NEKTAR THERAPEUTICS (NKTR) symbol metrics page

Nektar Therapeutics. (NKTR) NASDAQ

$1.32 (0.03) (-2.22%)

Market Cap: $247.88M

As of 04/18/24 04:00 PM EDT. Market closed.

Nektar Therapeutics. (NKTR)
NASDAQ

$1.32
(0.03) (-2.22%)

Market Cap: $247.88M

As of 04/18/24 04:00 PM EDT. Market closed.

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nektar therapeutics is a leading biopharmaceutical company developing a robust pipeline of novel therapeutics based on its advanced polymer conjugate chemistry technology platform. nektar also partners with the top biopharmaceutical companies to bring new products to market. to date, nektar's technology and drug development expertise have enabled nine approved products for partners, which include ... read more

COMPANY PROFILE

Sector

Professional, Scientific, and Technical Services

Industry

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

CEO

Howard Robin

Full Time Employees

820

CEO Compensation (Base)

$968,921

CEO Compensation (Total)

$13.33M

URL

nektar.com

Address

455 Mission Bay Blvd S, California, San Francisco, 94158-2158.

Sector

Professional, Scientific, and Technical Services

Industry

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

CEO

Howard Robin

Full Time Employees

820

CEO Compensation (Base)

$968,921

CEO Compensation (Total)

$13.33M

URL

nektar.com

Address

455 Mission Bay Blvd S, California, San Francisco, 94158-2158.

PRICE CHART FOR NEKTAR THERAPEUTICS

YTD

MAX

From: To:

NEWS

INSIDEARBITRAGE ARTICLES

KEY STATS

Open

$1.35

Previous Close

$1.35

Days Range

$1.27 - $1.36

52 week range

$0.41 - $1.75

Volume

3,575,770

Avg. Volume (30 days)

3,508,363

Market Cap

$247.88M

Dividend Yield

P/E

(0.90)

Shares Outstanding

183,617,817

Open

$1.35

Previous Close

$1.35

Days Range

$1.27 - $1.36

52 week range

$0.41 - $1.75

Volume

3,575,770

Avg. Volume (30 days)

3,508,363

Market Cap

$247.88M

Dividend Yield

P/E

(0.90)

Shares Outstanding

183,617,817

FINANCIAL STATEMENTS FOR NEKTAR THERAPEUTICS

Open in:

