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| Stock | Company | % Portfolio | Shares Held | Market Value | Change in Shares | % Change | Quarter End Price | Source |
|---|---|---|---|---|---|---|---|---|
| SVA | SINOVAC BIOTECH LTD | 6.74% | 2,718,735 | $340,000,000 | No Change | $125.06 | 13F | |
| LLY | ELI LILLY & CO | 6.06% | 337,600 | $305,656,288 | -23,200 | -6.43% | $905.38 | 13F |
| EWTX | EDGEWISE THERAPEUTICS INC | 5.36% | 15,021,721 | $270,541,195 | No Change | $18.01 | 13F | |
| BSX | BOSTON SCIENTIFIC CORP | 5.00% | 3,273,000 | $252,053,730 | No Change | $77.01 | 13F | |
| ISRG | INTUITIVE SURGICAL INC | 4.35% | 493,100 | $219,355,535 | No Change | $444.85 | 13F | |
| BIIB | BIOGEN INC | 4.14% | 900,900 | $208,846,638 | No Change | $231.82 | 13F | |
| ELVN | ENLIVEN THERAPEUTICS INC | 3.69% | 7,959,538 | $186,014,403 | -1,038,800 | -11.54% | $23.37 | 13F |
| MRK | MERCK & CO INC | 3.23% | 1,316,000 | $162,920,800 | No Change | $123.8 | 13F | |
| THC | TENET HEALTHCARE CORP | 3.09% | 1,173,300 | $156,084,099 | No Change | $133.03 | 13F | |
| IONS | IONIS PHARMACEUTICALS INC | 2.24% | 2,372,333 | $113,065,391 | 359,300 | 17.85% | $47.66 | 13F |
| SPRY | ARS Pharmaceuticals, Inc. | 2.13% | 8,288,510 | $107,750,630 | -952,377 | -10.31% | Form 4 | |
| SRPT | SAREPTA THERAPEUTICS INC | 2.02% | 646,000 | $102,068,000 | -51,500 | -7.38% | $158 | 13F |
| ELV | ELEVANCE HEALTH INC | 1.81% | 168,100 | $91,086,666 | No Change | $541.86 | 13F | |
| SYK | STRYKER CORPORATION | 1.81% | 269,000 | $91,527,250 | No Change | $340.25 | 13F | |
| ARGX | ARGENX SE | 1.78% | 209,100 | $89,921,364 | 57,500 | 37.93% | $430.04 | 13F |
| IRON | DISC MEDICINE INC | 1.60% | 1,785,571 | $80,475,685 | 83,334 | 4.9% | $45.07 | 13F |
| JANX | Janux Therapeutics, Inc. | 1.59% | 1,965,266 | $79,789,800 | -1,014,562 | -34.05% | 13D | |
| THRD | THIRD HARMONIC BIO INC | 1.49% | 5,779,071 | $75,127,923 | No Change | $13 | 13F | |
| NTRA | NATERA INC | 1.48% | 687,500 | $74,449,375 | -211,931 | -23.56% | $108.29 | 13F |
| TMO | THERMO FISHER SCIENTIFIC INC | 1.45% | 132,000 | $72,996,000 | No Change | $553 | 13F | |
| VRTX | VERTEX PHARMACEUTICALS INC | 1.40% | 151,000 | $70,776,720 | 28,300 | 23.06% | $468.72 | 13F |
| SWTX | SPRINGWORKS THERAPEUTICS INC | 1.27% | 1,707,331 | $64,315,159 | No Change | $37.67 | 13F | |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1.22% | 448,200 | $61,703,694 | 25,100 | 5.93% | $137.67 | 13F |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 1.21% | 250,300 | $60,822,900 | 250,300 | New | $243 | 13F |
| PCVX | VAXCYTE INC | 1.19% | 795,900 | $60,098,409 | -270,231 | -25.35% | $75.51 | 13F |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1.14% | 1,280,800 | $57,367,032 | -104,200 | -7.52% | $44.79 | 13F |
| UNH | UNITEDHEALTH GROUP INC | 1.13% | 112,000 | $57,037,120 | 42,000 | 60% | $509.26 | 13F |
| AVBP | ARRIVENT BIOPHARMA INC | 1.11% | 3,027,328 | $56,156,934 | No Change | $18.55 | 13F | |
| ICLR | ICON PLC | 1.08% | 174,100 | $54,575,127 | No Change | $313.47 | 13F | |
