22.18% | $11 | 13F |
| XBI | SPDR SER TR | 0.41% | 274,000 | $20,881,540 | 197,600 | 258.64% | $76.21 | 13F |
| REGN | REGENERON PHARMACEUTICALS | 0.39% | 24,000 | $19,720,080 | 24,000 | New | $821.67 | 13F |
| RXST | RXSIGHT INC | 0.39% | 1,202,833 | $20,063,254 | No Change | $16.68 | 13F | |
| VTYX | VENTYX BIOSCIENCES INC | 0.38% | 585,000 | $19,597,500 | -340,000 | -36.76% | $33.5 | 13F |
| NPCE | NEUROPACE INC | 0.37% | 4,012,281 | $18,616,984 | No Change | $4.64 | 13F | |
| AMGN | AMGEN INC | 0.36% | 76,700 | $18,542,225 | 76,700 | New | $241.75 | 13F |
| GRCL | GRACELL BIOTECHNOLOGIES INC | 0.35% | 9,497,774 | $17,665,860 | 1,612,904 | 20.46% | $1.86 | 13F |
| KZR | KEZAR LIFE SCIENCES INC | 0.34% | 5,463,000 | $17,099,190 | 878,678 | 19.17% | $3.13 | 13F |
| ARGX | ARGENX SE | 0.33% | 44,500 | $16,579,810 | 28,300 | 174.69% | $372.58 | 13F |
| APLM | APOLLOMICS INC | 0.31% | 662,561 | $16,033,976 | 662,561 | New | $24.2 | 13F |
| AVTE | AEROVATE THERAPEUTICS INC | 0.30% | 756,930 | $15,267,278 | -2,610 | -0.34% | $20.17 | 13F |
| DBTX | DECIBEL THERAPEUTICS INC | 0.29% | 4,945,192 | $14,934,480 | No Change | $3.02 | 13F | |
| BAX | BAXTER INTL INC (Call) | 0.28% | 350,000 | $14,196,000 | 350,000 | New | $40.56 | 13F |
| FOLD | AMICUS THERAPEUTICS INC | 0.26% | 1,171,000 | $12,986,390 | 655,000 | 126.94% | $11.09 | 13F |
| FUSN | Fusion Pharmaceuticals Inc. | 0.26% | 2,930,670 | $13,246,628 | -192,100 | -6.15% | 13D | |
| GHRS | GH RESEARCH PLC | 0.26% | 1,659,015 | $13,255,530 | 36,955 | 2.28% | $7.99 | 13F |
| ALXO | ALX ONCOLOGY HLDGS INC | 0.25% | 2,871,000 | $12,976,920 | No Change | $4.52 | 13F | |
| BBIO | BRIDGEBIO PHARMA INC (PRN) | 0.25% | 20,000,000 | $12,853,200 | -10,000,000 | -33.33% | $0.64 | 13F |
| IKNA | IKENA ONCOLOGY INC | 0.22% | 3,186,166 | $10,992,273 | 252,225 | 8.6% | $3.45 | 13F |
| GDRX | GOODRX HLDGS INC | 0.21% | 1,700,000 | $10,625,000 | 1,312,433 | 338.63% | $6.25 | 13F |
| VERA | VERA THERAPEUTICS INC | 0.21% | 1,362,400 | $10,572,224 | 1,362,400 | New | $7.76 | 13F |
| BCAB | BIOATLA INC | 0.20% | 3,861,000 | $10,347,480 | 3,528,628 | 1061.65% | $2.68 | 13F |
| SRPT | SAREPTA THERAPEUTICS INC (Call) | 0.20% | 75,000 | $10,337,250 | 75,000 | New | $137.83 | 13F |
| BBIO | BRIDGEBIO PHARMA INC (PRN) | 0.19% | 12,500,000 | $9,468,750 | -7,500,000 | -37.5% | $0.76 | 13F |
| PASG | PASSAGE BIO INC | 0.17% | 8,931,999 | $8,554,175 | No Change | $0.96 | 13F | |
| ORIC | ORIC PHARMACEUTICALS INC | 0.15% | 1,374,468 | $7,834,468 | -233,100 | -14.5% | $5.7 | 13F |
| XBI | SPDR SER TR (Call) | 0.15% | 100,000 | $7,621,000 | 100,000 | New | $76.21 | 13F |
| PTGX | PROTAGONIST THERAPEUTICS INC | 0.14% | 301,000 | $6,923,000 | 301,000 | New | $23 | 13F |
| YS | YS BIOPHARMA CO LTD | 0.14% | 4,298,464 | $6,877,542 | 4,298,464 | New | $1.6 | 13F |
| VSTM | VERASTEM INC | 0.13% | 16,503,237 | $6,852,144 | No Change | $0.42 | 13F | |
| IMTX | IMMATICS N.V | 0.13% | 947,248 | $6,536,011 | 947,248 | New | $6.9 | 13F |
| IVVD | INVIVYD INC | 0.12% | 5,270,400 | $6,324,480 | No Change | $1.2 | 13F | |
| CRVS | CORVUS PHARMACEUTICALS INC | 0.12% | 6,943,654 | $6,318,725 | No Change | $0.91 | 13F | |
| CGEM | CULLINAN ONCOLOGY INC | 0.12% | 605,387 | $6,193,109 | -31,900 | -5.01% | $10.23 | 13F |
| NTLA | INTELLIA THERAPEUTICS INC | 0.12% | 164,627 | $6,135,648 | 164,627 | New | $37.27 | 13F |
| KNTE | Kinnate Biopharma Inc. | 0.11% | 1,902,938 | $5,366,285 | -3,240,691 | -63.00% | Form 4 | |