INSIDER TRANSACTIONS FOR NEKTAR THERAPEUTICS

Owner	Relationship	Date	Transaction	Cost	# Shares	Value($)	Total Shares	Form 4
Zalevsky Jonathan	Chief R&D Officer	Feb 20, 2024	Sale	$0.68	9,014	6,130	265,025	Feb 22, 2024, 08:19 PM
Wilson Mark Andrew	Chief Legal Officer	Feb 20, 2024	Sale	$0.68	7,606	5,172	236,674	Feb 22, 2024, 08:17 PM
ROBIN HOWARD W	President & CEO	Feb 20, 2024	Sale	$0.68	20,033	13,622	879,889	Feb 22, 2024, 08:16 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 17, 2023	Sale	$0.49	9,646	4,727	274,039	Nov 20, 2023, 09:02 PM
Wilson Mark Andrew	Chief Legal Officer	Nov 17, 2023	Sale	$0.49	7,179	3,518	243,780	Nov 20, 2023, 09:00 PM
ROBIN HOWARD W	President & CEO	Nov 17, 2023	Sale	$0.49	19,877	9,740	899,922	Nov 20, 2023, 08:58 PM
Curet Myriam	Director	Sep 18, 2023	Sale	$0.69	4,359	3,008	27,418	Sep 20, 2023, 08:09 PM
CHESS ROBERT	Director	Sep 22, 2022	Sale	$0.67	10,200	6,834	274,773	Sep 20, 2023, 08:08 PM
Ajer Jeffrey Robert	Director	Sep 18, 2023	Sale	$0.69	4,359	3,008	34,153	Sep 20, 2023, 08:06 PM
Zalevsky Jonathan	Chief R&D Officer	Aug 16, 2023	Sale	$0.78	9,703	7,568	283,685	Aug 17, 2023, 08:08 PM
Wilson Mark Andrew	Chief Legal Officer	Aug 16, 2023	Sale	$0.78	7,221	5,632	250,959	Aug 17, 2023, 08:07 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2023	Sale	$0.78	19,998	15,598	919,799	Aug 17, 2023, 08:06 PM
WHITFIELD ROY A	Director	Jun 14, 2023	Sale	$0.57	30,000	17,100	216,250	Jun 15, 2023, 06:26 PM
Zalevsky Jonathan	Chief R&D Officer	May 16, 2023	Sale	$0.72	9,791	7,050	293,388	May 17, 2023, 08:29 PM
Wilson Mark Andrew	Chief Legal Officer	May 16, 2023	Sale	$0.72	7,543	5,431	257,680	May 17, 2023, 08:28 PM
ROBIN HOWARD W	President & CEO	May 16, 2023	Sale	$0.72	20,361	14,660	939,797	May 17, 2023, 08:27 PM
Zalevsky Jonathan	Chief R&D Officer	Feb 16, 2023	Sale	$3.00	10,484	31,452	303,179	Feb 17, 2023, 09:00 PM
Wilson Mark Andrew	Chief Legal Officer	Feb 16, 2023	Sale	$3.00	8,275	24,825	265,223	Feb 17, 2023, 08:59 PM
Thomsen Jillian B.	Chief Financial Officer	Feb 16, 2023	Sale	$3.00	10,267	30,801	313,497	Feb 17, 2023, 08:58 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2023	Sale	$3.00	19,635	58,905	960,158	Feb 17, 2023, 08:57 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 16, 2022	Sale	$3.57	13,460	48,052	313,663	Nov 18, 2022, 06:05 PM
Wilson Mark Andrew	Chief Legal Officer	Nov 16, 2022	Sale	$3.57	8,690	31,023	272,498	Nov 18, 2022, 06:04 PM
Thomsen Jillian B.	Chief Financial Officer	Nov 16, 2022	Sale	$3.57	11,095	39,609	323,764	Nov 18, 2022, 06:03 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2022	Sale	$3.57	38,014	135,710	979,793	Nov 18, 2022, 06:02 PM
Curet Myriam	Director	Sep 23, 2022	Sale	$3.16	4,198	13,266	31,777	Sep 26, 2022, 07:32 PM
Ajer Jeffrey Robert	Director	Sep 23, 2022	Sale	$3.16	4,198	13,266	38,512	Sep 26, 2022, 07:25 PM
CHESS ROBERT	Director	Sep 22, 2022	Sale	$3.19	5,100	16,269	228,179	Sep 26, 2022, 07:23 PM
EASTHAM KARIN	Director	Sep 13, 2022	Sale	$3.61	21,267	76,774	13,033	Sep 14, 2022, 06:01 PM
Zalevsky Jonathan	Chief R&D Officer	Aug 18, 2022	Sale	$4.65	73,716	342,779	327,123	Aug 19, 2022, 06:27 PM
Zalevsky Jonathan	Chief R&D Officer	Aug 16, 2022	Sale	$4.76	10,560	50,266	400,839	Aug 17, 2022, 07:41 PM
Wilson Mark Andrew	SVP & General Counsel	Aug 16, 2022	Sale	$4.76	3,189	15,180	281,188	Aug 17, 2022, 07:40 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2022	Sale	$4.76	2,006	9,549	334,859	Aug 17, 2022, 07:40 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2022	Sale	$4.76	13,759	65,493	1,017,807	Aug 17, 2022, 07:39 PM
Zalevsky Jonathan	Chief R&D Officer	May 16, 2022	Sale	$3.95	21,673	85,608	276,399	May 17, 2022, 09:40 PM
Wilson Mark Andrew	SVP & General Counsel	May 16, 2022	Sale	$3.95	3,136	12,387	117,939	May 17, 2022, 09:38 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 16, 2022	Sale	$3.95	5,841	23,072	170,427	May 17, 2022, 09:36 PM
ROBIN HOWARD W	President & CEO	May 16, 2022	Sale	$3.95	36,529	144,290	620,941	May 17, 2022, 09:35 PM
NORTHCOTT JOHN	SVP & Chief Commercial Officer	May 16, 2022	Sale	$3.95	4,592	18,138	223,210	May 17, 2022, 09:33 PM
Labrucherie Gil M	SVP, COO & CFO	May 16, 2022	Sale	$3.95	17,448	68,920	312,905	May 17, 2022, 09:32 PM
Zalevsky Jonathan	Chief R&D Officer	Feb 16, 2022	Sale	$10.95	10,912	119,486	274,122	Feb 18, 2022, 06:20 PM
Wilson Mark Andrew	SVP & General Counsel	Feb 16, 2022	Sale	$10.95	3,661	40,088	121,075	Feb 18, 2022, 06:18 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 16, 2022	Sale	$10.95	2,363	25,875	165,318	Feb 18, 2022, 06:18 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2022	Sale	$10.95	12,480	136,656	589,020	Feb 18, 2022, 06:16 PM
NORTHCOTT JOHN	SVP & Chief Commercial Officer	Feb 16, 2022	Sale	$10.95	4,852	53,129	227,802	Feb 18, 2022, 06:15 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 16, 2022	Sale	$10.95	7,579	82,990	301,603	Feb 18, 2022, 06:14 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 18, 2021	Sale	$12.69	3,000	38,070	256,682	Nov 18, 2021, 06:06 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 16, 2021	Sale	$13.16	21,149	278,321	259,682	Nov 18, 2021, 06:06 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 16, 2021	Sale	$13.16	20,869	274,636	232,084	Nov 17, 2021, 06:11 PM
Wilson Mark Andrew	SVP & General Counsel	Nov 16, 2021	Sale	$13.16	6,564	86,382	86,436	Nov 17, 2021, 06:09 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 16, 2021	Sale	$13.16	6,741	88,712	145,981	Nov 17, 2021, 06:08 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2021	Sale	$13.16	42,773	562,893	475,450	Nov 17, 2021, 06:07 PM
NORTHCOTT JOHN	SVP & Chief Commercial Officer	Nov 16, 2021	Sale	$13.16	6,061	79,763	194,854	Nov 17, 2021, 06:06 PM
GREER R SCOTT	Director	Nov 09, 2021	Option Exercise	$12.80	12,500	160,000	293,374	Nov 09, 2021, 05:05 PM
Curet Myriam	Director	Sep 22, 2021	Sale	$17.78	3,665	65,164	25,775	Sep 24, 2021, 06:14 PM
CHESS ROBERT	Director	Sep 22, 2021	Sale	$17.94	4,600	82,524	279,873	Sep 24, 2021, 06:13 PM
Ajer Jeffrey Robert	Director	Sep 22, 2021	Sale	$17.78	3,665	65,164	32,510	Sep 24, 2021, 06:12 PM
WHITFIELD ROY A	Director	Sep 16, 2021	Option Exercise	$13.80	40,000	552,000	225,850	Sep 17, 2021, 06:44 PM
CHESS ROBERT	Director	Sep 09, 2021	Option Exercise	$13.80	10,279	141,850	284,552	Sep 10, 2021, 06:03 PM
CHESS ROBERT	Director	Sep 08, 2021	Option Exercise	$13.80	8,000	110,400	282,273	Sep 10, 2021, 06:03 PM
CHESS ROBERT	Director	Sep 09, 2021	Sale	$16.02	10,279	164,670	274,273	Sep 10, 2021, 06:03 PM
CHESS ROBERT	Director	Sep 08, 2021	Sale	$16.00	8,000	128,000	274,273	Sep 10, 2021, 06:03 PM
GREER R SCOTT	Director	Aug 31, 2021	Option Exercise	$12.70	45,000	571,500	270,674	Aug 31, 2021, 06:26 PM
Zalevsky Jonathan	Chief R&D Officer	Aug 16, 2021	Sale	$13.83	7,662	105,965	212,803	Aug 18, 2021, 07:04 PM
Wilson Mark Andrew	SVP & General Counsel	Aug 16, 2021	Sale	$13.83	1,910	26,415	72,900	Aug 18, 2021, 07:02 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2021	Sale	$13.83	11,515	159,252	424,123	Aug 18, 2021, 07:01 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2021	Sale	$13.83	13,339	184,478	137,822	Aug 18, 2021, 07:00 PM
NORTHCOTT JOHN	SVP & Chief Commercial Officer	Aug 16, 2021	Sale	$13.83	6,192	85,635	200,915	Aug 18, 2021, 06:59 PM
Labrucherie Gil M	SVP, COO & CFO	Aug 17, 2021	Sale	$13.56	3,000	40,680	240,231	Aug 18, 2021, 06:58 PM
Labrucherie Gil M	SVP, COO & CFO	Aug 16, 2021	Sale	$13.83	7,867	108,801	243,231	Aug 18, 2021, 06:58 PM
CHESS ROBERT	Director	Jul 22, 2021	Option Exercise	$13.80	91	1,256	280,664	Jul 22, 2021, 07:13 PM
CHESS ROBERT	Director	Jul 21, 2021	Option Exercise	$13.80	3,524	48,631	284,097	Jul 22, 2021, 07:13 PM
CHESS ROBERT	Director	Jul 20, 2021	Option Exercise	$13.80	2,106	29,063	282,679	Jul 22, 2021, 07:13 PM
CHESS ROBERT	Director	Jul 22, 2021	Sale	$16.80	91	1,529	280,573	Jul 22, 2021, 07:13 PM
CHESS ROBERT	Director	Jul 21, 2021	Sale	$16.81	3,524	59,238	280,573	Jul 22, 2021, 07:13 PM
CHESS ROBERT	Director	Jul 20, 2021	Sale	$16.80	2,106	35,381	280,573	Jul 22, 2021, 07:13 PM
Labrucherie Gil M	SVP, COO & CFO	May 17, 2021	Sale	$18.30	7,898	144,533	251,098	May 19, 2021, 07:04 PM
CHESS ROBERT	Director	May 12, 2021	Option Exercise	$13.80	8,000	110,400	288,573	May 14, 2021, 06:05 PM
CHESS ROBERT	Director	May 12, 2021	Sale	$19.34	8,000	154,720	280,573	May 14, 2021, 06:05 PM
CHESS ROBERT	Director	Apr 14, 2021	Option Exercise	$13.80	8,000	110,400	288,573	Apr 16, 2021, 06:02 PM
CHESS ROBERT	Director	Apr 14, 2021	Sale	$18.98	8,000	151,840	280,573	Apr 16, 2021, 06:02 PM
Zalevsky Jonathan	Chief R&D Officer	Feb 16, 2021	Sale	$22.37	24,141	540,034	266,176	Feb 18, 2021, 07:07 PM
Wilson Mark Andrew	SVP & General Counsel	Feb 16, 2021	Sale	$22.37	2,173	48,610	76,727	Feb 18, 2021, 07:06 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 16, 2021	Sale	$22.37	11,705	261,841	164,552	Feb 18, 2021, 07:05 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2021	Sale	$22.37	11,495	257,143	447,198	Feb 18, 2021, 07:04 PM
NORTHCOTT JOHN	SVP & Chief Commercial Officer	Feb 16, 2021	Sale	$22.37	15,358	343,558	213,192	Feb 18, 2021, 07:03 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 16, 2021	Sale	$22.37	7,977	178,445	258,996	Feb 18, 2021, 07:03 PM
Wilson Mark Andrew	SVP & General Counsel	Feb 03, 2021	Option Exercise	$8.80	5,344	47,027	84,244	Feb 04, 2021, 08:44 PM
Wilson Mark Andrew	SVP & General Counsel	Feb 03, 2021	Sale	$19.45	5,344	103,941	78,900	Feb 04, 2021, 08:44 PM
ROBIN HOWARD W	President & CEO	Feb 04, 2021	Option Exercise	$8.80	150,000	1,320,000	608,693	Feb 04, 2021, 08:43 PM
ROBIN HOWARD W	President & CEO	Feb 03, 2021	Option Exercise	$8.80	150,000	1,320,000	608,693	Feb 04, 2021, 08:43 PM
ROBIN HOWARD W	President & CEO	Feb 02, 2021	Option Exercise	$8.80	150,000	1,320,000	608,693	Feb 04, 2021, 08:43 PM
ROBIN HOWARD W	President & CEO	Feb 04, 2021	Sale	$20.29	150,000	3,042,906	516,830	Feb 04, 2021, 08:43 PM
ROBIN HOWARD W	President & CEO	Feb 03, 2021	Sale	$19.72	150,000	2,958,000	458,693	Feb 04, 2021, 08:43 PM
ROBIN HOWARD W	President & CEO	Feb 02, 2021	Sale	$19.77	150,000	2,966,025	469,193	Feb 04, 2021, 08:43 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 04, 2021	Option Exercise	$8.80	50,000	440,000	316,973	Feb 04, 2021, 08:42 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 03, 2021	Option Exercise	$8.80	50,000	440,000	316,973	Feb 04, 2021, 08:42 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 02, 2021	Option Exercise	$8.80	50,000	440,000	316,973	Feb 04, 2021, 08:42 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 04, 2021	Sale	$19.81	50,000	990,500	266,973	Feb 04, 2021, 08:42 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 03, 2021	Sale	$19.61	50,000	980,500	266,973	Feb 04, 2021, 08:42 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 02, 2021	Sale	$20.17	50,000	1,008,629	275,838	Feb 04, 2021, 08:42 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jan 28, 2021	Option Exercise	$8.80	75,000	660,000	251,257	Jan 29, 2021, 06:10 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jan 28, 2021	Sale	$18.62	75,000	1,396,500	176,257	Jan 29, 2021, 06:10 PM
GREER R SCOTT	Director	Jan 05, 2021	Option Exercise	$13.80	40,000	552,000	225,674	Jan 05, 2021, 05:09 PM
Myriam Curet	Director	Dec 15, 2020	Sale	$17.82	1,560	27,799	19,240	Dec 17, 2020, 06:08 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 23, 2020	Sale	$16.40	16,380	268,632	250,317	Nov 25, 2020, 06:09 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 16, 2020	Sale	$16.93	29,618	501,433	266,697	Nov 18, 2020, 07:08 PM
Wilson Mark Andrew	SVP & General Counsel	Nov 16, 2020	Sale	$16.93	1,539	26,055	49,850	Nov 18, 2020, 07:07 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 16, 2020	Sale	$16.93	11,976	202,754	159,757	Nov 18, 2020, 07:05 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2020	Sale	$16.93	11,975	202,737	352,043	Nov 18, 2020, 07:04 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 16, 2020	Sale	$16.93	8,276	140,113	226,973	Nov 18, 2020, 07:03 PM
Ajer Jeffrey Robert	Director	Sep 28, 2020	Sale	$17.25	3,250	56,063	25,975	Sep 30, 2020, 07:03 PM
CHESS ROBERT	Director	Sep 25, 2020	Sale	$17.75	5,500	97,625	280,573	Sep 25, 2020, 08:16 PM
Labrucherie Gil M	SVP, COO & CFO	Sep 17, 2020	Sale	$19.96	2,000	39,920	235,249	Sep 21, 2020, 08:59 PM
Ajer Jeffrey Robert	Director	Sep 21, 2020	Sale	$19.74	2,250	44,415	20,125	Sep 21, 2020, 08:58 PM
CHESS ROBERT	Director	Sep 08, 2020	Option Exercise	$9.24	8,000	73,920	284,973	Sep 10, 2020, 08:19 PM
CHESS ROBERT	Director	Sep 08, 2020	Sale	$18.53	8,000	148,240	276,973	Sep 10, 2020, 08:19 PM
WHITFIELD ROY A	Director	Sep 04, 2020	Option Exercise	$9.24	30,000	277,200	228,250	Sep 08, 2020, 06:18 PM
Zalevsky Jonathan	Chief R&D Officer	Aug 17, 2020	Sale	$19.67	26,200	515,354	296,315	Aug 19, 2020, 06:41 PM
Wilson Mark Andrew	SVP & General Counsel	Aug 17, 2020	Sale	$19.67	1,529	30,075	51,389	Aug 19, 2020, 06:40 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 17, 2020	Sale	$19.67	1,367	26,889	171,733	Aug 19, 2020, 06:39 PM