| APLS | APELLIS PHARMACEUTICALS INC | 0.99% | 1,302,800 | $49,975,408 | 5,000 | 0.39% | $38.36 | 13F |
| EVH | EVOLENT HEALTH INC | 0.99% | 2,605,615 | $49,819,359 | No Change | $19.12 | 13F | |
| TERN | Terns Pharmaceuticals, Inc. | 0.96% | 4,839,412 | $48,394,120 | -2,779,723 | -36.48% | Form 4 | |
| CYTK | CYTOKINETICS INC | 0.87% | 812,906 | $44,043,247 | 130,206 | 19.07% | $54.18 | 13F |
| AMGN | AMGEN INC | 0.84% | 134,900 | $42,149,505 | 71,500 | 112.78% | $312.45 | 13F |
| SIBN | SI-BONE INC | 0.83% | 3,229,977 | $41,763,603 | 55,456 | 1.75% | $12.93 | 13F |
| PRLD | PRELUDE THERAPEUTICS INC | 0.82% | 10,909,256 | $41,564,265 | No Change | $3.81 | 13F | |
| VRNA | VERONA PHARMA PLC | 0.82% | 2,861,801 | $41,381,642 | -536,266 | -15.78% | $14.46 | 13F |
| ITGR | INTEGER HLDGS CORP | 0.80% | 349,221 | $40,436,300 | 349,221 | New | $115.79 | 13F |
| QTTB | Q32 BIO INC | 0.80% | 2,252,987 | $40,441,117 | No Change | $17.95 | 13F | |
| XTNT | Xtant Medical Holdings, Inc. | 0.79% | 73,114,592 | $40,213,026 | No Change | 13D | ||
| KROS | Keros Therapeutics, Inc. | 0.78% | 899,212 | $39,574,320 | -369,522 | -29.13% | Form 4 | |
| SNDX | SYNDAX PHARMACEUTICALS INC | 0.78% | 1,925,300 | $39,526,409 | 176,300 | 10.08% | $20.53 | 13F |
| GERN | GERON CORP | 0.75% | 8,930,252 | $37,864,268 | -3,963,359 | -30.74% | $4.24 | 13F |
| XENE | XENON PHARMACEUTICALS INC | 0.67% | 862,362 | $33,623,494 | 312,362 | 56.79% | $38.99 | 13F |
| DXCM | DEXCOM INC | 0.65% | 289,900 | $32,868,862 | 149,600 | 106.63% | $113.38 | 13F |
| IKNA | IKENA ONCOLOGY INC | 0.64% | 12,048,773 | $32,149,678 | No Change | $2.67 | 13F | |
| RNA | AVIDITY BIOSCIENCES INC | 0.57% | 706,475 | $28,859,504 | -287,625 | -28.93% | $40.85 | 13F |
| RYTM | RHYTHM PHARMACEUTICALS INC | 0.57% | 704,842 | $28,940,813 | No Change | $41.06 | 13F | |
| EXAS | EXACT SCIENCES CORP | 0.56% | 672,416 | $28,409,576 | 532,016 | 378.93% | $42.25 | 13F |
| NPCE | NEUROPACE INC | 0.51% | 3,406,335 | $25,751,893 | -597,632 | -14.93% | $7.56 | 13F |
| DYN | DYNE THERAPEUTICS INC | 0.50% | 708,400 | $24,999,436 | No Change | $35.29 | 13F | |
| REGN | REGENERON PHARMACEUTICALS | 0.48% | 22,800 | $23,963,484 | No Change | $1051.03 | 13F | |
| VERA | VERA THERAPEUTICS INC | 0.48% | 675,872 | $24,453,049 | No Change | $36.18 | 13F | |
| MLYS | MINERALYS THERAPEUTICS INC | 0.47% | 2,021,424 | $23,650,661 | No Change | $11.7 | 13F | |
| SCPH | scPharmaceuticals Inc. | 0.46% | 5,806,670 | $23,226,680 | 247,142 | 4.45% | Form 4 | |
| IMTX | IMMATICS N.V | 0.46% | 2,006,381 | $23,314,147 | 236,673 | 13.37% | $11.62 | 13F |
| HRTX | HERON THERAPEUTICS INC | 0.45% | 6,512,866 | $22,795,031 | -3,598,684 | -35.59% | $3.5 | 13F |
| CMPX | COMPASS THERAPEUTICS INC | 0.44% | 22,362,850 | $22,362,850 | No Change | $1 | 13F | |
| MORF | MORPHIC HLDG INC | 0.41% | 612,500 | $20,867,875 | 54,000 | 9.67% | $34.07 | 13F |
| VIR | VIR BIOTECHNOLOGY INC | 0.41% | 2,320,102 | $20,648,908 | 1,680,102 | 262.52% | $8.9 | 13F |