| MREO | MEREO BIOPHARMA GROUP PLC | 0.11% | 7,747,891 | $5,476,984 | -2,857,631 | -26.94% | $0.71 | 13F |
| MRTX | MIRATI THERAPEUTICS INC (Call) | 0.11% | 150,000 | $5,577,000 | 150,000 | New | $37.18 | 13F |
| HZNP | HORIZON THERAPEUTICS PUB L (Put) | 0.11% | 50,000 | $5,457,000 | 50,000 | New | $109.14 | 13F |
| XFOR | X4 PHARMACEUTICALS INC | 0.10% | 5,817,726 | $5,061,422 | No Change | $0.87 | 13F | |
| GLTO | Galecto, Inc. | 0.09% | 2,417,787 | $4,763,040 | -1,673,150 | -40.90% | Form 4 | |
| VIGL | VIGIL NEUROSCIENCE INC | 0.09% | 448,891 | $4,394,643 | No Change | $9.79 | 13F | |
| NXTC | NEXTCURE INC | 0.08% | 2,711,013 | $4,012,299 | No Change | $1.48 | 13F | |
| SRRK | SCHOLAR ROCK HLDG CORP | 0.08% | 515,000 | $4,120,000 | -364,003 | -41.41% | $8 | 13F |
| CMMB | CHEMOMAB THERAPEUTICS LTD | 0.07% | 2,241,274 | $3,563,626 | -336,900 | -13.07% | $1.59 | 13F |
| EPIX | ESSA PHARMA INC | 0.07% | 1,198,337 | $3,559,061 | 833,037 | 228.04% | $2.97 | 13F |
| SYBX | SYNLOGIC INC | 0.07% | 6,029,995 | $3,810,957 | No Change | $0.63 | 13F | |
| TARA | PROTARA THERAPEUTICS INC | 0.05% | 793,558 | $2,483,837 | -37,083 | -4.46% | $3.13 | 13F |
| AFIB | ACUTUS MED INC | 0.04% | 2,648,386 | $1,996,883 | No Change | $0.75 | 13F | |
| BOLT | BOLT BIOTHERAPEUTICS INC | 0.04% | 1,541,000 | $2,141,990 | 769,941 | 99.86% | $1.39 | 13F |
| RVNC | REVANCE THERAPEUTICS INC | 0.03% | 50,000 | $1,610,500 | 50,000 | New | $32.21 | 13F |
| PHGE | BIOMX INC | 0.02% | 3,161,489 | $964,254 | 348,000 | 12.37% | $0.3 | 13F |
| HRTX | HERON THERAPEUTICS INC | 0.02% | 802,700 | $1,212,077 | 802,700 | New | $1.51 | 13F |
| MRSN | MERSANA THERAPEUTICS INC (Call) | 0.02% | 210,700 | $865,977 | 210,700 | New | $4.11 | 13F |
| AGLE | AEGLEA BIOTHERAPEUTICS INC | 0.01% | 1,797,221 | $521,194 | No Change | $0.29 | 13F | |
| NKTR | NEKTAR THERAPEUTICS | 0.01% | 1,034,059 | $726,840 | 1,034,059 | New | $0.7 | 13F |
| OMIC | SINGULAR GENOMICS SYSTEMS IN | 0.01% | 540,697 | $654,243 | No Change | $1.21 | 13F | |
| HARP | HARPOON THERAPEUTICS INC | 0.00908% | 621,218 | $462,310 | -895,278 | -59.04% | $0.74 | 13F |
| ALT | ALTIMMUNE INC (Call) | 0.00829% | 100,000 | $422,000 | 100,000 | New | $4.22 | 13F |
| NKTR | NEKTAR THERAPEUTICS (Call) | 0.00752% | 545,000 | $383,081 | 545,000 | New | $0.7 | 13F |
| ALT | ALTIMMUNE INC | 0.00419% | 50,600 | $213,532 | 50,600 | New | $4.22 | 13F |
| ACRS | ACLARIS THERAPEUTICS INC | -2,758,434 | Exited | 13F | ||||
| AMRX | AMNEAL PHARMACEUTICALS INC | -1,583,490 | Exited | 13F | ||||
| APLT | APPLIED THERAPEUTICS INC | -3,050,921 | Exited | 13F | ||||
| BNTX | BIONTECH SE | -36,300 | Exited | 13F | ||||
| CINC | CINCOR PHARMA INC | -1,906,000 | Exited | 13F | ||||
| CYBN | CYBIN INC | -5,386,299 | Exited | 13F | ||||
| ETNB | 89BIO INC | -3,658,869 | Exited | 13F | ||||
| EYPT | EYEPOINT PHARMACEUTICALS INC | -487,642 | Exited | 13F | ||||
| GRAY | GRAYBUG VISION INC | -4,163,347 | Exited | 13F | ||||
| IMRA | IMARA INC | -4,386,568 | Exited | 13F | ||||
| MACK | MERRIMACK PHARMACEUTICALS IN | -73,600 | Exited | 13F | ||||
| MRNA | MODERNA INC | -82,550 | Exited | 13F | ||||
| GLUE | MONTE ROSA THERAPEUTICS INC | -27,369 | Exited | 13F | ||||
| PFE | PFIZER INC | -1,393,600 | Exited | 13F | ||||
| PYXS | PYXIS ONCOLOGY INC | -848,252 | Exited | 13F | ||||
| SNY | SANOFI (Call) | -100,000 | Exited | 13F | ||||
| SGEN | SEAGEN INC | -913,812 | Exited | 13F |
We have created a comprehensive group of tools that allows you to estimate the intrinsic value of investments.