ROBIN HOWARD W	President & CEO	Aug 17, 2020	Sale	$19.67	11,885	233,778	364,018	Aug 19, 2020, 06:38 PM
Labrucherie Gil M	SVP, COO & CFO	Aug 18, 2020	Sale	$19.68	2,000	39,360	237,249	Aug 19, 2020, 06:37 PM
Labrucherie Gil M	SVP, COO & CFO	Aug 17, 2020	Sale	$19.67	6,245	122,839	239,249	Aug 19, 2020, 06:37 PM
GREER R SCOTT	Director	Jul 09, 2020	Option Exercise	$9.24	40,000	369,600	191,583	Jul 10, 2020, 07:06 PM
GREER R SCOTT	Director	Jul 09, 2020	Sale	$25.00	15,009	375,225	176,574	Jul 10, 2020, 07:06 PM
CHESS ROBERT	Director	Jul 08, 2020	Option Exercise	$9.24	8,000	73,920	284,973	Jul 10, 2020, 07:05 PM
CHESS ROBERT	Director	Jul 08, 2020	Sale	$24.58	8,000	196,640	276,973	Jul 10, 2020, 07:05 PM
Zalevsky Jonathan	Chief R&D Officer	May 18, 2020	Sale	$22.51	4,558	102,601	322,515	May 20, 2020, 06:33 PM
Wilson Mark Andrew	SVP & General Counsel	May 18, 2020	Sale	$22.51	1,529	34,418	52,418	May 20, 2020, 06:32 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 18, 2020	Sale	$22.51	1,367	30,771	172,719	May 20, 2020, 06:31 PM
ROBIN HOWARD W	President & CEO	May 18, 2020	Sale	$22.51	8,968	201,870	375,903	May 20, 2020, 06:30 PM
Labrucherie Gil M	SVP, COO & CFO	May 18, 2020	Sale	$22.51	5,727	128,915	247,494	May 20, 2020, 06:29 PM
Labrucherie Gil M	SVP, COO & CFO	May 19, 2020	Sale	$22.62	2,000	45,240	245,494	May 20, 2020, 06:29 PM
CHESS ROBERT	Director	Apr 15, 2020	Option Exercise	$9.24	8,000	73,920	284,973	Apr 17, 2020, 06:03 PM
CHESS ROBERT	Director	Apr 15, 2020	Sale	$18.38	8,000	147,010	277,170	Apr 17, 2020, 06:03 PM
CHESS ROBERT	Director	Mar 11, 2020	Option Exercise	$9.24	8,000	73,920	284,973	Mar 13, 2020, 06:04 PM
CHESS ROBERT	Director	Mar 11, 2020	Sale	$16.79	8,000	134,316	278,173	Mar 13, 2020, 06:04 PM
Zalevsky Jonathan	Chief R&D Officer	Feb 18, 2020	Sale	$22.35	4,774	106,699	327,073	Feb 20, 2020, 06:39 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 18, 2020	Sale	$22.35	1,394	31,156	174,086	Feb 20, 2020, 06:39 PM
ROBIN HOWARD W	President & CEO	Feb 18, 2020	Sale	$22.35	8,448	188,813	384,871	Feb 20, 2020, 06:38 PM
Labrucherie Gil M	SVP, COO & CFO	Feb 18, 2020	Sale	$22.35	5,938	132,714	253,221	Feb 20, 2020, 06:37 PM
CHESS ROBERT	Director	Feb 12, 2020	Option Exercise	$9.24	8,000	73,920	284,973	Feb 14, 2020, 07:00 PM
CHESS ROBERT	Director	Feb 12, 2020	Sale	$23.50	8,000	188,000	280,572	Feb 14, 2020, 07:00 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 06, 2020	Option Exercise	$7.21	37,500	270,375	212,980	Feb 07, 2020, 07:31 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 06, 2020	Sale	$22.78	37,500	854,250	175,480	Feb 07, 2020, 07:31 PM
WHITFIELD ROY A	Director	Dec 18, 2019	Option Exercise	$9.24	10,000	92,400	198,250	Dec 20, 2019, 06:31 PM
Zalevsky Jonathan	Chief R&D Officer	Nov 18, 2019	Sale	$17.97	3,960	71,161	291,697	Nov 20, 2019, 07:07 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 18, 2019	Sale	$17.97	2,713	48,753	160,441	Nov 20, 2019, 07:06 PM
ROBIN HOWARD W	President & CEO	Nov 18, 2019	Sale	$17.97	13,556	243,601	299,219	Nov 20, 2019, 07:05 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 18, 2019	Sale	$17.97	8,863	159,268	219,009	Nov 20, 2019, 07:04 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 13, 2019	Option Exercise	$7.21	25,000	180,250	252,872	Nov 15, 2019, 06:09 PM
Labrucherie Gil M	SVP, COO & CFO	Nov 13, 2019	Sale	$19.79	25,000	494,750	227,872	Nov 15, 2019, 06:09 PM
ROBIN HOWARD W	President & CEO	Oct 15, 2019	Option Exercise	$7.21	33,333	240,331	346,108	Oct 17, 2019, 07:00 PM
ROBIN HOWARD W	President & CEO	Oct 17, 2019	Option Exercise	$7.21	33,333	240,331	346,108	Oct 17, 2019, 07:00 PM
ROBIN HOWARD W	President & CEO	Oct 16, 2019	Option Exercise	$7.21	33,334	240,338	346,109	Oct 17, 2019, 07:00 PM
ROBIN HOWARD W	President & CEO	Oct 17, 2019	Sale	$17.68	33,333	589,327	312,775	Oct 17, 2019, 07:00 PM
ROBIN HOWARD W	President & CEO	Oct 16, 2019	Sale	$17.48	33,334	582,678	312,775	Oct 17, 2019, 07:00 PM
ROBIN HOWARD W	President & CEO	Oct 15, 2019	Sale	$16.95	33,333	565,085	337,275	Oct 17, 2019, 07:00 PM
Labrucherie Gil M	SVP, COO & CFO	Oct 15, 2019	Option Exercise	$7.21	25,000	180,250	252,872	Oct 17, 2019, 06:59 PM
Labrucherie Gil M	SVP, COO & CFO	Oct 15, 2019	Sale	$15.83	25,000	395,750	227,872	Oct 17, 2019, 06:59 PM
Lingnau Lutz	Director	Sep 27, 2019	Sale	$17.84	3,000	53,520	26,700	Oct 02, 2019, 07:51 PM
Ajer Jeffrey Robert	Director	Sep 30, 2019	Sale	$18.06	2,375	42,892	22,375	Oct 01, 2019, 07:16 PM
CHESS ROBERT	Director	Sep 27, 2019	Sale	$17.99	4,000	71,960	276,973	Oct 01, 2019, 07:15 PM
Ajer Jeffrey Robert	Director	Sep 20, 2019	Sale	$20.24	2,250	45,540	18,250	Sep 24, 2019, 06:07 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Sep 16, 2019	Option Exercise	$7.21	25,000	180,250	177,872	Sep 18, 2019, 07:07 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Sep 16, 2019	Sale	$20.52	25,000	513,000	152,872	Sep 18, 2019, 07:07 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Sep 05, 2019	Buy	$17.28	15,000	259,200	107,668	Sep 09, 2019, 05:09 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 26, 2019	Option Exercise	$16.31	30,000	489,300	152,872	Aug 27, 2019, 05:20 PM
ROBIN HOWARD W	President & CEO	Aug 23, 2019	Option Exercise	$16.31	30,000	489,300	312,775	Aug 26, 2019, 05:21 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2019	Sale	$18.15	1,809	32,833	163,154	Aug 19, 2019, 07:09 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2019	Sale	$18.15	12,551	227,801	282,775	Aug 19, 2019, 07:08 PM
Nicholson John	SVP & Chief Operating Officer	Aug 16, 2019	Sale	$18.15	3,819	69,315	162,759	Aug 19, 2019, 07:07 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 16, 2019	Sale	$18.15	5,063	91,893	122,872	Aug 19, 2019, 07:07 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Aug 16, 2019	Sale	$18.15	3,245	58,897	92,668	Aug 19, 2019, 07:06 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 14, 2019	Option Exercise	$7.21	25,000	180,250	152,935	Aug 16, 2019, 08:13 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 14, 2019	Sale	$17.79	25,000	444,750	127,935	Aug 16, 2019, 08:13 PM
ROBIN HOWARD W	President & CEO	Jul 24, 2019	Option Exercise	$7.21	33,334	240,338	328,660	Jul 25, 2019, 08:02 PM
ROBIN HOWARD W	President & CEO	Jul 23, 2019	Option Exercise	$7.21	33,333	240,331	328,659	Jul 25, 2019, 08:02 PM
ROBIN HOWARD W	President & CEO	Jul 25, 2019	Option Exercise	$7.21	33,333	240,331	328,659	Jul 25, 2019, 08:02 PM
ROBIN HOWARD W	President & CEO	Jul 24, 2019	Sale	$32.11	33,334	1,070,355	295,326	Jul 25, 2019, 08:02 PM
ROBIN HOWARD W	President & CEO	Jul 23, 2019	Sale	$32.10	33,333	1,069,989	295,326	Jul 25, 2019, 08:02 PM
ROBIN HOWARD W	President & CEO	Jul 25, 2019	Sale	$29.65	33,333	988,323	295,326	Jul 25, 2019, 08:02 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Jul 10, 2019	Option Exercise	$7.21	25,000	180,250	152,935	Jul 12, 2019, 06:31 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Jul 10, 2019	Sale	$34.57	25,000	864,250	127,935	Jul 12, 2019, 06:31 PM
Lingnau Lutz	Director	Jul 08, 2019	Option Exercise	$9.24	10,000	92,400	33,200	Jul 10, 2019, 05:34 PM
Lingnau Lutz	Director	Jul 08, 2019	Sale	$34.63	10,000	346,300	23,200	Jul 10, 2019, 05:34 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Jun 17, 2019	Option Exercise	$7.21	25,000	180,250	152,935	Jun 19, 2019, 05:50 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Jun 17, 2019	Sale	$33.71	25,000	842,750	127,935	Jun 19, 2019, 05:50 PM
ROBIN HOWARD W	President & CEO	May 22, 2019	Option Exercise	$7.21	33,334	240,338	328,660	May 23, 2019, 07:19 PM
ROBIN HOWARD W	President & CEO	May 21, 2019	Option Exercise	$7.21	33,333	240,331	328,659	May 23, 2019, 07:19 PM
ROBIN HOWARD W	President & CEO	May 23, 2019	Option Exercise	$7.21	33,333	240,331	328,659	May 23, 2019, 07:19 PM
ROBIN HOWARD W	President & CEO	May 21, 2019	Sale	$32.93	33,333	1,097,656	295,326	May 23, 2019, 07:19 PM
ROBIN HOWARD W	President & CEO	May 23, 2019	Sale	$32.69	33,333	1,089,656	295,326	May 23, 2019, 07:19 PM
ROBIN HOWARD W	President & CEO	May 22, 2019	Sale	$33.38	33,334	1,112,689	295,326	May 23, 2019, 07:19 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 16, 2019	Sale	$31.37	1,928	60,481	164,463	May 17, 2019, 08:22 PM
ROBIN HOWARD W	President & CEO	May 16, 2019	Sale	$31.37	13,383	419,825	295,326	May 17, 2019, 08:22 PM
Nicholson John	SVP & Chief Operating Officer	May 16, 2019	Sale	$31.37	4,077	127,895	166,578	May 17, 2019, 08:21 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 16, 2019	Sale	$31.37	3,767	118,171	127,935	May 17, 2019, 08:20 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	May 16, 2019	Sale	$31.37	2,449	76,825	94,694	May 17, 2019, 08:19 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	May 16, 2019	Sale	$31.37	3,461	108,572	95,913	May 17, 2019, 08:18 PM
GREER R SCOTT	Director	Mar 08, 2019	Option Exercise	$5.14	10,000	51,400	145,083	Mar 12, 2019, 06:18 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 19, 2019	Sale	$42.39	1,808	76,641	166,391	Feb 21, 2019, 08:17 PM
ROBIN HOWARD W	President & CEO	Feb 20, 2019	Option Exercise	$7.21	33,334	240,338	342,043	Feb 21, 2019, 08:16 PM
ROBIN HOWARD W	President & CEO	Feb 19, 2019	Option Exercise	$7.21	33,333	240,331	350,924	Feb 21, 2019, 08:16 PM
ROBIN HOWARD W	President & CEO	Feb 21, 2019	Option Exercise	$7.21	33,333	240,331	342,042	Feb 21, 2019, 08:16 PM
ROBIN HOWARD W	President & CEO	Feb 20, 2019	Sale	$43.20	33,334	1,440,029	308,709	Feb 21, 2019, 08:16 PM
ROBIN HOWARD W	President & CEO	Feb 19, 2019	Sale	$42.33	42,215	1,787,161	317,591	Feb 21, 2019, 08:16 PM
ROBIN HOWARD W	President & CEO	Feb 21, 2019	Sale	$41.01	33,333	1,366,986	308,709	Feb 21, 2019, 08:16 PM
Nicholson John	SVP & Chief Operating Officer	Feb 19, 2019	Sale	$42.39	3,822	162,015	170,655	Feb 21, 2019, 08:15 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Feb 19, 2019	Sale	$42.39	3,592	152,265	131,702	Feb 21, 2019, 08:14 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Feb 19, 2019	Sale	$42.39	2,386	101,143	97,143	Feb 21, 2019, 08:13 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Feb 19, 2019	Sale	$42.39	3,310	140,311	99,374	Feb 21, 2019, 08:13 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 04, 2019	Option Exercise	$10.69	16,119	172,312	184,318	Feb 06, 2019, 07:17 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 04, 2019	Sale	$42.16	16,119	679,577	168,199	Feb 06, 2019, 07:17 PM
Nicholson John	SVP & Chief Operating Officer	Jan 28, 2019	Option Exercise	$10.69	63,000	673,470	237,477	Jan 30, 2019, 06:02 PM
Nicholson John	SVP & Chief Operating Officer	Jan 28, 2019	Sale	$42.82	63,000	2,697,660	174,477	Jan 30, 2019, 06:02 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 16, 2018	Sale	$38.25	4,016	153,612	157,249	Nov 19, 2018, 06:15 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2018	Sale	$38.25	15,326	586,220	249,141	Nov 19, 2018, 06:14 PM
Nicholson John	SVP & Chief Operating Officer	Nov 16, 2018	Sale	$38.25	5,982	228,812	174,477	Nov 19, 2018, 06:14 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Nov 16, 2018	Sale	$38.25	6,515	249,199	106,544	Nov 19, 2018, 06:13 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 16, 2018	Sale	$38.25	4,694	179,546	81,029	Nov 19, 2018, 06:12 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 16, 2018	Sale	$38.25	4,524	173,043	78,734	Nov 19, 2018, 06:11 PM
Lingnau Lutz	Director	Sep 20, 2018	Sale	$56.98	9,000	512,820	18,450	Sep 21, 2018, 07:32 PM
CHESS ROBERT	Director	Sep 19, 2018	Sale	$56.81	4,500	255,645	269,723	Sep 21, 2018, 07:31 PM
Ajer Jeffrey Robert	Director	Sep 20, 2018	Sale	$56.76	6,750	383,130	15,750	Sep 21, 2018, 07:29 PM
GREER R SCOTT	Director	Sep 04, 2018	Option Exercise	$5.14	10,000	51,400	140,333	Sep 06, 2018, 07:12 PM
GREER R SCOTT	Director	Sep 04, 2018	Sale	$67.39	10,000	673,900	130,333	Sep 06, 2018, 07:12 PM
WINGER DENNIS L	Director	Aug 17, 2018	Option Exercise	$14.26	15,000	213,900	57,750	Aug 21, 2018, 07:32 PM
WINGER DENNIS L	Director	Aug 21, 2018	Option Exercise	$14.26	15,000	213,900	57,750	Aug 21, 2018, 07:32 PM
WINGER DENNIS L	Director	Aug 21, 2018	Sale	$60.30	15,000	904,500	42,750	Aug 21, 2018, 07:32 PM
WINGER DENNIS L	Director	Aug 17, 2018	Sale	$59.62	15,000	894,300	42,750	Aug 21, 2018, 07:32 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2018	Option Exercise	$58.40	4,883	285,167	71,265	Aug 16, 2018, 09:47 PM
Nicholson John	SVP & Chief Operating Officer	Aug 16, 2018	Option Exercise	$58.40	8,137	475,201	180,459	Aug 16, 2018, 09:46 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 16, 2018	Option Exercise	$58.40	8,207	479,289	113,059	Aug 16, 2018, 09:45 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Aug 16, 2018	Option Exercise	$58.40	5,946	347,246	85,723	Aug 16, 2018, 09:44 PM
ROBIN HOWARD W	President & CEO	Aug 14, 2018	Option Exercise	$10.69	40,000	427,600	264,356	Aug 16, 2018, 09:44 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2018	Option Exercise	$58.40	20,389	1,190,718	264,467	Aug 16, 2018, 09:44 PM