| CGEM | CULLINAN THERAPEUTICS INC | 0.40% | 1,147,655 | $20,015,103 | 630,049 | 121.72% | $17.44 | 13F |
| SLRN | ACELYRIN INC | 0.35% | 4,001,711 | $17,647,546 | No Change | $4.41 | 13F | |
| APGE | APOGEE THERAPEUTICS INC | 0.30% | 379,130 | $14,918,766 | -339,771 | -47.26% | $39.35 | 13F |
| NMRA | NEUMORA THERAPEUTICS INC. | 0.29% | 1,500,000 | $14,745,000 | No Change | $9.83 | 13F | |
| ACET | ADICET BIO INC | 0.27% | 11,447,140 | $13,851,039 | No Change | $1.21 | 13F | |
| ADCT | ADC THERAPEUTICS SA | 0.27% | 4,316,824 | $13,641,164 | 4,316,824 | New | $3.16 | 13F |
| ABCL | ABCELLERA BIOLOGICS INC | 0.25% | 4,180,768 | $12,375,073 | No Change | $2.96 | 13F | |
| CRVS | CORVUS PHARMACEUTICALS INC | 0.25% | 6,943,654 | $12,637,450 | No Change | $1.82 | 13F | |
| TYRA | TYRA BIOSCIENCES INC | 0.24% | 768,638 | $12,290,522 | No Change | $15.99 | 13F | |
| ALXO | ALX ONCOLOGY HLDGS INC | 0.23% | 1,894,462 | $11,423,606 | -823,508 | -30.3% | $6.03 | 13F |
| RPTX | REPARE THERAPEUTICS INC | 0.22% | 3,322,488 | $10,964,210 | No Change | $3.3 | 13F | |
| TELA | TELA Bio, Inc. | 0.22% | 2,407,242 | $10,928,879 | -50,300 | -2.05% | Form 4 | |
| PMVP | PMV PHARMACEUTICALS INC | 0.21% | 6,475,291 | $10,489,971 | No Change | $1.62 | 13F | |
| SOLV | SOLVENTUM CORP (Call) | 0.21% | 200,000 | $10,576,000 | 200,000 | New | $52.88 | 13F |
| LXRX | LEXICON PHARMACEUTICALS INC | 0.19% | 5,846,100 | $9,821,448 | 2,304,100 | 65.05% | $1.68 | 13F |
| LYEL | LYELL IMMUNOPHARMA INC | 0.18% | 6,405,098 | $9,287,392 | 6,205,598 | 3110.58% | $1.45 | 13F |
| SRRK | SCHOLAR ROCK HLDG CORP | 0.18% | 1,074,382 | $8,949,602 | -2,500,250 | -69.94% | $8.33 | 13F |
| MRUS | MERUS N V | 0.18% | 156,100 | $9,236,437 | 156,100 | New | $59.17 | 13F |
| PASG | PASSAGE BIO INC | 0.16% | 10,124,576 | $8,040,938 | No Change | $0.79 | 13F | |
| SRPT | SAREPTA THERAPEUTICS INC (Call) | 0.16% | 50,000 | $7,900,000 | 50,000 | New | $158 | 13F |
| TSBX | TURNSTONE BIOLOGICS CORP | 0.16% | 3,099,265 | $8,120,074 | No Change | $2.62 | 13F | |
| PGNY | PROGYNY INC | 0.15% | 259,900 | $7,435,739 | 146,600 | 129.39% | $28.61 | 13F |
| CCCC | C4 THERAPEUTICS INC | 0.14% | 1,513,058 | $6,990,328 | 1,513,058 | New | $4.62 | 13F |
| PFE | PFIZER INC (Call) | 0.14% | 250,000 | $6,995,000 | 250,000 | New | $27.98 | 13F |
| IKNA | IKENA ONCOLOGY INC | 0.12% | 3,539,358 | $5,839,941 | No Change | $1.65 | 13F | |
| FOLD | AMICUS THERAPEUTICS INC | 0.11% | 570,300 | $5,657,376 | No Change | $9.92 | 13F | |
| NSPR | INSPIREMD INC | 0.11% | 2,133,405 | $5,323,485 | No Change | $2.5 | 13F | |
| KRYS | KRYSTAL BIOTECH INC | 0.11% | 29,966 | $5,502,956 | -7,200 | -19.37% | $183.64 | 13F |
| CATX | PERSPECTIVE THERAPEUTICS INC | 0.10% | 492,670 | $4,911,920 | 492,670 | New | $9.97 | 13F |
| GPCR | STRUCTURE THERAPEUTICS INC | 0.10% | 125,000 | $4,908,750 | 125,000 | New | $39.27 | 13F |
| PHGE | BIOMX INC | 0.09% | 13,773,653 | $4,629,325 | 9,256,064 | 204.89% | $0.34 | 13F |
| FATE | FATE THERAPEUTICS INC | 0.09% | 1,355,352 | $4,445,555 | No Change | $3.28 | 13F | |