ROBIN HOWARD W	President & CEO	Aug 14, 2018	Option Exercise	$60.08	40,000	2,403,200	224,356	Aug 16, 2018, 09:44 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Aug 16, 2018	Option Exercise	$58.40	6,701	391,338	83,258	Aug 16, 2018, 09:43 PM
WINGER DENNIS L	Director	Aug 14, 2018	Sale	$60.15	17,125	1,030,069	42,750	Aug 15, 2018, 07:30 PM
WINGER DENNIS L	Director	Aug 13, 2018	Sale	$61.04	17,125	1,045,310	59,875	Aug 15, 2018, 07:30 PM
ROBIN HOWARD W	President & CEO	Jun 26, 2018	Option Exercise	$10.69	43,333	463,230	267,689	Jun 27, 2018, 07:42 PM
ROBIN HOWARD W	President & CEO	Jun 25, 2018	Option Exercise	$10.69	43,334	463,240	267,690	Jun 27, 2018, 07:42 PM
ROBIN HOWARD W	President & CEO	Jun 27, 2018	Option Exercise	$10.69	43,333	463,230	267,689	Jun 27, 2018, 07:42 PM
ROBIN HOWARD W	President & CEO	Jun 26, 2018	Sale	$49.36	43,333	2,138,917	224,356	Jun 27, 2018, 07:42 PM
ROBIN HOWARD W	President & CEO	Jun 25, 2018	Sale	$51.82	43,334	2,245,568	224,356	Jun 27, 2018, 07:42 PM
ROBIN HOWARD W	President & CEO	Jun 27, 2018	Sale	$47.39	43,333	2,053,551	224,356	Jun 27, 2018, 07:42 PM
WHITFIELD ROY A	Director	Jun 06, 2018	Buy	$59.37	3,400	201,860	177,000	Jun 07, 2018, 07:40 PM
WHITFIELD ROY A	Director	Jun 05, 2018	Buy	$55.22	1,600	88,352	173,600	Jun 07, 2018, 07:40 PM
CHESS ROBERT	Director	Jun 05, 2018	Option Exercise	$14.26	10,000	142,600	284,223	Jun 07, 2018, 07:39 PM
CHESS ROBERT	Director	Jun 05, 2018	Sale	$55.16	10,000	551,600	274,223	Jun 07, 2018, 07:39 PM
GREER R SCOTT	Director	Jun 06, 2018	Option Exercise	$5.14	8,600	44,204	138,933	Jun 06, 2018, 07:42 PM
GREER R SCOTT	Director	Jun 04, 2018	Option Exercise	$5.14	1,400	7,196	131,733	Jun 06, 2018, 07:42 PM
GREER R SCOTT	Director	Jun 06, 2018	Sale	$60.00	8,600	516,000	130,333	Jun 06, 2018, 07:42 PM
GREER R SCOTT	Director	Jun 04, 2018	Sale	$61.99	1,400	86,786	130,333	Jun 06, 2018, 07:42 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 16, 2018	Sale	$83.39	3,576	298,203	65,281	May 18, 2018, 07:07 PM
ROBIN HOWARD W	President & CEO	May 16, 2018	Sale	$83.39	12,791	1,066,641	224,356	May 18, 2018, 07:06 PM
Nicholson John	SVP & Chief Operating Officer	May 16, 2018	Sale	$83.39	4,917	410,029	162,596	May 18, 2018, 07:05 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 16, 2018	Sale	$83.39	4,941	412,030	94,798	May 18, 2018, 07:03 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	May 16, 2018	Sale	$83.39	4,060	338,563	76,201	May 18, 2018, 07:02 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	May 16, 2018	Sale	$83.39	3,435	286,445	63,959	May 18, 2018, 07:01 PM
CHESS ROBERT	Director	May 03, 2018	Option Exercise	$8.79	25,000	219,700	289,223	May 04, 2018, 06:55 PM
CHESS ROBERT	Director	May 03, 2018	Sale	$82.80	25,000	2,070,050	274,223	May 04, 2018, 06:55 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 03, 2018	Option Exercise	$10.69	30,000	320,700	129,739	May 03, 2018, 08:43 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 02, 2018	Option Exercise	$10.69	30,000	320,700	129,739	May 03, 2018, 08:43 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 01, 2018	Option Exercise	$10.69	30,000	320,700	129,739	May 03, 2018, 08:43 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 03, 2018	Sale	$82.86	30,000	2,485,800	99,739	May 03, 2018, 08:43 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 02, 2018	Sale	$85.63	30,000	2,568,900	99,739	May 03, 2018, 08:43 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 01, 2018	Sale	$83.65	30,000	2,509,500	99,739	May 03, 2018, 08:43 PM
ROBIN HOWARD W	President & CEO	May 03, 2018	Option Exercise	$10.69	43,333	463,230	280,480	May 03, 2018, 08:42 PM
ROBIN HOWARD W	President & CEO	May 02, 2018	Option Exercise	$10.69	43,333	463,230	280,480	May 03, 2018, 08:42 PM
ROBIN HOWARD W	President & CEO	May 01, 2018	Option Exercise	$10.69	43,334	463,240	280,481	May 03, 2018, 08:42 PM
ROBIN HOWARD W	President & CEO	May 03, 2018	Sale	$82.86	43,333	3,590,572	237,147	May 03, 2018, 08:42 PM
ROBIN HOWARD W	President & CEO	May 02, 2018	Sale	$85.63	43,333	3,710,605	237,147	May 03, 2018, 08:42 PM
ROBIN HOWARD W	President & CEO	May 01, 2018	Sale	$83.65	43,334	3,624,889	237,147	May 03, 2018, 08:42 PM
WHITFIELD ROY A	Director	Apr 17, 2018	Option Exercise	$14.26	30,000	427,800	172,000	Apr 18, 2018, 06:05 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Apr 16, 2018	Option Exercise	$10.69	13,881	148,388	82,738	Apr 18, 2018, 06:03 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Apr 16, 2018	Sale	$101.46	13,881	1,408,366	68,857	Apr 18, 2018, 06:03 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 10, 2018	Option Exercise	$7.21	502	3,619	80,763	Apr 12, 2018, 06:05 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 10, 2018	Sale	$105.67	502	53,046	80,261	Apr 12, 2018, 06:05 PM
Lingnau Lutz	Director	Apr 05, 2018	Option Exercise	$9.24	30,000	277,200	57,450	Apr 09, 2018, 08:23 PM
Lingnau Lutz	Director	Apr 05, 2018	Sale	$101.74	30,000	3,052,200	27,450	Apr 09, 2018, 08:23 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 09, 2018	Option Exercise	$7.21	9,498	68,481	89,759	Apr 09, 2018, 08:22 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 05, 2018	Option Exercise	$7.21	20,000	144,200	100,261	Apr 09, 2018, 08:22 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 09, 2018	Sale	$105.05	9,498	997,765	80,261	Apr 09, 2018, 08:22 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 05, 2018	Sale	$101.75	20,000	2,035,000	80,261	Apr 09, 2018, 08:22 PM
GREER R SCOTT	Director	Apr 06, 2018	Option Exercise	$14.26	30,000	427,800	160,333	Apr 09, 2018, 08:22 PM
GREER R SCOTT	Director	Apr 06, 2018	Sale	$92.22	30,000	2,766,600	130,333	Apr 09, 2018, 08:22 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 09, 2018	Option Exercise	$7.21	49,500	356,895	116,894	Apr 09, 2018, 08:21 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 06, 2018	Option Exercise	$9.10	110,500	1,005,505	177,894	Apr 09, 2018, 08:21 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 09, 2018	Sale	$96.13	49,500	4,758,435	67,394	Apr 09, 2018, 08:21 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 06, 2018	Sale	$91.69	110,500	10,131,745	67,394	Apr 09, 2018, 08:21 PM
CHESS ROBERT	Director	Apr 06, 2018	Option Exercise	$8.79	25,000	219,700	289,223	Apr 09, 2018, 08:20 PM
CHESS ROBERT	Director	Apr 06, 2018	Sale	$92.14	25,000	2,303,600	274,223	Apr 09, 2018, 08:20 PM
KUEBLER CHRISTOPHER A	Director	Mar 07, 2018	Option Exercise	$6.24	37,400	233,236	77,900	Mar 08, 2018, 06:10 PM
KUEBLER CHRISTOPHER A	Director	Mar 06, 2018	Option Exercise	$5.14	2,600	13,364	43,100	Mar 08, 2018, 06:10 PM
KUEBLER CHRISTOPHER A	Director	Mar 06, 2018	Sale	$100.30	2,600	260,780	40,500	Mar 08, 2018, 06:10 PM
KUEBLER CHRISTOPHER A	Director	Mar 07, 2018	Sale	$97.41	37,400	3,643,134	40,500	Mar 08, 2018, 06:10 PM
Nicholson John	SVP & Chief Operating Officer	Mar 07, 2018	Sale	$100.45	100,144	10,059,464	167,513	Mar 08, 2018, 06:09 PM
Nicholson John	SVP & Chief Operating Officer	Mar 06, 2018	Sale	$98.29	120,000	11,794,800	267,657	Mar 08, 2018, 06:09 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 16, 2018	Sale	$82.94	2,545	211,082	68,857	Feb 20, 2018, 07:10 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2018	Sale	$82.94	12,788	1,060,637	237,147	Feb 20, 2018, 07:10 PM
Nicholson John	SVP & Chief Operating Officer	Feb 16, 2018	Sale	$82.94	4,879	404,664	387,657	Feb 20, 2018, 07:09 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Feb 16, 2018	Sale	$82.94	3,477	288,382	99,739	Feb 20, 2018, 07:08 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Feb 16, 2018	Sale	$82.94	2,875	238,453	80,261	Feb 20, 2018, 07:07 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Feb 16, 2018	Sale	$82.94	2,426	201,212	67,394	Feb 20, 2018, 07:07 PM
Nicholson John	SVP & Chief Operating Officer	Jan 31, 2018	Option Exercise	$11.34	120,000	1,360,800	392,536	Feb 02, 2018, 06:03 PM
ROBIN HOWARD W	President & CEO	Jan 22, 2018	Option Exercise	$11.34	83,333	944,996	333,268	Jan 24, 2018, 06:01 PM
ROBIN HOWARD W	President & CEO	Jan 22, 2018	Sale	$75.82	83,333	6,318,308	249,935	Jan 24, 2018, 06:01 PM
WINGER DENNIS L	Director	Jan 04, 2018	Option Exercise	$11.97	33,750	403,988	77,000	Jan 08, 2018, 06:07 PM
KUEBLER CHRISTOPHER A	Director	Jan 02, 2018	Option Exercise	$14.26	30,000	427,800	70,500	Jan 04, 2018, 06:01 PM
KUEBLER CHRISTOPHER A	Director	Jan 02, 2018	Sale	$58.66	30,000	1,759,800	40,500	Jan 04, 2018, 06:01 PM
ROBIN HOWARD W	President & CEO	Dec 13, 2017	Option Exercise	$11.34	83,333	944,996	272,768	Dec 15, 2017, 06:00 PM
ROBIN HOWARD W	President & CEO	Dec 13, 2017	Sale	$55.69	83,333	4,640,815	189,435	Dec 15, 2017, 06:00 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 16, 2017	Option Exercise	$44.23	5,289	233,932	60,549	Nov 17, 2017, 06:06 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2017	Option Exercise	$44.23	18,069	799,192	189,435	Nov 17, 2017, 06:06 PM
Nicholson John	SVP & Chief Operating Officer	Nov 16, 2017	Option Exercise	$44.23	6,620	292,803	246,536	Nov 17, 2017, 06:05 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Nov 16, 2017	Option Exercise	$44.23	6,698	296,253	76,716	Nov 17, 2017, 06:05 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 16, 2017	Option Exercise	$44.23	5,597	247,555	67,636	Nov 17, 2017, 06:04 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Nov 16, 2017	Option Exercise	$44.23	5,022	222,123	56,553	Nov 17, 2017, 06:03 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 16, 2017	Option Exercise	$44.23	4,782	211,508	43,820	Nov 17, 2017, 06:03 PM
Nicholson John	SVP & Chief Operating Officer	Nov 13, 2017	Option Exercise	$9.24	25,000	231,000	249,066	Nov 15, 2017, 06:02 PM
Nicholson John	SVP & Chief Operating Officer	Nov 13, 2017	Sale	$37.78	15,910	601,080	233,156	Nov 15, 2017, 06:02 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 07, 2017	Option Exercise	$18.10	34,600	626,260	75,533	Nov 08, 2017, 06:02 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 06, 2017	Option Exercise	$10.69	5,117	54,701	63,350	Nov 08, 2017, 06:02 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 06, 2017	Sale	$25.07	5,117	128,283	58,233	Nov 08, 2017, 06:02 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 06, 2017	Option Exercise	$9.53	20,914	199,310	52,016	Nov 08, 2017, 06:01 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 08, 2017	Option Exercise	$9.53	300,000	2,859,000	331,102	Nov 08, 2017, 06:01 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 07, 2017	Option Exercise	$9.53	75,409	718,648	106,511	Nov 08, 2017, 06:01 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 06, 2017	Sale	$24.98	20,914	522,432	31,102	Nov 08, 2017, 06:01 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 08, 2017	Sale	$30.09	300,000	9,027,000	31,102	Nov 08, 2017, 06:01 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 07, 2017	Sale	$25.78	75,409	1,944,044	31,102	Nov 08, 2017, 06:01 PM
ROBIN HOWARD W	President & CEO	Nov 01, 2017	Option Exercise	$11.34	83,334	945,008	235,838	Nov 03, 2017, 06:07 PM
ROBIN HOWARD W	President & CEO	Nov 01, 2017	Sale	$23.57	83,334	1,964,182	152,504	Nov 03, 2017, 06:07 PM
ROBIN HOWARD W	President & CEO	Oct 09, 2017	Option Exercise	$11.34	83,333	944,996	235,837	Oct 10, 2017, 06:08 PM
ROBIN HOWARD W	President & CEO	Oct 09, 2017	Sale	$24.20	83,333	2,016,659	152,504	Oct 10, 2017, 06:08 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Oct 05, 2017	Option Exercise	$10.69	7,583	81,062	65,816	Oct 10, 2017, 06:07 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Oct 05, 2017	Sale	$25.00	7,583	189,575	58,233	Oct 10, 2017, 06:07 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Oct 05, 2017	Option Exercise	$9.53	43,677	416,242	74,779	Oct 10, 2017, 06:06 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Oct 05, 2017	Sale	$24.97	43,677	1,090,615	31,102	Oct 10, 2017, 06:06 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Oct 02, 2017	Option Exercise	$11.34	120,000	1,360,800	183,414	Oct 03, 2017, 06:06 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Oct 02, 2017	Sale	$24.45	120,000	2,934,000	63,414	Oct 03, 2017, 06:06 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Oct 02, 2017	Option Exercise	$11.04	56,704	626,012	98,279	Oct 03, 2017, 06:02 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Sep 29, 2017	Option Exercise	$11.04	43,296	477,988	84,871	Oct 03, 2017, 06:02 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Oct 02, 2017	Sale	$24.21	56,704	1,372,804	41,575	Oct 03, 2017, 06:02 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Sep 29, 2017	Sale	$24.04	43,296	1,040,836	41,575	Oct 03, 2017, 06:02 PM
Lingnau Lutz	Director	Sep 22, 2017	Sale	$21.97	5,000	109,850	27,450	Sep 25, 2017, 06:04 PM
KUEBLER CHRISTOPHER A	Director	Sep 22, 2017	Sale	$21.86	4,000	87,440	40,500	Sep 25, 2017, 06:03 PM
CHESS ROBERT	Director	Sep 21, 2017	Sale	$21.72	6,400	139,008	274,223	Sep 25, 2017, 06:02 PM
ROBIN HOWARD W	President & CEO	Sep 06, 2017	Option Exercise	$11.34	83,333	944,996	235,837	Sep 08, 2017, 06:08 PM
ROBIN HOWARD W	President & CEO	Sep 06, 2017	Sale	$21.54	83,333	1,794,993	152,504	Sep 08, 2017, 06:08 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2017	Sale	$19.32	2,648	51,159	50,838	Aug 18, 2017, 07:05 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2017	Option Exercise	$11.34	83,334	945,008	235,838	Aug 18, 2017, 07:05 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2017	Sale	$19.26	91,714	1,766,081	152,504	Aug 18, 2017, 07:05 PM
Nicholson John	SVP & Chief Operating Officer	Aug 16, 2017	Sale	$19.32	3,177	61,380	224,066	Aug 18, 2017, 07:04 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 16, 2017	Sale	$19.32	3,177	61,380	63,414	Aug 18, 2017, 07:04 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Aug 16, 2017	Sale	$19.32	2,956	57,110	58,233	Aug 18, 2017, 07:03 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Aug 16, 2017	Sale	$19.32	1,997	38,582	41,575	Aug 18, 2017, 07:02 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Aug 16, 2017	Sale	$19.32	1,701	32,863	31,102	Aug 18, 2017, 07:01 PM
WHITFIELD ROY A	Director	Aug 10, 2017	Buy	$17.95	35,000	628,250	133,000	Aug 14, 2017, 09:07 AM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 18, 2017	Option Exercise	$11.04	54,920	606,317	98,492	Jul 20, 2017, 05:08 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 18, 2017	Sale	$21.10	54,920	1,158,812	43,572	Jul 20, 2017, 05:08 PM
Lingnau Lutz	Director	Jul 14, 2017	Option Exercise	$14.26	30,000	427,800	53,450	Jul 18, 2017, 08:02 PM
Lingnau Lutz	Director	Jul 14, 2017	Sale	$20.76	30,000	622,800	23,450	Jul 18, 2017, 08:02 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 11, 2017	Option Exercise	$11.04	8,389	92,615	51,961	Jul 13, 2017, 08:01 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 12, 2017	Option Exercise	$11.04	36,691	405,069	80,263	Jul 13, 2017, 08:01 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 11, 2017	Sale	$21.04	8,389	176,505	43,572	Jul 13, 2017, 08:01 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Jul 12, 2017	Sale	$21.09	36,691	773,813	43,572	Jul 13, 2017, 08:01 PM
Krivulka Joseph J	Director	Jun 26, 2017	Option Exercise	$8.37	15,000	125,550	73,000	Jun 28, 2017, 06:05 PM
Nicholson John	SVP & Chief Operating Officer	Jun 07, 2017	Option Exercise	$6.34	150,000	951,000	328,943	Jun 09, 2017, 06:02 PM
Nicholson John	SVP & Chief Operating Officer	Jun 07, 2017	Sale	$19.24	101,700	1,956,708	227,243	Jun 09, 2017, 06:02 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 16, 2017	Sale	$19.55	2,651	51,827	52,986	May 18, 2017, 08:50 PM
ROBIN HOWARD W	President & CEO	May 16, 2017	Sale	$19.55	8,388	163,985	160,884	May 18, 2017, 08:50 PM
Nicholson John	SVP & Chief Operating Officer	May 16, 2017	Sale	$19.55	3,146	61,504	178,943	May 18, 2017, 08:49 PM
Labrucherie Gil M	SVP & Chief Financial Officer	May 16, 2017	Sale	$19.55	3,179	62,149	66,091	May 18, 2017, 08:48 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	May 16, 2017	Sale	$19.55	2,959	57,848	60,689	May 18, 2017, 08:47 PM
Gergel Ivan P.	SVP & Chief Medical Officer	May 16, 2017	Sale	$19.55	1,450	28,347	43,572	May 18, 2017, 08:46 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	May 16, 2017	Sale	$19.55	1,701	33,255	32,803	May 18, 2017, 08:45 PM
CHESS ROBERT	Director	May 15, 2017	Option Exercise	$8.37	5,000	41,850	276,623	May 17, 2017, 06:02 PM
CHESS ROBERT	Director	May 15, 2017	Sale	$19.79	5,000	98,950	271,623	May 17, 2017, 06:02 PM
CHESS ROBERT	Director	Apr 17, 2017	Option Exercise	$8.37	5,000	41,850	276,623	Apr 19, 2017, 07:30 PM
CHESS ROBERT	Director	Apr 17, 2017	Sale	$18.72	5,000	93,600	271,623	Apr 19, 2017, 07:30 PM
Lingnau Lutz	Director	Apr 07, 2017	Sale	$20.05	7,000	140,350	23,450	Apr 11, 2017, 06:04 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 05, 2017	Option Exercise	$9.53	100,000	953,000	134,504	Apr 07, 2017, 06:07 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Apr 05, 2017	Sale	$21.70	100,000	2,170,000	34,504	Apr 07, 2017, 06:07 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 05, 2017	Option Exercise	$13.70	180,000	2,466,000	243,648	Apr 07, 2017, 06:05 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Apr 05, 2017	Sale	$21.70	180,000	3,906,000	63,648	Apr 07, 2017, 06:05 PM
KUEBLER CHRISTOPHER A	Director	Apr 05, 2017	Option Exercise	$8.37	15,000	125,550	50,500	Apr 07, 2017, 06:01 PM
KUEBLER CHRISTOPHER A	Director	Apr 05, 2017	Sale	$21.88	15,000	328,200	35,500	Apr 07, 2017, 06:01 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Mar 20, 2017	Option Exercise	$9.96	112,500	1,120,875	168,137	Mar 22, 2017, 06:04 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Mar 20, 2017	Sale	$19.69	112,500	2,215,125	55,637	Mar 22, 2017, 06:04 PM
WHITFIELD ROY A	Director	Mar 15, 2017	Option Exercise	$8.37	14,000	117,180	98,000	Mar 17, 2017, 06:02 PM
CHESS ROBERT	Director	Mar 14, 2017	Option Exercise	$8.37	5,000	41,850	276,623	Mar 16, 2017, 06:02 PM
CHESS ROBERT	Director	Mar 14, 2017	Sale	$15.41	5,000	77,050	271,623	Mar 16, 2017, 06:02 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Mar 03, 2017	Option Exercise	$8.57	32,494	278,512	94,270	Mar 03, 2017, 07:04 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Mar 02, 2017	Option Exercise	$6.34	167,506	1,061,988	236,776	Mar 03, 2017, 07:04 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Mar 03, 2017	Sale	$15.21	32,494	494,234	69,270	Mar 03, 2017, 07:04 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Mar 02, 2017	Sale	$15.15	167,506	2,537,716	69,270	Mar 03, 2017, 07:04 PM
Lingnau Lutz	Director	Feb 21, 2017	Option Exercise	$5.14	30,000	154,200	60,450	Feb 23, 2017, 06:32 PM
Lingnau Lutz	Director	Feb 21, 2017	Sale	$13.08	30,000	392,400	30,450	Feb 23, 2017, 06:32 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 16, 2017	Sale	$13.14	1,965	25,820	55,637	Feb 17, 2017, 08:06 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2017	Sale	$13.14	8,636	113,477	169,272	Feb 17, 2017, 08:06 PM
Nicholson John	SVP & Chief Operating Officer	Feb 16, 2017	Sale	$13.14	3,237	42,534	182,089	Feb 17, 2017, 08:05 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Feb 16, 2017	Sale	$13.14	2,359	30,997	69,270	Feb 17, 2017, 08:04 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Feb 16, 2017	Sale	$13.14	2,195	28,842	63,648	Feb 17, 2017, 08:04 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Feb 16, 2017	Sale	$13.14	1,457	19,145	45,022	Feb 17, 2017, 08:03 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Feb 16, 2017	Sale	$13.14	1,261	16,570	34,504	Feb 17, 2017, 08:02 PM
Nicholson John	SVP & Chief Operating Officer	Feb 10, 2017	Option Exercise	$4.65	45,000	209,250	185,326	Feb 10, 2017, 08:11 PM
ROBIN HOWARD W	President & CEO	Feb 08, 2017	Option Exercise	$4.65	87,500	406,875	265,408	Feb 10, 2017, 08:10 PM
ROBIN HOWARD W	President & CEO	Feb 08, 2017	Sale	$13.04	87,500	1,141,000	177,908	Feb 10, 2017, 08:10 PM
Nicholson John	SVP & Chief Operating Officer	Feb 02, 2017	Option Exercise	$4.65	66,495	309,202	206,821	Feb 06, 2017, 05:20 PM
Nicholson John	SVP & Chief Operating Officer	Feb 03, 2017	Option Exercise	$4.65	8,505	39,548	148,831	Feb 06, 2017, 05:20 PM
Nicholson John	SVP & Chief Operating Officer	Feb 02, 2017	Sale	$12.38	66,495	823,208	140,326	Feb 06, 2017, 05:20 PM
Nicholson John	SVP & Chief Operating Officer	Feb 03, 2017	Sale	$12.48	8,505	106,142	140,326	Feb 06, 2017, 05:20 PM
ROBIN HOWARD W	President & CEO	Jan 17, 2017	Option Exercise	$4.65	87,500	406,875	265,408	Jan 19, 2017, 08:01 PM
ROBIN HOWARD W	President & CEO	Jan 17, 2017	Sale	$12.35	87,500	1,080,625	177,908	Jan 19, 2017, 08:01 PM
ROBIN HOWARD W	President & CEO	Dec 07, 2016	Option Exercise	$4.65	87,500	406,875	210,408	Dec 09, 2016, 06:03 PM
ROBIN HOWARD W	President & CEO	Dec 07, 2016	Sale	$12.24	87,500	1,071,000	122,908	Dec 09, 2016, 06:03 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 16, 2016	Sale	$13.96	1,986	27,725	42,102	Nov 18, 2016, 06:12 PM
ROBIN HOWARD W	President & CEO	Nov 17, 2016	Option Exercise	$4.65	87,500	406,875	210,408	Nov 18, 2016, 06:12 PM
ROBIN HOWARD W	President & CEO	Nov 17, 2016	Sale	$13.87	87,500	1,213,625	122,908	Nov 18, 2016, 06:12 PM
ROBIN HOWARD W	President & CEO	Nov 16, 2016	Sale	$13.96	5,958	83,174	122,908	Nov 18, 2016, 06:12 PM
Nicholson John	SVP & Chief Operating Officer	Nov 16, 2016	Sale	$13.96	1,654	23,090	120,326	Nov 18, 2016, 06:11 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Nov 16, 2016	Sale	$13.96	1,654	23,090	51,129	Nov 18, 2016, 06:10 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Nov 16, 2016	Sale	$13.96	1,654	23,090	50,343	Nov 18, 2016, 06:09 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Nov 16, 2016	Sale	$13.96	848	11,838	26,479	Nov 18, 2016, 06:08 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Nov 16, 2016	Sale	$13.96	670	9,353	18,265	Nov 18, 2016, 06:07 PM
GREER R SCOTT	Director	Oct 24, 2016	Buy	$13.50	15,000	202,500	121,333	Oct 25, 2016, 05:00 PM
ROBIN HOWARD W	President & CEO	Oct 04, 2016	Option Exercise	$4.65	87,500	406,875	216,366	Oct 06, 2016, 05:07 PM
ROBIN HOWARD W	President & CEO	Oct 04, 2016	Sale	$17.06	87,500	1,492,750	128,866	Oct 06, 2016, 05:07 PM
WHITFIELD ROY A	Director	Sep 23, 2016	Option Exercise	$5.21	46,000	239,820	84,000	Sep 27, 2016, 05:09 PM
Lingnau Lutz	Director	Sep 15, 2016	Sale	$19.06	9,000	171,540	7,450	Sep 19, 2016, 05:16 PM
KUEBLER CHRISTOPHER A	Director	Sep 16, 2016	Sale	$19.13	7,500	143,475	27,500	Sep 19, 2016, 05:15 PM
CHESS ROBERT	Director	Sep 15, 2016	Sale	$19.21	12,000	230,520	248,623	Sep 19, 2016, 05:13 PM
ROBIN HOWARD W	President & CEO	Sep 01, 2016	Option Exercise	$4.65	87,500	406,875	216,366	Sep 02, 2016, 08:03 PM
ROBIN HOWARD W	President & CEO	Sep 01, 2016	Sale	$17.83	87,500	1,560,125	128,886	Sep 02, 2016, 08:03 PM
Nicholson John	SVP & Chief Operating Officer	Aug 16, 2016	Sale	$17.56	3,317	58,247	121,980	Aug 17, 2016, 05:45 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Aug 16, 2016	Sale	$17.56	3,971	69,731	44,088	Aug 17, 2016, 05:42 PM
ROBIN HOWARD W	President & CEO	Aug 16, 2016	Sale	$17.56	11,817	207,507	128,866	Aug 17, 2016, 05:41 PM
Labrucherie Gil M	SVP & Chief Financial Officer	Aug 16, 2016	Sale	$17.56	3,305	58,036	52,783	Aug 17, 2016, 05:39 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Aug 16, 2016	Sale	$17.56	3,305	58,036	51,997	Aug 17, 2016, 05:38 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Aug 16, 2016	Sale	$17.56	1,685	29,589	27,327	Aug 17, 2016, 05:38 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Aug 16, 2016	Sale	$17.56	1,336	23,460	18,935	Aug 17, 2016, 05:37 PM
CHESS ROBERT	Director	Aug 01, 2016	Option Exercise	$5.15	5,000	25,750	265,623	Aug 03, 2016, 07:01 PM
CHESS ROBERT	Director	Aug 01, 2016	Sale	$17.26	5,000	86,300	260,623	Aug 03, 2016, 07:01 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jul 11, 2016	Option Exercise	$4.65	100,000	465,000	106,809	Jul 13, 2016, 05:08 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jul 11, 2016	Sale	$15.09	100,000	1,509,000	6,809	Jul 13, 2016, 05:08 PM
CHESS ROBERT	Director	Jul 01, 2016	Option Exercise	$5.15	5,000	25,750	265,623	Jul 05, 2016, 05:21 PM
CHESS ROBERT	Director	Jul 01, 2016	Sale	$14.10	5,000	70,500	260,623	Jul 05, 2016, 05:21 PM
CHESS ROBERT	Director	Jun 01, 2016	Option Exercise	$5.15	5,000	25,750	265,623	Jun 03, 2016, 05:05 PM
CHESS ROBERT	Director	Jun 01, 2016	Sale	$15.50	5,000	77,500	260,623	Jun 03, 2016, 05:05 PM
Nicholson John	SVP & Chief Financial Officer	May 16, 2016	Option Exercise	$0.00	2,167	0	78,486	May 18, 2016, 05:23 PM
Nicholson John	SVP & Chief Financial Officer	May 17, 2016	Sale	$13.58	856	11,624	77,630	May 18, 2016, 05:23 PM
ROBIN HOWARD W	President & CEO	May 16, 2016	Option Exercise	$0.00	5,625	1	19,103	May 18, 2016, 05:23 PM
ROBIN HOWARD W	President & CEO	May 17, 2016	Sale	$13.58	2,170	29,469	16,933	May 18, 2016, 05:23 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	May 16, 2016	Option Exercise	$0.00	875	0	1,360	May 18, 2016, 05:15 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	May 17, 2016	Sale	$13.58	339	4,604	1,021	May 18, 2016, 05:15 PM
Gergel Ivan P.	SVP & Chief Medical Officer	May 16, 2016	Option Exercise	$0.00	1,250	0	1,944	May 18, 2016, 05:14 PM
Gergel Ivan P.	SVP & Chief Medical Officer	May 17, 2016	Sale	$13.58	432	5,867	1,512	May 18, 2016, 05:14 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	May 16, 2016	Option Exercise	$0.00	2,167	0	7,970	May 18, 2016, 05:13 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	May 17, 2016	Sale	$13.58	835	11,339	7,135	May 18, 2016, 05:13 PM
Labrucherie Gil M	SVP & General Counsel	May 16, 2016	Option Exercise	$0.00	2,167	0	8,757	May 18, 2016, 05:12 PM
Labrucherie Gil M	SVP & General Counsel	May 17, 2016	Sale	$13.58	836	11,353	7,921	May 18, 2016, 05:12 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 16, 2016	Option Exercise	$0.00	1,875	0	7,033	May 18, 2016, 05:08 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	May 17, 2016	Sale	$13.58	724	9,832	6,309	May 18, 2016, 05:08 PM
Lingnau Lutz	Director	Apr 25, 2016	Option Exercise	$8.37	15,000	125,550	31,450	Apr 27, 2016, 05:08 PM