| NKTX | NKARTA INC | 0.09% | 800,000 | $4,728,000 | No Change | $5.91 | 13F | |
| VSTM | VERASTEM INC | 0.09% | 1,529,115 | $4,556,763 | No Change | $2.98 | 13F | |
| XFOR | X4 PHARMACEUTICALS INC | 0.08% | 7,133,515 | $4,137,439 | No Change | $0.58 | 13F | |
| SIBN | SI-BONE INC (Call) | 0.06% | 250,000 | $3,232,500 | No Change | $12.93 | 13F | |
| MRUS | MERUS N V (Call) | 0.06% | 50,000 | $2,958,500 | 50,000 | New | $59.17 | 13F |
| IVVD | INVIVYD INC | 0.05% | 2,425,800 | $2,668,380 | -264,500 | -9.83% | $1.1 | 13F |
| ELEV | ELEVATION ONCOLOGY INC | 0.05% | 941,275 | $2,541,443 | No Change | $2.7 | 13F | |
| GERN | GERON CORP (Call) | 0.05% | 600,000 | $2,544,000 | 600,000 | New | $4.24 | 13F |
| MIST | MILESTONE PHARMACEUTICALS IN | 0.05% | 2,000,000 | $2,640,000 | No Change | $1.32 | 13F | |
| TGTX | TG THERAPEUTICS INC | 0.05% | 133,200 | $2,369,628 | 133,200 | New | $17.79 | 13F |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 0.04% | 26,100 | $2,148,813 | -1,252,400 | -97.96% | $82.33 | 13F |
| CMMB | CHEMOMAB THERAPEUTICS LTD | 0.04% | 2,241,273 | $2,045,162 | -1 | -0.00004% | $0.91 | 13F |
| NXTC | NEXTCURE INC | 0.04% | 1,141,200 | $1,814,508 | No Change | $1.59 | 13F | |
| ORIC | ORIC PHARMACEUTICALS INC | 0.04% | 287,100 | $2,029,797 | No Change | $7.07 | 13F | |
| VIGL | VIGIL NEUROSCIENCE INC | 0.04% | 448,891 | $1,795,564 | No Change | $4 | 13F | |
| DVAX | DYNAVAX TECHNOLOGIES CORP | 0.03% | 113,500 | $1,274,605 | No Change | $11.23 | 13F | |
| KZR | KEZAR LIFE SCIENCES INC | 0.02% | 1,927,000 | $1,156,200 | No Change | $0.6 | 13F | |
| LSB | LAKESHORE BIOPHARMA CO LTD | 0.02% | 1,404,280 | $909,833 | -130,150 | -8.48% | $0.65 | 13F |
| TRAW | TRAWS PHARMA INC | 0.00926% | 1,045,261 | $466,918 | 1,045,261 | New | $0.45 | 13F |
| XERS | XERIS BIOPHARMA HOLDINGS INC | 0.00359% | 80,420 | $180,945 | No Change | $2.25 | 13F | |
| OMIC | SINGULAR GENOMICS SYSTEMS IN | 0.00302% | 18,023 | $152,294 | 18,023 | New | $8.45 | 13F |
| APLM | Apollomics Inc. | 0.00014% | 50,000 | $7,000 | -8,515,456 | -99.42% | 13D | |
| AFIB | ACUTUS MED INC | -2,648,386 | Exited | 13F | ||||
| AVTE | AEROVATE THERAPEUTICS INC | -565,374 | Exited | 13F | ||||
| ALPN | ALPINE IMMUNE SCIENCES INC | -2,680,496 | Exited | 13F | ||||
| APLS | APELLIS PHARMACEUTICALS INC (Call) | -150,000 | Exited | 13F | ||||
| ARWR | ARROWHEAD PHARMACEUTICALS IN | -739,651 | Exited | 13F | ||||
| BOLT | BOLT BIOTHERAPEUTICS INC | -1,541,000 | Exited | 13F | ||||
| CTMX | CYTOMX THERAPEUTICS INC | -3,544,578 | Exited | 13F | ||||
| ESPR | ESPERION THERAPEUTICS INC NE | -13,708,731 | Exited | 13F | ||||
| CALC | CALCIMEDICA INC | -297,380 | Exited | 13F | ||||
| CATX | PERSPECTIVE THERAPEUTICS INC | -6,505,800 | Exited | 13F | ||||
| KNTE | KINNATE BIOPHARMA INC | -8,009,729 | Exited | 13F | ||||
| PRAX | PRAXIS PRECISION MEDICINES I | -460,512 | Exited | 13F | ||||
| OMIC | SINGULAR GENOMICS SYSTEMS IN | -540,697 | Exited | 13F | ||||
| TXG | 10X GENOMICS INC | -225,200 | Exited | 13F | ||||
| VTYX | VENTYX BIOSCIENCES INC | -1,870,456 | Exited | 13F |