Lingnau Lutz	Director	Apr 25, 2016	Sale	$16.27	15,000	244,050	16,450	Apr 27, 2016, 05:08 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Mar 09, 2016	Option Exercise	$6.65	15,000	99,750	20,158	Mar 11, 2016, 05:06 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Mar 09, 2016	Sale	$11.79	15,000	176,850	5,158	Mar 11, 2016, 05:06 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Feb 16, 2016	Option Exercise	$0.00	1,250	0	1,250	Feb 18, 2016, 07:49 PM
Gergel Ivan P.	SVP & Chief Medical Officer	Feb 17, 2016	Sale	$11.92	556	6,628	694	Feb 18, 2016, 07:49 PM
Nicholson John	SVP & Chief Financial Officer	Feb 16, 2016	Option Exercise	$0.00	2,166	0	77,282	Feb 18, 2016, 07:48 PM
Nicholson John	SVP & Chief Financial Officer	Feb 17, 2016	Sale	$11.92	963	11,479	76,319	Feb 18, 2016, 07:48 PM
ROBIN HOWARD W	President & CEO	Feb 16, 2016	Option Exercise	$0.00	5,625	1	15,625	Feb 18, 2016, 07:48 PM
ROBIN HOWARD W	President & CEO	Feb 17, 2016	Sale	$11.92	2,147	25,592	13,478	Feb 18, 2016, 07:48 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Feb 16, 2016	Option Exercise	$0.00	875	0	875	Feb 18, 2016, 07:47 PM
Doberstein Stephen K	SVP & Chief Scientific Officer	Feb 17, 2016	Sale	$11.92	390	4,649	485	Feb 18, 2016, 07:47 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 16, 2016	Option Exercise	$0.00	1,875	0	5,874	Feb 18, 2016, 07:46 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 17, 2016	Sale	$11.92	716	8,535	5,158	Feb 18, 2016, 07:46 PM
Labrucherie Gil M	SVP & General Counsel	Feb 16, 2016	Option Exercise	$0.00	2,166	0	7,417	Feb 18, 2016, 07:45 PM
Labrucherie Gil M	SVP & General Counsel	Feb 17, 2016	Sale	$11.92	827	9,858	6,590	Feb 18, 2016, 07:45 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Feb 16, 2016	Option Exercise	$0.00	2,166	0	6,766	Feb 18, 2016, 07:45 PM
Hora Maninder	SVP Pharma Dev & Mfg Ops	Feb 17, 2016	Sale	$11.92	963	11,479	5,803	Feb 18, 2016, 07:45 PM
Labrucherie Gil M	SVP & General Counsel	Feb 10, 2016	Option Exercise	$6.46	11,666	75,362	16,917	Feb 12, 2016, 05:20 PM
Labrucherie Gil M	SVP & General Counsel	Feb 10, 2016	Sale	$11.49	11,666	134,042	5,251	Feb 12, 2016, 05:20 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 10, 2016	Option Exercise	$6.65	15,000	99,750	18,999	Feb 12, 2016, 05:19 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Feb 10, 2016	Sale	$11.49	15,000	172,350	3,999	Feb 12, 2016, 05:19 PM
ROBIN HOWARD W	President & CEO	Feb 10, 2016	Option Exercise	$6.46	66,666	430,662	76,666	Feb 12, 2016, 05:18 PM
ROBIN HOWARD W	President & CEO	Feb 10, 2016	Sale	$11.49	66,666	765,992	10,000	Feb 12, 2016, 05:18 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jan 19, 2016	Option Exercise	$6.65	15,000	99,750	18,999	Jan 21, 2016, 06:06 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Jan 19, 2016	Sale	$14.12	15,000	211,800	3,999	Jan 21, 2016, 06:06 PM
ROBIN HOWARD W	President & CEO	Jan 19, 2016	Option Exercise	$6.46	66,667	430,669	76,667	Jan 21, 2016, 06:05 PM
ROBIN HOWARD W	President & CEO	Jan 19, 2016	Sale	$14.12	66,667	941,338	10,000	Jan 21, 2016, 06:05 PM
Lingnau Lutz	Director	Jan 20, 2016	Option Exercise	$5.15	15,000	77,250	31,450	Jan 21, 2016, 06:04 PM
Lingnau Lutz	Director	Jan 20, 2016	Sale	$14.51	15,000	217,650	16,450	Jan 21, 2016, 06:04 PM
Labrucherie Gil M	SVP & General Counsel	Jan 19, 2016	Option Exercise	$6.46	11,667	75,369	16,918	Jan 21, 2016, 06:02 PM
Labrucherie Gil M	SVP & General Counsel	Jan 19, 2016	Sale	$14.12	11,667	164,738	5,251	Jan 21, 2016, 06:02 PM
Labrucherie Gil M	SVP & General Counsel	Dec 03, 2015	Option Exercise	$6.85	45,001	308,040	50,252	Dec 07, 2015, 05:36 PM
Labrucherie Gil M	SVP & General Counsel	Dec 03, 2015	Sale	$15.87	45,001	714,166	5,251	Dec 07, 2015, 05:36 PM
ROBIN HOWARD W	President & CEO	Dec 03, 2015	Option Exercise	$6.70	125,001	837,840	135,001	Dec 07, 2015, 05:33 PM
ROBIN HOWARD W	President & CEO	Dec 03, 2015	Sale	$15.87	125,001	1,983,766	10,000	Dec 07, 2015, 05:33 PM
KUEBLER CHRISTOPHER A	Director	Dec 04, 2015	Option Exercise	$5.15	15,000	77,250	35,000	Dec 07, 2015, 05:31 PM
KUEBLER CHRISTOPHER A	Director	Dec 04, 2015	Sale	$15.82	15,000	237,300	20,000	Dec 07, 2015, 05:31 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Dec 03, 2015	Option Exercise	$6.65	15,000	99,750	18,999	Dec 07, 2015, 05:29 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Dec 03, 2015	Sale	$15.87	15,000	238,050	3,999	Dec 07, 2015, 05:29 PM
WANG SUSAN	Director	Nov 18, 2015	Option Exercise	$7.52	20,372	153,162	35,000	Nov 20, 2015, 05:27 PM
WANG SUSAN	Director	Nov 20, 2015	Option Exercise	$8.45	49,500	418,430	60,000	Nov 20, 2015, 05:27 PM
WANG SUSAN	Director	Nov 19, 2015	Option Exercise	$5.14	15,128	77,758	35,128	Nov 20, 2015, 05:27 PM
WANG SUSAN	Director	Nov 18, 2015	Sale	$15.00	20,372	305,580	20,000	Nov 20, 2015, 05:27 PM
WANG SUSAN	Director	Nov 20, 2015	Sale	$15.02	49,500	743,490	20,000	Nov 20, 2015, 05:27 PM
WANG SUSAN	Director	Nov 19, 2015	Sale	$15.02	15,128	227,223	20,000	Nov 20, 2015, 05:27 PM
ROBIN HOWARD W	President & CEO	Nov 11, 2015	Option Exercise	$6.70	125,000	837,833	135,000	Nov 13, 2015, 05:41 PM
ROBIN HOWARD W	President & CEO	Nov 11, 2015	Sale	$13.52	125,000	1,690,000	10,000	Nov 13, 2015, 05:41 PM
Labrucherie Gil M	SVP & General Counsel	Nov 11, 2015	Option Exercise	$6.85	45,000	308,033	49,751	Nov 13, 2015, 05:35 PM
Labrucherie Gil M	SVP & General Counsel	Nov 11, 2015	Sale	$13.52	45,000	608,400	4,751	Nov 13, 2015, 05:35 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 11, 2015	Option Exercise	$6.65	15,000	99,750	18,499	Nov 13, 2015, 04:12 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Nov 11, 2015	Sale	$13.52	15,000	202,800	3,499	Nov 13, 2015, 04:12 PM
Lingnau Lutz	Director	Oct 28, 2015	Option Exercise	$6.65	12,500	83,125	28,950	Oct 30, 2015, 04:17 PM
Lingnau Lutz	Director	Oct 28, 2015	Sale	$12.00	12,500	150,000	16,450	Oct 30, 2015, 04:17 PM
GREER R SCOTT	Director	Oct 15, 2015	Option Exercise	$11.34	32,500	368,550	83,333	Oct 19, 2015, 05:01 PM
ROBIN HOWARD W	President & CEO	Oct 06, 2015	Option Exercise	$6.70	125,000	837,833	135,000	Oct 08, 2015, 07:12 PM
ROBIN HOWARD W	President & CEO	Oct 06, 2015	Sale	$10.99	125,000	1,373,750	10,000	Oct 08, 2015, 07:12 PM
Labrucherie Gil M	SVP & General Counsel	Oct 06, 2015	Option Exercise	$6.85	45,000	308,033	49,751	Oct 08, 2015, 07:11 PM
Labrucherie Gil M	SVP & General Counsel	Oct 06, 2015	Sale	$10.99	45,000	494,550	4,751	Oct 08, 2015, 07:11 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Oct 06, 2015	Option Exercise	$6.65	15,000	99,750	18,499	Oct 08, 2015, 07:09 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Oct 06, 2015	Sale	$10.99	15,000	164,850	3,499	Oct 08, 2015, 07:09 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Sep 23, 2015	Option Exercise	$6.65	10,000	66,500	13,499	Sep 25, 2015, 05:25 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Sep 23, 2015	Sale	$13.04	10,000	130,400	3,499	Sep 25, 2015, 05:25 PM
ROBIN HOWARD W	President & CEO	Sep 23, 2015	Option Exercise	$6.70	124,999	837,827	134,999	Sep 25, 2015, 05:24 PM
ROBIN HOWARD W	President & CEO	Sep 23, 2015	Sale	$13.04	124,999	1,629,987	10,000	Sep 25, 2015, 05:24 PM
Labrucherie Gil M	SVP & General Counsel	Sep 23, 2015	Option Exercise	$6.85	44,999	308,027	49,750	Sep 25, 2015, 05:22 PM
Labrucherie Gil M	SVP & General Counsel	Sep 23, 2015	Sale	$13.04	44,999	586,787	4,751	Sep 25, 2015, 05:22 PM
WHITFIELD ROY A	Director	Sep 11, 2015	Option Exercise	$8.81	15,000	132,150	15,000	Sep 15, 2015, 04:12 PM
Labrucherie Gil M	SVP & General Counsel	Aug 13, 2015	Option Exercise	$6.98	33,333	232,664	38,084	Aug 17, 2015, 04:04 PM
Labrucherie Gil M	SVP & General Counsel	Aug 13, 2015	Sale	$10.89	33,333	362,996	4,751	Aug 17, 2015, 04:04 PM
ROBIN HOWARD W	President & CEO	Aug 13, 2015	Option Exercise	$6.98	58,333	407,164	68,333	Aug 17, 2015, 04:03 PM
ROBIN HOWARD W	President & CEO	Aug 13, 2015	Sale	$10.89	58,333	635,246	10,000	Aug 17, 2015, 04:03 PM
Nicholson John	SVP & Chief Financial Officer	Aug 12, 2015	Option Exercise	$6.49	90,000	584,000	141,116	Aug 13, 2015, 05:10 PM
Nicholson John	SVP & Chief Financial Officer	Aug 11, 2015	Option Exercise	$8.26	295,000	2,437,100	164,908	Aug 13, 2015, 05:10 PM
Nicholson John	SVP & Chief Financial Officer	Aug 11, 2015	Sale	$10.87	249,908	2,716,089	10,000	Aug 13, 2015, 05:10 PM
Nicholson John	SVP & Chief Financial Officer	Aug 12, 2015	Sale	$10.48	69,976	733,325	75,116	Aug 13, 2015, 05:10 PM
Krivulka Joseph J	Director	Jul 24, 2015	Option Exercise	$8.81	15,000	132,150	35,000	Jul 28, 2015, 04:06 PM
ROBIN HOWARD W	President & CEO	Jul 14, 2015	Option Exercise	$6.98	58,334	407,171	68,334	Jul 16, 2015, 04:16 PM
ROBIN HOWARD W	President & CEO	Jul 14, 2015	Sale	$11.78	58,334	687,175	10,000	Jul 16, 2015, 04:16 PM
Labrucherie Gil M	SVP & General Counsel	Jul 14, 2015	Option Exercise	$6.98	33,334	232,671	37,585	Jul 16, 2015, 04:14 PM
Labrucherie Gil M	SVP & General Counsel	Jul 14, 2015	Sale	$11.78	33,334	392,675	4,251	Jul 16, 2015, 04:14 PM
WANG SUSAN	Director	Jun 29, 2015	Option Exercise	$6.98	30,000	209,400	35,000	Jul 01, 2015, 04:09 PM
WANG SUSAN	Director	Jun 29, 2015	Sale	$12.70	30,000	381,000	20,000	Jul 01, 2015, 04:09 PM
CHESS ROBERT	Director	Jun 19, 2015	Option Exercise	$8.81	15,000	132,150	275,623	Jun 23, 2015, 04:05 PM
CHESS ROBERT	Director	Jun 19, 2015	Sale	$11.81	15,000	177,150	260,623	Jun 23, 2015, 04:05 PM
Lingnau Lutz	Director	Jun 15, 2015	Option Exercise	$6.65	25,000	166,250	41,450	Jun 17, 2015, 04:07 PM
Lingnau Lutz	Director	Jun 15, 2015	Sale	$11.15	25,000	278,750	16,450	Jun 17, 2015, 04:07 PM
KUEBLER CHRISTOPHER A	Director	Jan 13, 2015	Option Exercise	$8.81	15,000	132,150	35,000	Jan 15, 2015, 05:54 PM
KUEBLER CHRISTOPHER A	Director	Jan 13, 2015	Sale	$16.00	15,000	240,000	20,000	Jan 15, 2015, 05:54 PM
CHESS ROBERT	Director	Dec 29, 2014	Option Exercise	$15.24	29,500	449,580	290,123	Dec 31, 2014, 05:37 PM
CHESS ROBERT	Director	Dec 29, 2014	Sale	$15.34	29,500	452,530	260,623	Dec 31, 2014, 05:37 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Dec 22, 2014	Option Exercise	$11.38	5,000	56,900	7,999	Dec 24, 2014, 04:09 PM
Thomsen Jillian B.	SVP & Chief Accounting Officer	Dec 22, 2014	Sale	$15.56	5,000	77,800	2,999	Dec 24, 2014, 04:09 PM
Labrucherie Gil M	SVP & General Counsel	Dec 01, 2014	Option Exercise	$4.65	30,000	139,500	34,251	Dec 02, 2014, 07:23 PM
Labrucherie Gil M	SVP & General Counsel	Nov 28, 2014	Option Exercise	$4.65	90,000	418,500	94,251	Dec 02, 2014, 07:23 PM
Labrucherie Gil M	SVP & General Counsel	Dec 01, 2014	Sale	$17.00	30,000	510,000	4,251	Dec 02, 2014, 07:23 PM
Labrucherie Gil M	SVP & General Counsel	Nov 28, 2014	Sale	$17.02	90,000	1,531,800	4,251	Dec 02, 2014, 07:23 PM
ROBIN HOWARD W	President & CEO	Dec 01, 2014	Option Exercise	$6.98	209,056	1,459,211	219,056	Dec 02, 2014, 07:22 PM
ROBIN HOWARD W	President & CEO	Nov 28, 2014	Option Exercise	$6.98	140,944	983,789	150,944	Dec 02, 2014, 07:22 PM
ROBIN HOWARD W	President & CEO	Nov 28, 2014	Sale	$17.02	140,944	2,398,867	10,000	Dec 02, 2014, 07:22 PM
ROBIN HOWARD W	President & CEO	Dec 01, 2014	Sale	$17.00	209,056	3,553,952	10,000	Dec 02, 2014, 07:22 PM
Labrucherie Gil M	SVP & General Counsel	Nov 24, 2014	Option Exercise	$13.02	10,500	136,710	14,251	Nov 26, 2014, 05:47 PM
Labrucherie Gil M	SVP & General Counsel	Nov 24, 2014	Sale	$15.04	10,500	157,920	3,751	Nov 26, 2014, 05:47 PM
ROBIN HOWARD W	President & CEO	Nov 25, 2014	Option Exercise	$14.52	467,200	6,783,744	477,200	Nov 26, 2014, 05:41 PM
ROBIN HOWARD W	President & CEO	Nov 24, 2014	Option Exercise	$14.52	132,800	1,928,256	142,800	Nov 26, 2014, 05:41 PM
ROBIN HOWARD W	President & CEO	Nov 24, 2014	Sale	$15.02	132,800	1,994,656	10,000	Nov 26, 2014, 05:41 PM
ROBIN HOWARD W	President & CEO	Nov 25, 2014	Sale	$15.31	467,200	7,152,832	10,000	Nov 26, 2014, 05:41 PM
Lingnau Lutz	Director	Nov 24, 2014	Option Exercise	$8.81	15,000	132,150	31,450	Nov 26, 2014, 05:39 PM
Lingnau Lutz	Director	Nov 24, 2014	Sale	$15.02	15,000	225,300	16,450	Nov 26, 2014, 05:39 PM
Labrucherie Gil M	SVP & General Counsel	Nov 03, 2014	Option Exercise	$11.38	9,900	112,662	13,651	Nov 04, 2014, 01:41 PM
Labrucherie Gil M	SVP & General Counsel	Nov 03, 2014	Sale	$13.78	9,900	136,422	3,751	Nov 04, 2014, 01:41 PM
KUEBLER CHRISTOPHER A	Director	Aug 05, 2013	Option Exercise	$11.41	12,500	142,625	32,500	Aug 08, 2013, 05:14 PM
KUEBLER CHRISTOPHER A	Director	Aug 05, 2013	Sale	$12.41	12,500	155,125	20,000	Aug 08, 2013, 05:14 PM
WHITFIELD ROY A	Director	Aug 05, 2013	Option Exercise	$11.41	12,500	142,625	32,500	Aug 07, 2013, 04:30 PM
WHITFIELD ROY A	Director	Aug 05, 2013	Sale	$12.41	12,500	155,125	20,000	Aug 07, 2013, 04:30 PM
KUEBLER CHRISTOPHER A	Director	Sep 27, 2012	Option Exercise	$8.66	12,500	108,250	32,500	Oct 01, 2012, 04:02 PM
KUEBLER CHRISTOPHER A	Director	Sep 27, 2012	Sale	$10.66	12,500	133,250	20,000	Oct 01, 2012, 04:02 PM
WINGER DENNIS L	Director	Sep 14, 2012	Buy	$9.18	5,000	45,908	5,000	Sep 18, 2012, 02:34 PM
CHESS ROBERT	Director	Jul 13, 2012	Option Exercise	$6.12	24,001	146,886	284,624	Jul 17, 2012, 04:10 PM
CHESS ROBERT	Director	Jul 13, 2012	Sale	$8.50	24,001	204,009	260,623	Jul 17, 2012, 04:10 PM
CHESS ROBERT	Director	Mar 08, 2011	Sale	$9.00	4,500	40,500	255,709	Mar 09, 2011, 12:14 PM

Load More Insider Transactions

Buy Sale Option Exercise

Owner	Relationship	Date	Value($)
Zalevsky Jonathan	Chief R&D Officer	02/20/2024	6,130
Wilson Mark Andrew	Chief Legal Officer	02/20/2024	5,172
ROBIN HOWARD W	President & CEO	02/20/2024	13,622
Zalevsky Jonathan	Chief R&D Officer	11/17/2023	4,727
Wilson Mark Andrew	Chief Legal Officer	11/17/2023	3,518
ROBIN HOWARD W	President & CEO	11/17/2023	9,740
Curet Myriam	Director	09/18/2023	3,008
CHESS ROBERT	Director	09/22/2022	6,834
Ajer Jeffrey Robert	Director	09/18/2023	3,008
Zalevsky Jonathan	Chief R&D Officer	08/16/2023	7,568
Wilson Mark Andrew	Chief Legal Officer	08/16/2023	5,632
ROBIN HOWARD W	President & CEO	08/16/2023	15,598
WHITFIELD ROY A	Director	06/14/2023	17,100
Zalevsky Jonathan	Chief R&D Officer	05/16/2023	7,050
Wilson Mark Andrew	Chief Legal Officer	05/16/2023	5,431
ROBIN HOWARD W	President & CEO	05/16/2023	14,660
Zalevsky Jonathan	Chief R&D Officer	02/16/2023	31,452
Wilson Mark Andrew	Chief Legal Officer	02/16/2023	24,825
Thomsen Jillian B.	Chief Financial Officer	02/16/2023	30,801
ROBIN HOWARD W	President & CEO	02/16/2023	58,905
Zalevsky Jonathan	Chief R&D Officer	11/16/2022	48,052
Wilson Mark Andrew	Chief Legal Officer	11/16/2022	31,023
Thomsen Jillian B.	Chief Financial Officer	11/16/2022	39,609
ROBIN HOWARD W	President & CEO	11/16/2022	135,710
Curet Myriam	Director	09/23/2022	13,266
Ajer Jeffrey Robert	Director	09/23/2022	13,266
CHESS ROBERT	Director	09/22/2022	16,269
EASTHAM KARIN	Director	09/13/2022	76,774
Zalevsky Jonathan	Chief R&D Officer	08/18/2022	342,779
Zalevsky Jonathan	Chief R&D Officer	08/16/2022	50,266
Wilson Mark Andrew	SVP & General Counsel	08/16/2022	15,180
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2022	9,549
ROBIN HOWARD W	President & CEO	08/16/2022	65,493
Zalevsky Jonathan	Chief R&D Officer	05/16/2022	85,608
Wilson Mark Andrew	SVP & General Counsel	05/16/2022	12,387
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/16/2022	23,072
ROBIN HOWARD W	President & CEO	05/16/2022	144,290
NORTHCOTT JOHN	SVP & Chief Commercial Officer	05/16/2022	18,138
Labrucherie Gil M	SVP, COO & CFO	05/16/2022	68,920
Zalevsky Jonathan	Chief R&D Officer	02/16/2022	119,486
Wilson Mark Andrew	SVP & General Counsel	02/16/2022	40,088
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/16/2022	25,875
ROBIN HOWARD W	President & CEO	02/16/2022	136,656
NORTHCOTT JOHN	SVP & Chief Commercial Officer	02/16/2022	53,129
Labrucherie Gil M	SVP, COO & CFO	02/16/2022	82,990
Labrucherie Gil M	SVP, COO & CFO	11/18/2021	38,070
Labrucherie Gil M	SVP, COO & CFO	11/16/2021	278,321
Zalevsky Jonathan	Chief R&D Officer	11/16/2021	274,636
Wilson Mark Andrew	SVP & General Counsel	11/16/2021	86,382
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/16/2021	88,712
ROBIN HOWARD W	President & CEO	11/16/2021	562,893
NORTHCOTT JOHN	SVP & Chief Commercial Officer	11/16/2021	79,763
GREER R SCOTT	Director	11/09/2021	160,000
Curet Myriam	Director	09/22/2021	65,164
CHESS ROBERT	Director	09/22/2021	82,524
Ajer Jeffrey Robert	Director	09/22/2021	65,164
WHITFIELD ROY A	Director	09/16/2021	552,000
CHESS ROBERT	Director	09/09/2021	141,850
CHESS ROBERT	Director	09/08/2021	110,400
CHESS ROBERT	Director	09/09/2021	164,670
CHESS ROBERT	Director	09/08/2021	128,000
GREER R SCOTT	Director	08/31/2021	571,500
Zalevsky Jonathan	Chief R&D Officer	08/16/2021	105,965
Wilson Mark Andrew	SVP & General Counsel	08/16/2021	26,415
ROBIN HOWARD W	President & CEO	08/16/2021	159,252
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2021	184,478
NORTHCOTT JOHN	SVP & Chief Commercial Officer	08/16/2021	85,635
Labrucherie Gil M	SVP, COO & CFO	08/17/2021	40,680
Labrucherie Gil M	SVP, COO & CFO	08/16/2021	108,801
CHESS ROBERT	Director	07/22/2021	1,256
CHESS ROBERT	Director	07/21/2021	48,631
CHESS ROBERT	Director	07/20/2021	29,063
CHESS ROBERT	Director	07/22/2021	1,529
CHESS ROBERT	Director	07/21/2021	59,238
CHESS ROBERT	Director	07/20/2021	35,381
Labrucherie Gil M	SVP, COO & CFO	05/17/2021	144,533
CHESS ROBERT	Director	05/12/2021	110,400
CHESS ROBERT	Director	05/12/2021	154,720
CHESS ROBERT	Director	04/14/2021	110,400
CHESS ROBERT	Director	04/14/2021	151,840
Zalevsky Jonathan	Chief R&D Officer	02/16/2021	540,034
Wilson Mark Andrew	SVP & General Counsel	02/16/2021	48,610
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/16/2021	261,841
ROBIN HOWARD W	President & CEO	02/16/2021	257,143
NORTHCOTT JOHN	SVP & Chief Commercial Officer	02/16/2021	343,558
Labrucherie Gil M	SVP, COO & CFO	02/16/2021	178,445
Wilson Mark Andrew	SVP & General Counsel	02/03/2021	47,027
Wilson Mark Andrew	SVP & General Counsel	02/03/2021	103,941
ROBIN HOWARD W	President & CEO	02/04/2021	1,320,000
ROBIN HOWARD W	President & CEO	02/03/2021	1,320,000
ROBIN HOWARD W	President & CEO	02/02/2021	1,320,000
ROBIN HOWARD W	President & CEO	02/04/2021	3,042,906
ROBIN HOWARD W	President & CEO	02/03/2021	2,958,000
ROBIN HOWARD W	President & CEO	02/02/2021	2,966,025
Labrucherie Gil M	SVP, COO & CFO	02/04/2021	440,000
Labrucherie Gil M	SVP, COO & CFO	02/03/2021	440,000
Labrucherie Gil M	SVP, COO & CFO	02/02/2021	440,000
Labrucherie Gil M	SVP, COO & CFO	02/04/2021	990,500
Labrucherie Gil M	SVP, COO & CFO	02/03/2021	980,500
Labrucherie Gil M	SVP, COO & CFO	02/02/2021	1,008,629
Thomsen Jillian B.	SVP & Chief Accounting Officer	01/28/2021	660,000
Thomsen Jillian B.	SVP & Chief Accounting Officer	01/28/2021	1,396,500
GREER R SCOTT	Director	01/05/2021	552,000
Myriam Curet	Director	12/15/2020	27,799
Zalevsky Jonathan	Chief R&D Officer	11/23/2020	268,632
Zalevsky Jonathan	Chief R&D Officer	11/16/2020	501,433
Wilson Mark Andrew	SVP & General Counsel	11/16/2020	26,055
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/16/2020	202,754
ROBIN HOWARD W	President & CEO	11/16/2020	202,737
Labrucherie Gil M	SVP, COO & CFO	11/16/2020	140,113
Ajer Jeffrey Robert	Director	09/28/2020	56,063
CHESS ROBERT	Director	09/25/2020	97,625
Labrucherie Gil M	SVP, COO & CFO	09/17/2020	39,920
Ajer Jeffrey Robert	Director	09/21/2020	44,415
CHESS ROBERT	Director	09/08/2020	73,920
CHESS ROBERT	Director	09/08/2020	148,240
WHITFIELD ROY A	Director	09/04/2020	277,200
Zalevsky Jonathan	Chief R&D Officer	08/17/2020	515,354
Wilson Mark Andrew	SVP & General Counsel	08/17/2020	30,075
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/17/2020	26,889
ROBIN HOWARD W	President & CEO	08/17/2020	233,778
Labrucherie Gil M	SVP, COO & CFO	08/18/2020	39,360
Labrucherie Gil M	SVP, COO & CFO	08/17/2020	122,839
GREER R SCOTT	Director	07/09/2020	369,600
GREER R SCOTT	Director	07/09/2020	375,225
CHESS ROBERT	Director	07/08/2020	73,920
CHESS ROBERT	Director	07/08/2020	196,640
Zalevsky Jonathan	Chief R&D Officer	05/18/2020	102,601
Wilson Mark Andrew	SVP & General Counsel	05/18/2020	34,418
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/18/2020	30,771
ROBIN HOWARD W	President & CEO	05/18/2020	201,870
Labrucherie Gil M	SVP, COO & CFO	05/18/2020	128,915
Labrucherie Gil M	SVP, COO & CFO	05/19/2020	45,240
CHESS ROBERT	Director	04/15/2020	73,920
CHESS ROBERT	Director	04/15/2020	147,010
CHESS ROBERT	Director	03/11/2020	73,920
CHESS ROBERT	Director	03/11/2020	134,316
Zalevsky Jonathan	Chief R&D Officer	02/18/2020	106,699
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/18/2020	31,156
ROBIN HOWARD W	President & CEO	02/18/2020	188,813
Labrucherie Gil M	SVP, COO & CFO	02/18/2020	132,714
CHESS ROBERT	Director	02/12/2020	73,920
CHESS ROBERT	Director	02/12/2020	188,000
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/06/2020	270,375
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/06/2020	854,250
WHITFIELD ROY A	Director	12/18/2019	92,400
Zalevsky Jonathan	Chief R&D Officer	11/18/2019	71,161
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/18/2019	48,753
ROBIN HOWARD W	President & CEO	11/18/2019	243,601
Labrucherie Gil M	SVP, COO & CFO	11/18/2019	159,268
Labrucherie Gil M	SVP, COO & CFO	11/13/2019	180,250
Labrucherie Gil M	SVP, COO & CFO	11/13/2019	494,750
ROBIN HOWARD W	President & CEO	10/15/2019	240,331
ROBIN HOWARD W	President & CEO	10/17/2019	240,331
ROBIN HOWARD W	President & CEO	10/16/2019	240,338
ROBIN HOWARD W	President & CEO	10/17/2019	589,327
ROBIN HOWARD W	President & CEO	10/16/2019	582,678
ROBIN HOWARD W	President & CEO	10/15/2019	565,085
Labrucherie Gil M	SVP, COO & CFO	10/15/2019	180,250
Labrucherie Gil M	SVP, COO & CFO	10/15/2019	395,750
Lingnau Lutz	Director	09/27/2019	53,520
Ajer Jeffrey Robert	Director	09/30/2019	42,892
CHESS ROBERT	Director	09/27/2019	71,960
Ajer Jeffrey Robert	Director	09/20/2019	45,540
Labrucherie Gil M	SVP & Chief Financial Officer	09/16/2019	180,250
Labrucherie Gil M	SVP & Chief Financial Officer	09/16/2019	513,000
Doberstein Stephen K	SVP & Chief Scientific Officer	09/05/2019	259,200
Labrucherie Gil M	SVP & Chief Financial Officer	08/26/2019	489,300
ROBIN HOWARD W	President & CEO	08/23/2019	489,300
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2019	32,833
ROBIN HOWARD W	President & CEO	08/16/2019	227,801
Nicholson John	SVP & Chief Operating Officer	08/16/2019	69,315
Labrucherie Gil M	SVP & Chief Financial Officer	08/16/2019	91,893
Doberstein Stephen K	SVP & Chief Scientific Officer	08/16/2019	58,897
Labrucherie Gil M	SVP & Chief Financial Officer	08/14/2019	180,250
Labrucherie Gil M	SVP & Chief Financial Officer	08/14/2019	444,750
ROBIN HOWARD W	President & CEO	07/24/2019	240,338
ROBIN HOWARD W	President & CEO	07/23/2019	240,331
ROBIN HOWARD W	President & CEO	07/25/2019	240,331
ROBIN HOWARD W	President & CEO	07/24/2019	1,070,355
ROBIN HOWARD W	President & CEO	07/23/2019	1,069,989
ROBIN HOWARD W	President & CEO	07/25/2019	988,323
Labrucherie Gil M	SVP & Chief Financial Officer	07/10/2019	180,250
Labrucherie Gil M	SVP & Chief Financial Officer	07/10/2019	864,250
Lingnau Lutz	Director	07/08/2019	92,400
Lingnau Lutz	Director	07/08/2019	346,300
Labrucherie Gil M	SVP & Chief Financial Officer	06/17/2019	180,250
Labrucherie Gil M	SVP & Chief Financial Officer	06/17/2019	842,750
ROBIN HOWARD W	President & CEO	05/22/2019	240,338
ROBIN HOWARD W	President & CEO	05/21/2019	240,331
ROBIN HOWARD W	President & CEO	05/23/2019	240,331
ROBIN HOWARD W	President & CEO	05/21/2019	1,097,656
ROBIN HOWARD W	President & CEO	05/23/2019	1,089,656
ROBIN HOWARD W	President & CEO	05/22/2019	1,112,689
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/16/2019	60,481
ROBIN HOWARD W	President & CEO	05/16/2019	419,825
Nicholson John	SVP & Chief Operating Officer	05/16/2019	127,895
Labrucherie Gil M	SVP & Chief Financial Officer	05/16/2019	118,171
Hora Maninder	SVP Pharma Dev & Mfg Ops	05/16/2019	76,825
Doberstein Stephen K	SVP & Chief Scientific Officer	05/16/2019	108,572
GREER R SCOTT	Director	03/08/2019	51,400
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/19/2019	76,641
ROBIN HOWARD W	President & CEO	02/20/2019	240,338
ROBIN HOWARD W	President & CEO	02/19/2019	240,331
ROBIN HOWARD W	President & CEO	02/21/2019	240,331
ROBIN HOWARD W	President & CEO	02/20/2019	1,440,029
ROBIN HOWARD W	President & CEO	02/19/2019	1,787,161
ROBIN HOWARD W	President & CEO	02/21/2019	1,366,986
Nicholson John	SVP & Chief Operating Officer	02/19/2019	162,015
Labrucherie Gil M	SVP & Chief Financial Officer	02/19/2019	152,265
Hora Maninder	SVP Pharma Dev & Mfg Ops	02/19/2019	101,143
Doberstein Stephen K	SVP & Chief Scientific Officer	02/19/2019	140,311
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/04/2019	172,312
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/04/2019	679,577
Nicholson John	SVP & Chief Operating Officer	01/28/2019	673,470
Nicholson John	SVP & Chief Operating Officer	01/28/2019	2,697,660
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/16/2018	153,612
ROBIN HOWARD W	President & CEO	11/16/2018	586,220
Nicholson John	SVP & Chief Operating Officer	11/16/2018	228,812
Labrucherie Gil M	SVP & Chief Financial Officer	11/16/2018	249,199
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/16/2018	179,546
Doberstein Stephen K	SVP & Chief Scientific Officer	11/16/2018	173,043
Lingnau Lutz	Director	09/20/2018	512,820
CHESS ROBERT	Director	09/19/2018	255,645
Ajer Jeffrey Robert	Director	09/20/2018	383,130
GREER R SCOTT	Director	09/04/2018	51,400
GREER R SCOTT	Director	09/04/2018	673,900
WINGER DENNIS L	Director	08/17/2018	213,900
WINGER DENNIS L	Director	08/21/2018	213,900
WINGER DENNIS L	Director	08/21/2018	904,500
WINGER DENNIS L	Director	08/17/2018	894,300
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2018	285,167
Nicholson John	SVP & Chief Operating Officer	08/16/2018	475,201
Labrucherie Gil M	SVP & Chief Financial Officer	08/16/2018	479,289
Hora Maninder	SVP Pharma Dev & Mfg Ops	08/16/2018	347,246
ROBIN HOWARD W	President & CEO	08/14/2018	427,600
ROBIN HOWARD W	President & CEO	08/16/2018	1,190,718
ROBIN HOWARD W	President & CEO	08/14/2018	2,403,200
Doberstein Stephen K	SVP & Chief Scientific Officer	08/16/2018	391,338
WINGER DENNIS L	Director	08/14/2018	1,030,069
WINGER DENNIS L	Director	08/13/2018	1,045,310
ROBIN HOWARD W	President & CEO	06/26/2018	463,230
ROBIN HOWARD W	President & CEO	06/25/2018	463,240
ROBIN HOWARD W	President & CEO	06/27/2018	463,230
ROBIN HOWARD W	President & CEO	06/26/2018	2,138,917
ROBIN HOWARD W	President & CEO	06/25/2018	2,245,568
ROBIN HOWARD W	President & CEO	06/27/2018	2,053,551
WHITFIELD ROY A	Director	06/06/2018	201,860
WHITFIELD ROY A	Director	06/05/2018	88,352
CHESS ROBERT	Director	06/05/2018	142,600
CHESS ROBERT	Director	06/05/2018	551,600
GREER R SCOTT	Director	06/06/2018	44,204
GREER R SCOTT	Director	06/04/2018	7,196
GREER R SCOTT	Director	06/06/2018	516,000
GREER R SCOTT	Director	06/04/2018	86,786
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/16/2018	298,203
ROBIN HOWARD W	President & CEO	05/16/2018	1,066,641
Nicholson John	SVP & Chief Operating Officer	05/16/2018	410,029
Labrucherie Gil M	SVP & Chief Financial Officer	05/16/2018	412,030
Hora Maninder	SVP Pharma Dev & Mfg Ops	05/16/2018	338,563
Doberstein Stephen K	SVP & Chief Scientific Officer	05/16/2018	286,445
CHESS ROBERT	Director	05/03/2018	219,700
CHESS ROBERT	Director	05/03/2018	2,070,050
Labrucherie Gil M	SVP & Chief Financial Officer	05/03/2018	320,700
Labrucherie Gil M	SVP & Chief Financial Officer	05/02/2018	320,700
Labrucherie Gil M	SVP & Chief Financial Officer	05/01/2018	320,700
Labrucherie Gil M	SVP & Chief Financial Officer	05/03/2018	2,485,800
Labrucherie Gil M	SVP & Chief Financial Officer	05/02/2018	2,568,900
Labrucherie Gil M	SVP & Chief Financial Officer	05/01/2018	2,509,500
ROBIN HOWARD W	President & CEO	05/03/2018	463,230
ROBIN HOWARD W	President & CEO	05/02/2018	463,230
ROBIN HOWARD W	President & CEO	05/01/2018	463,240
ROBIN HOWARD W	President & CEO	05/03/2018	3,590,572
ROBIN HOWARD W	President & CEO	05/02/2018	3,710,605
ROBIN HOWARD W	President & CEO	05/01/2018	3,624,889
WHITFIELD ROY A	Director	04/17/2018	427,800
Thomsen Jillian B.	SVP & Chief Accounting Officer	04/16/2018	148,388
Thomsen Jillian B.	SVP & Chief Accounting Officer	04/16/2018	1,408,366
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/10/2018	3,619
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/10/2018	53,046
Lingnau Lutz	Director	04/05/2018	277,200
Lingnau Lutz	Director	04/05/2018	3,052,200
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/09/2018	68,481
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/05/2018	144,200
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/09/2018	997,765
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/05/2018	2,035,000
GREER R SCOTT	Director	04/06/2018	427,800
GREER R SCOTT	Director	04/06/2018	2,766,600
Doberstein Stephen K	SVP & Chief Scientific Officer	04/09/2018	356,895
Doberstein Stephen K	SVP & Chief Scientific Officer	04/06/2018	1,005,505
Doberstein Stephen K	SVP & Chief Scientific Officer	04/09/2018	4,758,435
Doberstein Stephen K	SVP & Chief Scientific Officer	04/06/2018	10,131,745
CHESS ROBERT	Director	04/06/2018	219,700
CHESS ROBERT	Director	04/06/2018	2,303,600
KUEBLER CHRISTOPHER A	Director	03/07/2018	233,236
KUEBLER CHRISTOPHER A	Director	03/06/2018	13,364
KUEBLER CHRISTOPHER A	Director	03/06/2018	260,780
KUEBLER CHRISTOPHER A	Director	03/07/2018	3,643,134
Nicholson John	SVP & Chief Operating Officer	03/07/2018	10,059,464
Nicholson John	SVP & Chief Operating Officer	03/06/2018	11,794,800
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/16/2018	211,082
ROBIN HOWARD W	President & CEO	02/16/2018	1,060,637
Nicholson John	SVP & Chief Operating Officer	02/16/2018	404,664
Labrucherie Gil M	SVP & Chief Financial Officer	02/16/2018	288,382
Hora Maninder	SVP Pharma Dev & Mfg Ops	02/16/2018	238,453
Doberstein Stephen K	SVP & Chief Scientific Officer	02/16/2018	201,212
Nicholson John	SVP & Chief Operating Officer	01/31/2018	1,360,800
ROBIN HOWARD W	President & CEO	01/22/2018	944,996
ROBIN HOWARD W	President & CEO	01/22/2018	6,318,308
WINGER DENNIS L	Director	01/04/2018	403,988
KUEBLER CHRISTOPHER A	Director	01/02/2018	427,800
KUEBLER CHRISTOPHER A	Director	01/02/2018	1,759,800
ROBIN HOWARD W	President & CEO	12/13/2017	944,996
ROBIN HOWARD W	President & CEO	12/13/2017	4,640,815
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/16/2017	233,932
ROBIN HOWARD W	President & CEO	11/16/2017	799,192
Nicholson John	SVP & Chief Operating Officer	11/16/2017	292,803
Labrucherie Gil M	SVP & Chief Financial Officer	11/16/2017	296,253
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/16/2017	247,555
Gergel Ivan P.	SVP & Chief Medical Officer	11/16/2017	222,123
Doberstein Stephen K	SVP & Chief Scientific Officer	11/16/2017	211,508
Nicholson John	SVP & Chief Operating Officer	11/13/2017	231,000
Nicholson John	SVP & Chief Operating Officer	11/13/2017	601,080
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/07/2017	626,260
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/06/2017	54,701
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/06/2017	128,283
Doberstein Stephen K	SVP & Chief Scientific Officer	11/06/2017	199,310
Doberstein Stephen K	SVP & Chief Scientific Officer	11/08/2017	2,859,000
Doberstein Stephen K	SVP & Chief Scientific Officer	11/07/2017	718,648
Doberstein Stephen K	SVP & Chief Scientific Officer	11/06/2017	522,432
Doberstein Stephen K	SVP & Chief Scientific Officer	11/08/2017	9,027,000
Doberstein Stephen K	SVP & Chief Scientific Officer	11/07/2017	1,944,044
ROBIN HOWARD W	President & CEO	11/01/2017	945,008
ROBIN HOWARD W	President & CEO	11/01/2017	1,964,182
ROBIN HOWARD W	President & CEO	10/09/2017	944,996
ROBIN HOWARD W	President & CEO	10/09/2017	2,016,659
Hora Maninder	SVP Pharma Dev & Mfg Ops	10/05/2017	81,062
Hora Maninder	SVP Pharma Dev & Mfg Ops	10/05/2017	189,575
Doberstein Stephen K	SVP & Chief Scientific Officer	10/05/2017	416,242
Doberstein Stephen K	SVP & Chief Scientific Officer	10/05/2017	1,090,615
Labrucherie Gil M	SVP & Chief Financial Officer	10/02/2017	1,360,800
Labrucherie Gil M	SVP & Chief Financial Officer	10/02/2017	2,934,000
Gergel Ivan P.	SVP & Chief Medical Officer	10/02/2017	626,012
Gergel Ivan P.	SVP & Chief Medical Officer	09/29/2017	477,988
Gergel Ivan P.	SVP & Chief Medical Officer	10/02/2017	1,372,804
Gergel Ivan P.	SVP & Chief Medical Officer	09/29/2017	1,040,836
Lingnau Lutz	Director	09/22/2017	109,850
KUEBLER CHRISTOPHER A	Director	09/22/2017	87,440
CHESS ROBERT	Director	09/21/2017	139,008
ROBIN HOWARD W	President & CEO	09/06/2017	944,996
ROBIN HOWARD W	President & CEO	09/06/2017	1,794,993
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2017	51,159
ROBIN HOWARD W	President & CEO	08/16/2017	945,008
ROBIN HOWARD W	President & CEO	08/16/2017	1,766,081
Nicholson John	SVP & Chief Operating Officer	08/16/2017	61,380
Labrucherie Gil M	SVP & Chief Financial Officer	08/16/2017	61,380
Hora Maninder	SVP Pharma Dev & Mfg Ops	08/16/2017	57,110
Gergel Ivan P.	SVP & Chief Medical Officer	08/16/2017	38,582
Doberstein Stephen K	SVP & Chief Scientific Officer	08/16/2017	32,863
WHITFIELD ROY A	Director	08/10/2017	628,250
Gergel Ivan P.	SVP & Chief Medical Officer	07/18/2017	606,317
Gergel Ivan P.	SVP & Chief Medical Officer	07/18/2017	1,158,812
Lingnau Lutz	Director	07/14/2017	427,800
Lingnau Lutz	Director	07/14/2017	622,800
Gergel Ivan P.	SVP & Chief Medical Officer	07/11/2017	92,615
Gergel Ivan P.	SVP & Chief Medical Officer	07/12/2017	405,069
Gergel Ivan P.	SVP & Chief Medical Officer	07/11/2017	176,505
Gergel Ivan P.	SVP & Chief Medical Officer	07/12/2017	773,813
Krivulka Joseph J	Director	06/26/2017	125,550
Nicholson John	SVP & Chief Operating Officer	06/07/2017	951,000
Nicholson John	SVP & Chief Operating Officer	06/07/2017	1,956,708
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/16/2017	51,827
ROBIN HOWARD W	President & CEO	05/16/2017	163,985
Nicholson John	SVP & Chief Operating Officer	05/16/2017	61,504
Labrucherie Gil M	SVP & Chief Financial Officer	05/16/2017	62,149
Hora Maninder	SVP Pharma Dev & Mfg Ops	05/16/2017	57,848
Gergel Ivan P.	SVP & Chief Medical Officer	05/16/2017	28,347
Doberstein Stephen K	SVP & Chief Scientific Officer	05/16/2017	33,255
CHESS ROBERT	Director	05/15/2017	41,850
CHESS ROBERT	Director	05/15/2017	98,950
CHESS ROBERT	Director	04/17/2017	41,850
CHESS ROBERT	Director	04/17/2017	93,600
Lingnau Lutz	Director	04/07/2017	140,350
Doberstein Stephen K	SVP & Chief Scientific Officer	04/05/2017	953,000
Doberstein Stephen K	SVP & Chief Scientific Officer	04/05/2017	2,170,000
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/05/2017	2,466,000
Hora Maninder	SVP Pharma Dev & Mfg Ops	04/05/2017	3,906,000
KUEBLER CHRISTOPHER A	Director	04/05/2017	125,550
KUEBLER CHRISTOPHER A	Director	04/05/2017	328,200
Thomsen Jillian B.	SVP & Chief Accounting Officer	03/20/2017	1,120,875
Thomsen Jillian B.	SVP & Chief Accounting Officer	03/20/2017	2,215,125
WHITFIELD ROY A	Director	03/15/2017	117,180
CHESS ROBERT	Director	03/14/2017	41,850
CHESS ROBERT	Director	03/14/2017	77,050
Labrucherie Gil M	SVP & Chief Financial Officer	03/03/2017	278,512
Labrucherie Gil M	SVP & Chief Financial Officer	03/02/2017	1,061,988
Labrucherie Gil M	SVP & Chief Financial Officer	03/03/2017	494,234
Labrucherie Gil M	SVP & Chief Financial Officer	03/02/2017	2,537,716
Lingnau Lutz	Director	02/21/2017	154,200
Lingnau Lutz	Director	02/21/2017	392,400
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/16/2017	25,820
ROBIN HOWARD W	President & CEO	02/16/2017	113,477
Nicholson John	SVP & Chief Operating Officer	02/16/2017	42,534
Labrucherie Gil M	SVP & Chief Financial Officer	02/16/2017	30,997
Hora Maninder	SVP Pharma Dev & Mfg Ops	02/16/2017	28,842
Gergel Ivan P.	SVP & Chief Medical Officer	02/16/2017	19,145
Doberstein Stephen K	SVP & Chief Scientific Officer	02/16/2017	16,570
Nicholson John	SVP & Chief Operating Officer	02/10/2017	209,250
ROBIN HOWARD W	President & CEO	02/08/2017	406,875
ROBIN HOWARD W	President & CEO	02/08/2017	1,141,000
Nicholson John	SVP & Chief Operating Officer	02/02/2017	309,202
Nicholson John	SVP & Chief Operating Officer	02/03/2017	39,548
Nicholson John	SVP & Chief Operating Officer	02/02/2017	823,208
Nicholson John	SVP & Chief Operating Officer	02/03/2017	106,142
ROBIN HOWARD W	President & CEO	01/17/2017	406,875
ROBIN HOWARD W	President & CEO	01/17/2017	1,080,625
ROBIN HOWARD W	President & CEO	12/07/2016	406,875
ROBIN HOWARD W	President & CEO	12/07/2016	1,071,000
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/16/2016	27,725
ROBIN HOWARD W	President & CEO	11/17/2016	406,875
ROBIN HOWARD W	President & CEO	11/17/2016	1,213,625
ROBIN HOWARD W	President & CEO	11/16/2016	83,174
Nicholson John	SVP & Chief Operating Officer	11/16/2016	23,090
Labrucherie Gil M	SVP & Chief Financial Officer	11/16/2016	23,090
Hora Maninder	SVP Pharma Dev & Mfg Ops	11/16/2016	23,090
Gergel Ivan P.	SVP & Chief Medical Officer	11/16/2016	11,838
Doberstein Stephen K	SVP & Chief Scientific Officer	11/16/2016	9,353
GREER R SCOTT	Director	10/24/2016	202,500
ROBIN HOWARD W	President & CEO	10/04/2016	406,875
ROBIN HOWARD W	President & CEO	10/04/2016	1,492,750
WHITFIELD ROY A	Director	09/23/2016	239,820
Lingnau Lutz	Director	09/15/2016	171,540
KUEBLER CHRISTOPHER A	Director	09/16/2016	143,475
CHESS ROBERT	Director	09/15/2016	230,520
ROBIN HOWARD W	President & CEO	09/01/2016	406,875
ROBIN HOWARD W	President & CEO	09/01/2016	1,560,125
Nicholson John	SVP & Chief Operating Officer	08/16/2016	58,247
Thomsen Jillian B.	SVP & Chief Accounting Officer	08/16/2016	69,731
ROBIN HOWARD W	President & CEO	08/16/2016	207,507
Labrucherie Gil M	SVP & Chief Financial Officer	08/16/2016	58,036
Hora Maninder	SVP Pharma Dev & Mfg Ops	08/16/2016	58,036
Gergel Ivan P.	SVP & Chief Medical Officer	08/16/2016	29,589
Doberstein Stephen K	SVP & Chief Scientific Officer	08/16/2016	23,460
CHESS ROBERT	Director	08/01/2016	25,750
CHESS ROBERT	Director	08/01/2016	86,300
Thomsen Jillian B.	SVP & Chief Accounting Officer	07/11/2016	465,000
Thomsen Jillian B.	SVP & Chief Accounting Officer	07/11/2016	1,509,000
CHESS ROBERT	Director	07/01/2016	25,750
CHESS ROBERT	Director	07/01/2016	70,500
CHESS ROBERT	Director	06/01/2016	25,750
CHESS ROBERT	Director	06/01/2016	77,500
Nicholson John	SVP & Chief Financial Officer	05/16/2016	0
Nicholson John	SVP & Chief Financial Officer	05/17/2016	11,624
ROBIN HOWARD W	President & CEO	05/16/2016	1
ROBIN HOWARD W	President & CEO	05/17/2016	29,469
Doberstein Stephen K	SVP & Chief Scientific Officer	05/16/2016	0
Doberstein Stephen K	SVP & Chief Scientific Officer	05/17/2016	4,604
Gergel Ivan P.	SVP & Chief Medical Officer	05/16/2016	0
Gergel Ivan P.	SVP & Chief Medical Officer	05/17/2016	5,867
Hora Maninder	SVP Pharma Dev & Mfg Ops	05/16/2016	0
Hora Maninder	SVP Pharma Dev & Mfg Ops	05/17/2016	11,339
Labrucherie Gil M	SVP & General Counsel	05/16/2016	0
Labrucherie Gil M	SVP & General Counsel	05/17/2016	11,353
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/16/2016	0
Thomsen Jillian B.	SVP & Chief Accounting Officer	05/17/2016	9,832
Lingnau Lutz	Director	04/25/2016	125,550
Lingnau Lutz	Director	04/25/2016	244,050
Thomsen Jillian B.	SVP & Chief Accounting Officer	03/09/2016	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	03/09/2016	176,850
Gergel Ivan P.	SVP & Chief Medical Officer	02/16/2016	0
Gergel Ivan P.	SVP & Chief Medical Officer	02/17/2016	6,628
Nicholson John	SVP & Chief Financial Officer	02/16/2016	0
Nicholson John	SVP & Chief Financial Officer	02/17/2016	11,479
ROBIN HOWARD W	President & CEO	02/16/2016	1
ROBIN HOWARD W	President & CEO	02/17/2016	25,592
Doberstein Stephen K	SVP & Chief Scientific Officer	02/16/2016	0
Doberstein Stephen K	SVP & Chief Scientific Officer	02/17/2016	4,649
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/16/2016	0
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/17/2016	8,535
Labrucherie Gil M	SVP & General Counsel	02/16/2016	0
Labrucherie Gil M	SVP & General Counsel	02/17/2016	9,858
Hora Maninder	SVP Pharma Dev & Mfg Ops	02/16/2016	0
Hora Maninder	SVP Pharma Dev & Mfg Ops	02/17/2016	11,479
Labrucherie Gil M	SVP & General Counsel	02/10/2016	75,362
Labrucherie Gil M	SVP & General Counsel	02/10/2016	134,042
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/10/2016	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	02/10/2016	172,350
ROBIN HOWARD W	President & CEO	02/10/2016	430,662
ROBIN HOWARD W	President & CEO	02/10/2016	765,992
Thomsen Jillian B.	SVP & Chief Accounting Officer	01/19/2016	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	01/19/2016	211,800
ROBIN HOWARD W	President & CEO	01/19/2016	430,669
ROBIN HOWARD W	President & CEO	01/19/2016	941,338
Lingnau Lutz	Director	01/20/2016	77,250
Lingnau Lutz	Director	01/20/2016	217,650
Labrucherie Gil M	SVP & General Counsel	01/19/2016	75,369
Labrucherie Gil M	SVP & General Counsel	01/19/2016	164,738
Labrucherie Gil M	SVP & General Counsel	12/03/2015	308,040
Labrucherie Gil M	SVP & General Counsel	12/03/2015	714,166
ROBIN HOWARD W	President & CEO	12/03/2015	837,840
ROBIN HOWARD W	President & CEO	12/03/2015	1,983,766
KUEBLER CHRISTOPHER A	Director	12/04/2015	77,250
KUEBLER CHRISTOPHER A	Director	12/04/2015	237,300
Thomsen Jillian B.	SVP & Chief Accounting Officer	12/03/2015	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	12/03/2015	238,050
WANG SUSAN	Director	11/18/2015	153,162
WANG SUSAN	Director	11/20/2015	418,430
WANG SUSAN	Director	11/19/2015	77,758
WANG SUSAN	Director	11/18/2015	305,580
WANG SUSAN	Director	11/20/2015	743,490
WANG SUSAN	Director	11/19/2015	227,223
ROBIN HOWARD W	President & CEO	11/11/2015	837,833
ROBIN HOWARD W	President & CEO	11/11/2015	1,690,000
Labrucherie Gil M	SVP & General Counsel	11/11/2015	308,033
Labrucherie Gil M	SVP & General Counsel	11/11/2015	608,400
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/11/2015	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	11/11/2015	202,800
Lingnau Lutz	Director	10/28/2015	83,125
Lingnau Lutz	Director	10/28/2015	150,000
GREER R SCOTT	Director	10/15/2015	368,550
ROBIN HOWARD W	President & CEO	10/06/2015	837,833
ROBIN HOWARD W	President & CEO	10/06/2015	1,373,750
Labrucherie Gil M	SVP & General Counsel	10/06/2015	308,033
Labrucherie Gil M	SVP & General Counsel	10/06/2015	494,550
Thomsen Jillian B.	SVP & Chief Accounting Officer	10/06/2015	99,750
Thomsen Jillian B.	SVP & Chief Accounting Officer	10/06/2015	164,850
Thomsen Jillian B.	SVP & Chief Accounting Officer	09/23/2015	66,500
Thomsen Jillian B.	SVP & Chief Accounting Officer	09/23/2015	130,400
ROBIN HOWARD W	President & CEO	09/23/2015	837,827
ROBIN HOWARD W	President & CEO	09/23/2015	1,629,987
Labrucherie Gil M	SVP & General Counsel	09/23/2015	308,027
Labrucherie Gil M	SVP & General Counsel	09/23/2015	586,787
WHITFIELD ROY A	Director	09/11/2015	132,150
Labrucherie Gil M	SVP & General Counsel	08/13/2015	232,664
Labrucherie Gil M	SVP & General Counsel	08/13/2015	362,996
ROBIN HOWARD W	President & CEO	08/13/2015	407,164
ROBIN HOWARD W	President & CEO	08/13/2015	635,246
Nicholson John	SVP & Chief Financial Officer	08/12/2015	584,000
Nicholson John	SVP & Chief Financial Officer	08/11/2015	2,437,100
Nicholson John	SVP & Chief Financial Officer	08/11/2015	2,716,089
Nicholson John	SVP & Chief Financial Officer	08/12/2015	733,325
Krivulka Joseph J	Director	07/24/2015	132,150
ROBIN HOWARD W	President & CEO	07/14/2015	407,171
ROBIN HOWARD W	President & CEO	07/14/2015	687,175
Labrucherie Gil M	SVP & General Counsel	07/14/2015	232,671
Labrucherie Gil M	SVP & General Counsel	07/14/2015	392,675
WANG SUSAN	Director	06/29/2015	209,400
WANG SUSAN	Director	06/29/2015	381,000
CHESS ROBERT	Director	06/19/2015	132,150
CHESS ROBERT	Director	06/19/2015	177,150
Lingnau Lutz	Director	06/15/2015	166,250
Lingnau Lutz	Director	06/15/2015	278,750
KUEBLER CHRISTOPHER A	Director	01/13/2015	132,150
KUEBLER CHRISTOPHER A	Director	01/13/2015	240,000
CHESS ROBERT	Director	12/29/2014	449,580
CHESS ROBERT	Director	12/29/2014	452,530
Thomsen Jillian B.	SVP & Chief Accounting Officer	12/22/2014	56,900
Thomsen Jillian B.	SVP & Chief Accounting Officer	12/22/2014	77,800
Labrucherie Gil M	SVP & General Counsel	12/01/2014	139,500
Labrucherie Gil M	SVP & General Counsel	11/28/2014	418,500
Labrucherie Gil M	SVP & General Counsel	12/01/2014	510,000
Labrucherie Gil M	SVP & General Counsel	11/28/2014	1,531,800
ROBIN HOWARD W	President & CEO	12/01/2014	1,459,211
ROBIN HOWARD W	President & CEO	11/28/2014	983,789
ROBIN HOWARD W	President & CEO	11/28/2014	2,398,867
ROBIN HOWARD W	President & CEO	12/01/2014	3,553,952
Labrucherie Gil M	SVP & General Counsel	11/24/2014	136,710
Labrucherie Gil M	SVP & General Counsel	11/24/2014	157,920
ROBIN HOWARD W	President & CEO	11/25/2014	6,783,744
ROBIN HOWARD W	President & CEO	11/24/2014	1,928,256
ROBIN HOWARD W	President & CEO	11/24/2014	1,994,656
ROBIN HOWARD W	President & CEO	11/25/2014	7,152,832
Lingnau Lutz	Director	11/24/2014	132,150
Lingnau Lutz	Director	11/24/2014	225,300
Labrucherie Gil M	SVP & General Counsel	11/03/2014	112,662
Labrucherie Gil M	SVP & General Counsel	11/03/2014	136,422
KUEBLER CHRISTOPHER A	Director	08/05/2013	142,625
KUEBLER CHRISTOPHER A	Director	08/05/2013	155,125
WHITFIELD ROY A	Director	08/05/2013	142,625
WHITFIELD ROY A	Director	08/05/2013	155,125
KUEBLER CHRISTOPHER A	Director	09/27/2012	108,250
KUEBLER CHRISTOPHER A	Director	09/27/2012	133,250
WINGER DENNIS L	Director	09/14/2012	45,908
CHESS ROBERT	Director	07/13/2012	146,886
CHESS ROBERT	Director	07/13/2012	204,009
CHESS ROBERT	Director	03/08/2011	40,500

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FUNDS WITH A POSITION IN NEKTAR THERAPEUTICS

Fund	# Shares Owned	% of Portfolio	% Change	Investing Style
BLACKROCK INC.	6,104,217	0.00009%	-20.57%	Other
RENAISSANCE TECHNOLOGIES LLC	5,325,475	0.00466%	51.87%	Other
D. E. SHAW & CO., INC.	4,098,844	0.00202%	-33.06%	Other
GEODE CAPITAL MANAGEMENT, LLC	2,039,614	0.00012%	4.31%	Other
AQR CAPITAL MANAGEMENT LLC	1,435,549	0.00153%	-60.84%	Other
UBS OCONNOR LLC	1,250,742	0.05%	-9.12%	Value
BALYASNY ASSET MANAGEMENT L.P.	1,100,000	0.00117%	-17.52%	Event Driven
TUDOR INVESTMENT CORP ET AL	57,083	0.00026%	No change	Event Driven, Other

CHANGE IN SHARES OUTSTANDING FOR NEKTAR THERAPEUTICS

STOCK BUYBACKS FOR NEKTAR THERAPEUTICS

Period of Report

Previous Period

% Change in Shares

10-K/10-Q Filings

Quarter

12/31/2023

09/30/2023

0.34%

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